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Ggt1 Gene Detail
Summary
  • Symbol
    Ggt1
  • Name
    gamma-glutamyltransferase 1
  • Synonyms
    CD224, dwg, GGT, Ggtp
  • Feature Type
    protein coding gene
  • IDs
    MGI:95706
    NCBI Gene: 14598
  • Gene Overview
    MyGene.info: GGT1
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75564114-75586192 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95706
 protein coding gene Chr10:75561604-75586200 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017358
 protein coding gene Chr10:75735833-75760915 (+)
A/J MGP_AJ_G0017335
 protein coding gene Chr10:73138961-73163580 (+)
AKR/J MGP_AKRJ_G0017296
 protein coding gene Chr10:75101751-75126387 (+)
BALB/cJ MGP_BALBcJ_G0017295
 protein coding gene Chr10:73333733-73358613 (+)
C3H/HeJ MGP_C3HHeJ_G0017119
 protein coding gene Chr10:75139075-75163668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017753
 protein coding gene Chr10:78422955-78447534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015443
 protein coding gene Chr10:69598093-69623125 (+)
CAST/EiJ MGP_CASTEiJ_G0016690
 protein coding gene Chr10:75455159-75481873 (+)
CBA/J MGP_CBAJ_G0017091
 protein coding gene Chr10:81490328-81514948 (+)
DBA/2J MGP_DBA2J_G0017196
 protein coding gene Chr10:72441791-72466599 (+)
FVB/NJ MGP_FVBNJ_G0017189
 protein coding gene Chr10:71578240-71606303 (+)
LP/J MGP_LPJ_G0017269
 protein coding gene Chr10:76230482-76256998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017217
 protein coding gene Chr10:83589382-83613963 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017792
 protein coding gene Chr10:75124995-75152167 (+)
PWK/PhJ MGP_PWKPhJ_G0016473
 protein coding gene Chr10:72263289-72288801 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016256
 protein coding gene Chr10:74371576-74399161 (+)
WSB/EiJ MGP_WSBEiJ_G0016753
 protein coding gene Chr10:75098397-75122935 (+)



Homology
more
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GGT1, gamma-glutamyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD224, D22S672, D22S732, GGT, GGT 1, GGTD, GTG
  • Links
    NCBI Gene ID: 2678
    neXtProt AC: NX_P19440
    UniProt: P19440

  • Chr Location
    22q11.23; chr22:24583750-24629005 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 68450
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GGT1
  • Gene Tree
    Ggt1
Human Diseases
more
  • Diseases
    1 with human GGT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    168
  • Tissues
    141
  • cDNA Data
    18
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14598 NCBI Gene Model | MGI Sequence Detail 22079 C57BL/6J ±  kb
    transcript NM_008116 RefSeq | MGI Sequence Detail 2145 C57BL/6  
    polypeptide Q60928 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 6
      cDNA 19
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 33
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:252063 Ding D, et al., N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in gamma-glutamyl transferase 1 deficient mice. Aging (Albany NY). 2016 Apr;8(4):730-50
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/13/2019
    MGI 6.14     		The Jackson Laboratory