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Ghrhr
Gene Detail
Symbol

Name
ID
Ghrhr
growth hormone releasing hormone receptor
MGI:95710
Synonyms
Ghrfr
Feature Type
protein coding gene
Genetic Map
Chromosome 6
27.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr6:55376295-55388530 bp, + strand
From NCBI annotation of GRCm38

  12236 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: GHRHR
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Ghrhr

Human
homologs
GHRHR, growth hormone releasing hormone receptor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2692
neXtProt AC: NX_Q02643

Human Synonyms: GHRFR, GRFR, IGHD1B

Human Chr (Location): 7p14; chr7:30964021-30979531 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GHRHR

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous null mutation exhibit reduced growth from 2 weeks of age, impaired growth hormone synthesis and release, obesity, decreased bone mass, reduced fertility in males, impaired first lactations, and extended life span.
 
Phenotype Images(2)
Interactions
Ghrhr interacts with 23 markers (Mir7b, Mir29b-2, Mir125b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process activation of adenylate cyclase activity, adenohypophysis development, ...
Component cell, cell surface, ...
Function G-protein coupled receptor activity, growth factor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (4)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 2
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ghrhra    NEW 
Molecular
reagents
All nucleic(15) Genomic(3) cDNA(8) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000004654 (Evidence)
Entrez Gene 14602 (Evidence)
UniGene 89928
DFCI TC1598973
DoTS DT.87036730, DT.87055103, DT.94223228
NIA Mouse Gene Index U006905
Consensus CDS Project CCDS20165.1
International Mouse Phenotyping Consortium Status Ghrhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14602 NCBI Gene Model | MGI Sequence Detail 12236 C57BL/6J ±  kb
transcript NM_001003685 RefSeq | MGI Sequence Detail 1598 C57BL/6 
polypeptide P32082 UniProt | EBI | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003288 GPCR, family 2, growth hormone-releasing hormone receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007972 growth hormone-releasing hormone receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:64445 Eicher EM, lit - little. Mouse News Lett. 1972;47:36
(Latest) J:220657 Edderkaoui B, et al., ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size. Physiol Genomics. 2013 Dec 15;45(24):1222-8
All references(114)
Other
accession IDs
MGD-MRK-10072, MGD-MRK-10074, MGD-MRK-11813

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory