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Ghrhr Gene Detail
Summary
  • Symbol
    Ghrhr
  • Name
    growth hormone releasing hormone receptor
  • Synonyms
    Ghrfr
  • Feature Type
    protein coding gene
  • IDs
    MGI:95710
    NCBI Gene: 14602
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55376295-55388530 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.38 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95710
protein coding gene Chr6:55376295-55388530 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030773
protein coding gene Chr6:54777734-54794336 (+)
A/J MGP_AJ_G0030742
protein coding gene Chr6:52237147-52249168 (+)
AKR/J MGP_AKRJ_G0030669
protein coding gene Chr6:54013186-54025219 (+)
BALB/cJ MGP_BALBcJ_G0030754
protein coding gene Chr6:52609877-52621907 (+)
C3H/HeJ MGP_C3HHeJ_G0030467
protein coding gene Chr6:54036608-54050240 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031209
protein coding gene Chr6:56005059-56018778 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028415
protein coding gene Chr6:49846743-49859242 (+)
CAST/EiJ MGP_CASTEiJ_G0029870
protein coding gene Chr6:53890161-53907178 (+)
CBA/J MGP_CBAJ_G0030441
protein coding gene Chr6:58300295-58315838 (+)
DBA/2J MGP_DBA2J_G0030591
protein coding gene Chr6:52135998-52148049 (+)
FVB/NJ MGP_FVBNJ_G0030543
protein coding gene Chr6:51735932-51748277 (+)
LP/J MGP_LPJ_G0030676
protein coding gene Chr6:54712060-54725804 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030577
protein coding gene Chr6:60802848-60816429 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031239
protein coding gene Chr6:53983015-53996093 (+)
PWK/PhJ MGP_PWKPhJ_G0029583
protein coding gene Chr6:51802249-51815285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029417
protein coding gene Chr6:53366458-53381651 (+)
WSB/EiJ MGP_WSBEiJ_G0029947
protein coding gene Chr6:54012793-54024940 (+)



Homology
more
  • Human Ortholog
    GHRHR, growth hormone releasing hormone receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GHRHR, growth hormone releasing hormone receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GHRFR, GRFR, IGHD1B, IGHD4
  • Links
    NCBI Gene ID: 2692
    neXtProt AC: NX_Q02643
    UniProt: Q02643

  • Chr Location
    7p14.3; chr7:30964021-30979531 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 2 alleles in 4 genetic backgrounds
    19 phenotypes from multigenic genotypes
    2 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14602 NCBI Gene Model | MGI Sequence Detail 12236 C57BL/6J ±  kb
    transcript NM_001003685 RefSeq | MGI Sequence Detail 1598 C57BL/6  
    polypeptide P32082 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007972 growth hormone-releasing hormone receptor
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003288 GPCR, family 2, growth hormone-releasing hormone receptor
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 3
      cDNA 10
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10072, MGD-MRK-10074, MGD-MRK-11813
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 9
      Gene Ontology 30
      Phenotypes 69
    • Earliest
      J:5647 Eicher EM, et al., Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered. 1976 Mar-Apr;67(2):87-91
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory