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Gpr83 Gene Detail
Summary
  • Symbol
    Gpr83
  • Name
    G protein-coupled receptor 83
  • Synonyms
    Gir, GIR, glucocorticoid-induced receptor, Gpr72, RP105, RP39, RP82
  • Feature Type
    protein coding gene
  • IDs
    MGI:95712
    NCBI Gene: 14608
  • Gene Overview
    MyGene.info: GPR83
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:14860210-14870789 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10580 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 4.40 cM, cytoband A2-A3
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    GPR83, G protein-coupled receptor 83
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GPR83, G protein-coupled receptor 83
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GIR, GPR72
  • Links
    NCBI Gene ID: 10888
    neXtProt AC: NX_Q9NYM4
    UniProt: Q9NYM4

  • Chr Location
    11q21; chr11:94377311-94401479 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal regulatory T cell development. Mice homozygous for a different targeted allele exhibit attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027389 VEGA Gene Model | MGI Sequence Detail 10580 C57BL/6J ±  kb
    transcript OTTMUST00000067740 VEGA | MGI Sequence Detail 3586 Not Applicable  
    polypeptide OTTMUSP00000034127 VEGA | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      74 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10078, MGI:2143277
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:1663 Harrigan MT, et al., Identification of a gene induced by glucocorticoids in murine T-cells: a potential G protein-coupled receptor. Mol Endocrinol. 1991 Sep;5(9):1331-8
    • Latest
      J:259508 Gomes I, et al., Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory