Ggt1
Gene Detail

Symbol Name ID

Ggt1 gamma-glutamyltransferase 1 MGI:95706

Synonyms

CD224, dwg, GGT, Ggtp

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:75561604-75586200 bp, + strand From VEGA annotation of GRCm38   24597 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68450  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ggt1

Human homologs

Human Homolog		GGT1, gamma-glutamyltransferase 1
NCBI Gene ID		2678
neXtProt AC		NX_P19440
Human Synonyms		CD224, D22S672, D22S732, GGT, GGT 1, GTG
Human Chr (Location)		22q11.23; chr22:24979718-25024972 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(2) Spontaneous(1) Chemically induced(1)
 

Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.

 
Human Diseases Modeled Using Mouse Ggt1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cellular response to mechanical stimulus, cysteine biosynthetic process, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	gamma-glutamyltransferase activity, glutathione hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (158)    Tissues (133)    Images (15)
Theiler Stages: 1, 5, 11, 16, 17, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	112
Northern blot	2
RT-PCR	34

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(6) cDNA(18) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034127 (Evidence)
Ensembl Gene Model	ENSMUSG00000006345 (Evidence)
Entrez Gene	14598 (Evidence)
DFCI	TC1575925, TC1743892
DoTS	DT.491842, DT.91329392, DT.94350914, DT.94360260, DT.94390181, DT.97387249
NIA Mouse Gene Index	U011662
EC	2.3.2.2, 3.4.19.13, 3.4.19.14
Consensus CDS Project	CCDS23927.1
International Mouse Knockout Project Status	Ggt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034127	VEGA Gene Model | MGI Sequence Detail	24597	C57BL/6J
transcript	OTTMUST00000086360	VEGA | MGI Sequence Detail	2140	Not Applicable
polypeptide	OTTMUSP00000046755	VEGA | MGI Sequence Detail	568	Not Applicable

All sequences(118) RefSeq(2) UniProt(15)

Polymorphisms

SNPs within 2kb(117 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000101	Gamma-glutamyltranspeptidase
Protein Ontology	PR:000001458	gamma-glutamyltranspeptidase 1

References

(Earliest) J:14610 Curto KA, et al., Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. J Histochem Cytochem. 1988 Feb;36(2):159-66
(Latest) J:184021 Rugg-Gunn PJ, et al., Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell. 2012 Apr 17;22(4):887-901
All references(70)

Other accession IDs

MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942