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Ghrhr Gene Detail
Summary
  • Symbol
    Ghrhr
  • Name
    growth hormone releasing hormone receptor
  • Synonyms
    Ghrfr
  • Feature Type
    protein coding gene
  • IDs
    MGI:95710
    NCBI Gene: 14602
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:55376295-55388530 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12236 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.38 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    GHRHR, growth hormone releasing hormone receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GHRHR, growth hormone releasing hormone receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GHRFR, GRFR, IGHD1B
  • Links
    NCBI Gene ID: 2692
    neXtProt AC: NX_Q02643
    UniProt: Q02643

  • Chr Location
    7p14.3; chr7:30964021-30979531 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GHRHR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 2 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057887 VEGA Gene Model | MGI Sequence Detail 12236 C57BL/6J ±  kb
    transcript OTTMUST00000142147 VEGA | MGI Sequence Detail 1550 Not Applicable  
    polypeptide OTTMUSP00000074204 VEGA | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      87 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007972 growth hormone-releasing hormone receptor
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003288 GPCR, family 2, growth hormone-releasing hormone receptor
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
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    • All nucleic 18
      Genomic 3
      cDNA 10
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10072, MGD-MRK-10074, MGD-MRK-11813
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 9
      Gene Ontology 30
      Phenotypes 69
    • Earliest
      J:5647 Eicher EM, et al., Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered. 1976 Mar-Apr;67(2):87-91
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/02/2018
    MGI 6.12
    The Jackson Laboratory