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Ghrhr
Gene Detail
 Symbol
Name
ID
Ghrhr
growth hormone releasing hormone receptor
MGI:95710
Synonyms Ghrfr
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr6:55376295-55388530 bp, + strand
From NCBI annotation of GRCm38

  12236 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Ghrhr

Human
homologs
Human Homolog GHRHR, growth hormone releasing hormone receptor
NCBI Gene ID 2692
neXtProt AC  NX_Q02643
Human Synonyms  GHRFR, GRFR, IGHD1B
Human Chr (Location)  7p14; chr7:30964021-30979531 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GHRHR
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Spontaneous(1)
 
Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process activation of adenylate cyclase activity, adenohypophysis development, ...
Component cell, cell surface, ...
Function G-protein coupled receptor activity, growth factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (1)    Images (2)
Theiler Stages: 25
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(3) cDNA(8) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000004654 (Evidence)
Entrez Gene14602 (Evidence)
UniGene89928
DFCITC1598973
DoTSDT.87036730, DT.87055103, DT.94223228
NIA Mouse Gene IndexU006905
Consensus CDS ProjectCCDS20165.1
International Mouse Knockout Project StatusGhrhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14602 NCBI Gene Model | MGI Sequence Detail 12236 C57BL/6J ±  kb
transcript NM_001003685 RefSeq | MGI Sequence Detail 1598 C57BL/6 
polypeptide P32082 UniProt | EBI | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003288 GPCR, family 2, growth hormone-releasing hormone receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007972 growth hormone-releasing hormone receptor
Graphical View of Protein Domain Structure
References (Earliest) J:64445 Eicher EM, lit - little. Mouse News Lett. 1972;47:36
(Latest) J:188071 Cheng X, et al., Hormonal and chemical regulation of paraoxonases in mice. J Pharmacol Exp Ther. 2012 Sep;342(3):688-95
All references(110)
Other
accession IDs
MGD-MRK-10072, MGD-MRK-10074, MGD-MRK-11813

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory