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Ggt1
Gene Detail
Symbol

Name
ID
Ggt1
gamma-glutamyltransferase 1
MGI:95706
Synonyms
CD224, dwg, GGT, Ggtp
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:75561604-75586200 bp, + strand
From VEGA annotation of GRCm38

  24597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68450  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GGT1
Gene Tree: Ggt1

Human
homologs
GGT1, gamma-glutamyltransferase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2678
neXtProt AC: NX_P19440

Human Synonyms: CD224, D22S672, D22S732, GGT, GGT 1, GTG

Human Chr (Location): 22q11.23; chr22:24583750-24629005 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(2) Spontaneous(2) Targeted(4)
Genomic Mutations involving Ggt1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.
 
Human Diseases Modeled in Mice Using Ggt1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Ggt1 interacts with 32 markers (Mir17, Mir20b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (158)    Tissues (134)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 112
Northern blot 2
RT-PCR 34
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ggt1 ; ZFIN ggt1a    NEW 
Molecular
reagents
All nucleic(26) Genomic(6) cDNA(18) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034127 (Evidence)
Ensembl Gene Model ENSMUSG00000006345 (Evidence)
Entrez Gene 14598 (Evidence)
DFCI TC1575925, TC1743892
DoTS DT.491842, DT.91329392, DT.94350914, DT.94360260, DT.94390181, DT.97387249
NIA Mouse Gene Index U011662
EC 2.3.2.2, 3.4.19.13, 3.4.19.14
Consensus CDS Project CCDS23927.1
International Mouse Phenotyping Consortium Status Ggt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034127 VEGA Gene Model | MGI Sequence Detail 24597 C57BL/6J ±  kb
transcript OTTMUST00000086360 VEGA | MGI Sequence Detail 2140 Not Applicable 
polypeptide OTTMUSP00000046755 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(127) RefSeq(10) UniProt(15)
Polymorphisms
SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000101 Gamma-glutamyltranspeptidase
Protein Ontology PR:000001458 gamma-glutamyltranspeptidase 1
References
(Earliest) J:14610 Curto KA, et al., Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. J Histochem Cytochem. 1988 Feb;36(2):159-66
(Latest) J:202186 Yamada K, et al., Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary gamma-glutamyltransferase deficiency. Exp Anim. 2013;62(2):151-7
All references(72)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory