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Ghrhr Gene Detail
Summary
  • Symbol
    Ghrhr
  • Name
    growth hormone releasing hormone receptor
  • Synonyms
    Ghrfr
  • Feature Type
    protein coding gene
  • IDs
    MGI:95710
    NCBI Gene: 14602
Location & Maps
more
  • Sequence Map
    Chr6:55376295-55388530 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12236 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GHRHR, growth hormone releasing hormone receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GHRHR, growth hormone releasing hormone receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GHRFR, GRFR, IGHD1B
  • Links
    NCBI Gene ID: 2692
    neXtProt AC: NX_Q02643

  • Chr Location
    7p14; chr7:30964021-30979531 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GHRHR associations

Human Disease Mouse Models
       Isolated Growth Hormone Deficiency, Type IB; IGHD1B   OMIM: 612781
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 1 allele in 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Endonuclease-mediated
    1
  • Spontaneous
    1
  • Targeted
    4
  • Incidental Mutations
Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14602 NCBI Gene Model | MGI Sequence Detail 12236 C57BL/6J ±  kb
transcript NM_001003685 RefSeq | MGI Sequence Detail 1598 C57BL/6  
polypeptide P32082 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007972 growth hormone-releasing hormone receptor
  • InterPro Domains
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR003288 GPCR, family 2, growth hormone-releasing hormone receptor
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
Molecular
Reagents
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  • All nucleic 17
    Genomic 3
    cDNA 9
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10072, MGD-MRK-10074, MGD-MRK-11813
References
more
  • Summaries
    All 110
    Developmental Gene Expression 6
    Gene Ontology 29
    Phenotypes 64
  • Earliest
    J:64445 Eicher EM, lit - little. Mouse News Lett. 1972;47:36
  • Latest
    J:220657 Edderkaoui B, et al., ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size. Physiol Genomics. 2013 Dec 15;45(24):1222-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory