Ggt1 MGI Mouse Gene Detail - MGI:95706 - gamma-glutamyltransferase 1

Symbol

Ggt1
Name

gamma-glutamyltransferase 1
Synonyms

CD224, dwg, GGT, Ggtp

Feature Type

protein coding gene
IDs

MGI:95706
NCBI Gene: 14598
Gene Overview

MyGene.info: GGT1
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr10:75561604-75586200 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.55 cM
Mapping Data

2 experiments

SNPs within 2kb

116 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95706	protein coding gene	Chr10:75561076-75586200 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017358	protein coding gene	Chr10:75735833-75760915 (+)
A/J	MGP_AJ_G0017335	protein coding gene	Chr10:73138961-73163580 (+)
AKR/J	MGP_AKRJ_G0017296	protein coding gene	Chr10:75101751-75126387 (+)
BALB/cJ	MGP_BALBcJ_G0017295	protein coding gene	Chr10:73333733-73358613 (+)
C3H/HeJ	MGP_C3HHeJ_G0017119	protein coding gene	Chr10:75139075-75163668 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017753	protein coding gene	Chr10:78422955-78447534 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015443	protein coding gene	Chr10:69598093-69623125 (+)
CAST/EiJ	MGP_CASTEiJ_G0016690	protein coding gene	Chr10:75455159-75481873 (+)
CBA/J	MGP_CBAJ_G0017091	protein coding gene	Chr10:81490328-81514948 (+)
DBA/2J	MGP_DBA2J_G0017196	protein coding gene	Chr10:72441791-72466599 (+)
FVB/NJ	MGP_FVBNJ_G0017189	protein coding gene	Chr10:71578240-71606303 (+)
LP/J	MGP_LPJ_G0017269	protein coding gene	Chr10:76230482-76256998 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017217	protein coding gene	Chr10:83589382-83613963 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017792	protein coding gene	Chr10:75124995-75152167 (+)
PWK/PhJ	MGP_PWKPhJ_G0016473	protein coding gene	Chr10:72263289-72288801 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016256	protein coding gene	Chr10:74371576-74399161 (+)
WSB/EiJ	MGP_WSBEiJ_G0016753	protein coding gene	Chr10:75098397-75122935 (+)

Human Ortholog

GGT1, gamma-glutamyltransferase 1

Vertebrate Orthologs

11

Human Ortholog

GGT1, gamma-glutamyltransferase 1
Orthology source: HomoloGene, HGNC
Synonyms

CD224, D22S672, D22S732, GGT, GGT 1, GGTD, GTG
Links

HGNC:4250

NCBI Gene ID: 2678

neXtProt AC: NX_P19440

UniProt: P19440
Chr Location

22q11.23; chr22:24583750-24629005 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68450
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GGT1
Gene Tree

Ggt1

Diseases

1 with human GGT1 associations

				Human Disease	Mouse Models
				gamma-glutamyl transpeptidase deficiency IDs gamma-glutamyl transpeptidase deficiency DOID:0111257 OMIM:231950 ORDO:33573 UMLS_CUI:C0268524

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

42 phenotypes from 3 alleles in 4 genetic backgrounds
6 phenotypes from multigenic genotypes
2 images
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

2
Spontaneous

2
Targeted

4
Genomic Mutations

2 involving Ggt1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

1

Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.

less

All GO Annotations

40
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

168
Tissues

141
cDNA Data

18
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ggt1

ZFIN ggt1a, ggt1b

less

Ggt1 interacts with 32 markers (Mir17, Mir20b, Mir22, ...) View All

less

All Sequences

103
RefSeq

16
UniProt

15
CCDS

CCDS23927.1

Ensembl

ENSMUSG00000006345 (Evidence)
NCBI Gene

14598

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006345	Ensembl Gene Model \| MGI Sequence Detail	24597	C57BL/6J	± kb
transcript	ENSMUST00000134503	Ensembl \| MGI Sequence Detail	2140	Not Applicable
polypeptide	ENSMUSP00000121312	Ensembl \| MGI Sequence Detail	568	Not Applicable

less

UniProt

15 Sequences
Protein Ontology

PR:000001458 glutathione hydrolase 1 proenzyme

(term hierarchy)
EC

2.3.2.2, 3.4.19.13, 3.4.19.14
InterPro Domains

IPR000101 Gamma-glutamyltranspeptidase

IPR029055 Nucleophile aminohydrolases, N-terminal

less

All nucleic 27

Genomic 6

cDNA 19

Primer pair 2

Microarray probesets 3

less

MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942

Summaries

All 83

Developmental Gene Expression 14

Gene Ontology 9

Phenotypes 33
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:252063 Ding D, et al., N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in gamma-glutamyl transferase 1 deficient mice. Aging (Albany NY). 2016 Apr;8(4):730-50

TSS for Ggt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94111	Chr10:75561269-75561279 (+)	-330 bp
Tssr94112	Chr10:75564086-75564165 (+)	2,522 bp
Tssr94113	Chr10:75564168-75564179 (+)	2,570 bp
Tssr94114	Chr10:75564181-75564197 (+)	2,585 bp
Tssr94115	Chr10:75564198-75564217 (+)	2,604 bp
Tssr94116	Chr10:75564584-75564601 (+)	2,989 bp
Tssr94117	Chr10:75566172-75566187 (+)	4,576 bp
Tssr94118	Chr10:75566219-75566241 (+)	4,626 bp
Tssr94119	Chr10:75566257-75566302 (+)	4,676 bp
Tssr94120	Chr10:75568630-75568639 (+)	7,031 bp
Tssr94121	Chr10:75568641-75568645 (+)	7,039 bp
Tssr94122	Chr10:75568648-75568673 (+)	7,057 bp
Tssr94123	Chr10:75571503-75571512 (+)	9,904 bp
Tssr94124	Chr10:75571522-75571532 (+)	9,923 bp
Tssr94125	Chr10:75571542-75571551 (+)	9,943 bp
Tssr94126	Chr10:75571553-75571586 (+)	9,966 bp
Tssr94127	Chr10:75573450-75573464 (+)	11,853 bp
Tssr94128	Chr10:75573492-75573501 (+)	11,893 bp
Tssr94129	Chr10:75573509-75573528 (+)	11,915 bp
Tssr94130	Chr10:75574200-75574225 (+)	12,609 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 12/03/2019 MGI 6.14