Ghrhr
Gene Detail

Symbol Name ID

Ghrhr growth hormone releasing hormone receptor MGI:95710

Synonyms

Ghrfr

Feature Type

protein coding gene

Genetic Map

Chromosome 6

27.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr6:55376295-55388530 bp, + strand From NCBI annotation of GRCm38   12236 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Ghrhr

Human homologs

Human Homolog		GHRHR, growth hormone releasing hormone receptor
NCBI Gene ID		2692
neXtProt AC		NX_Q02643
Human Synonyms		GHRFR, GRFR, IGHD1B
Human Chr (Location)		7p14; chr7:31003636-31019146 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GHRHR

Alleles and phenotypes

All alleles(5) : Targeted(4) Spontaneous(1)
 

Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (65 annotations)

Process	activation of adenylate cyclase activity, adenohypophysis development, ...
Component	cell surface, cytoplasm, ...
Function	G-protein coupled receptor activity, growth factor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (1)    Images (2)
Theiler Stages: 25

Assay Type	Results
RNA in situ	2
RT-PCR	2

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(3) cDNA(8) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000004654 (Evidence)
Entrez Gene	14602 (Evidence)
UniGene	89928
DFCI	TC1598973
DoTS	DT.87036730, DT.87055103, DT.94223228
NIA Mouse Gene Index	U006905
Consensus CDS Project	CCDS20165.1
International Mouse Knockout Project Status	Ghrhr

Sequences

Length	Strain/Species
genomic	14602	NCBI Gene Model | MGI Sequence Detail	12236	C57BL/6J
transcript	NM_001003685	RefSeq | MGI Sequence Detail	1598	C57BL/6
polypeptide	P32082	UniProt | EBI | MGI Sequence Detail	423	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR003288	GPCR, family 2, growth hormone-releasing hormone receptor
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000007972	growth hormone-releasing hormone receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:64445 Eicher EM, lit - little. Mouse News Lett. 1972;47:36
(Latest) J:188071 Cheng X, et al., Hormonal and chemical regulation of paraoxonases in mice. J Pharmacol Exp Ther. 2012 Sep;342(3):688-95
All references(110)

Other accession IDs

MGD-MRK-10072, MGD-MRK-10074, MGD-MRK-11813