Ggt1
Gene Detail

Symbol

Name
ID

Ggt1
gamma-glutamyltransferase 1
MGI:95706

Synonyms

CD224, dwg, GGT, Ggtp

Feature Type

protein coding gene

Genetic Map

Chromosome 10
38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:75561604-75586200 bp, + strand From VEGA annotation of GRCm38   24597 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:68450  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Ggt1

Human
homologs

Human Homolog		GGT1, gamma-glutamyltransferase 1
NCBI Gene ID		2678
neXtProt AC		NX_P19440
Human Synonyms		CD224, D22S672, D22S732, GGT, GGT 1, GTG
Human Chr (Location)		22q11.23; chr22:24583750-24629005 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(2) Spontaneous(2) Targeted(4)
Genomic Mutations involving Ggt1 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.

 
Human Diseases Modeled in Mice Using Ggt1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)

Interactions

Ggt1 interacts with 32 markers (Mir17, Mir20b, Mir22, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (30 annotations)

Process	cellular response to mechanical stimulus, cysteine biosynthetic process, ...
Component	extracellular space, extracellular vesicular exosome, ...
Function	gamma-glutamyltransferase activity, glutathione hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)

Data Summary: Results (158)    Tissues (134)    Images (15)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	10
RNA in situ	112
Northern blot	2
RT-PCR	34

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(26) Genomic(6) cDNA(18) Primer pair(2)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000034127 (Evidence)
Ensembl Gene Model	ENSMUSG00000006345 (Evidence)
Entrez Gene	14598 (Evidence)
DFCI	TC1575925, TC1743892
DoTS	DT.491842, DT.91329392, DT.94350914, DT.94360260, DT.94390181, DT.97387249
NIA Mouse Gene Index	U011662
EC	2.3.2.2, 3.4.19.13, 3.4.19.14
Consensus CDS Project	CCDS23927.1
International Mouse Knockout Project Status	Ggt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034127	VEGA Gene Model | MGI Sequence Detail	24597	C57BL/6J
transcript	OTTMUST00000086360	VEGA | MGI Sequence Detail	2140	Not Applicable
polypeptide	OTTMUSP00000046755	VEGA | MGI Sequence Detail	568	Not Applicable

All sequences(138) RefSeq(8) UniProt(29)

Polymorphisms

SNPs within 2kb(117 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000101	Gamma-glutamyltranspeptidase
Protein Ontology	PR:000001458	gamma-glutamyltranspeptidase 1

References

(Earliest) J:14610 Curto KA, et al., Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. J Histochem Cytochem. 1988 Feb;36(2):159-66
(Latest) J:202186 Yamada K, et al., Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary gamma-glutamyltransferase deficiency. Exp Anim. 2013;62(2):151-7
All references(73)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942