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Ggt1 Gene Detail
Summary
  • Symbol
    Ggt1
  • Name
    gamma-glutamyltransferase 1
  • Synonyms
    CD224, dwg, GGT, Ggtp
  • Feature Type
    protein coding gene
  • IDs
    MGI:95706
    NCBI Gene: 14598
  • Gene Overview
    MyGene.info: GGT1
Location & Maps
more
  • Sequence Map
    Chr10:75561604-75586200 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24597 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.55 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD224, D22S672, D22S732, GGT, GGT 1, GTG
  • Links
    NCBI Gene ID: 2678
    neXtProt AC: NX_P19440

  • Chr Location
    22q11.23; chr22:24583750-24629005 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68450
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: GGT1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ggt1 mouse models

Human Disease Mouse Models
       Glutathionuria   OMIM: 231950 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Spontaneous
    2
  • Targeted
    4
  • Genomic Mutations
    2 involving Ggt1
  • Incidental Mutations
Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034127 VEGA Gene Model | MGI Sequence Detail 24597 C57BL/6J ±  kb
transcript OTTMUST00000086360 VEGA | MGI Sequence Detail 2140 Not Applicable  
polypeptide OTTMUSP00000046755 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    116 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 6
    cDNA 18
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942
References
more
  • Summaries
    All 69
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:14610 Curto KA, et al., Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. J Histochem Cytochem. 1988 Feb;36(2):159-66
  • Latest
    J:202186 Yamada K, et al., Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary gamma-glutamyltransferase deficiency. Exp Anim. 2013;62(2):151-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory