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Ggt1 Gene Detail
Summary
  • Symbol
    Ggt1
  • Name
    gamma-glutamyltransferase 1
  • Synonyms
    CD224, dwg, GGT, Ggtp
  • Feature Type
    protein coding gene
  • IDs
    MGI:95706
    NCBI Gene: 14598
  • Gene Overview
    MyGene.info: GGT1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:75561604-75586200 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      24597 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.55 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD224, D22S672, D22S732, GGT, GGT 1, GTG
  • Links
    NCBI Gene ID: 2678
    neXtProt AC: NX_P19440
    UniProt: P19440

  • Chr Location
    22q11.23; chr22:24583750-24629005 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 68450
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GGT1
  • Gene Tree
    Ggt1
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    168
  • Tissues
    141
  • cDNA Data
    17
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034127 VEGA Gene Model | MGI Sequence Detail 24597 C57BL/6J ±  kb
    transcript OTTMUST00000086360 VEGA | MGI Sequence Detail 2140 Not Applicable  
    polypeptide OTTMUSP00000046755 VEGA | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      116 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 6
      cDNA 18
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:252063 Ding D, et al., N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in gamma-glutamyl transferase 1 deficient mice. Aging (Albany NY). 2016 Apr;8(4):730-50
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory