Ggt1 MGI Mouse Gene Detail - MGI:95706 - gamma-glutamyltransferase 1

Symbol

Ggt1
Name

gamma-glutamyltransferase 1
Synonyms

CD224, dwg, GGT, Ggtp

Feature Type

protein coding gene
IDs

MGI:95706
NCBI Gene: 14598
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr10:75397438-75422034 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.55 cM
Mapping Data

2 experiments

SNPs within 2kb

1168 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95706	protein coding gene	Chr10:75396910-75422034 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017358	protein coding gene	Chr10:75735833-75760915 (+)
A/J	MGP_AJ_G0017335	protein coding gene	Chr10:73138961-73163580 (+)
AKR/J	MGP_AKRJ_G0017296	protein coding gene	Chr10:75101751-75126387 (+)
BALB/cJ	MGP_BALBcJ_G0017295	protein coding gene	Chr10:73333733-73358613 (+)
C3H/HeJ	MGP_C3HHeJ_G0017119	protein coding gene	Chr10:75139075-75163668 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017753	protein coding gene	Chr10:78422955-78447534 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015443	protein coding gene	Chr10:69598093-69623125 (+)
CAST/EiJ	MGP_CASTEiJ_G0016690	protein coding gene	Chr10:75455159-75481873 (+)
CBA/J	MGP_CBAJ_G0017091	protein coding gene	Chr10:81490328-81514948 (+)
DBA/2J	MGP_DBA2J_G0017196	protein coding gene	Chr10:72441791-72466599 (+)
FVB/NJ	MGP_FVBNJ_G0017189	protein coding gene	Chr10:71578240-71606303 (+)
LP/J	MGP_LPJ_G0017269	protein coding gene	Chr10:76230482-76256998 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017217	protein coding gene	Chr10:83589382-83613963 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017792	protein coding gene	Chr10:75124995-75152167 (+)
PWK/PhJ	MGP_PWKPhJ_G0016473	protein coding gene	Chr10:72263289-72288801 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016256	protein coding gene	Chr10:74371576-74399161 (+)
WSB/EiJ	MGP_WSBEiJ_G0016753	protein coding gene	Chr10:75098397-75122935 (+)

Human Ortholog

GGT1, gamma-glutamyltransferase 1

Vertebrate Orthologs

12

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GGT1, gamma-glutamyltransferase 1
Synonyms

CD224, D22S672, D22S732, GGT, GGT 1, GGTD, GTG
Links

HGNC:4250

NCBI Gene ID: 2678

UniProt: P19440
Chr Location

22q11.23; chr22:24583750-24629005 (+) GRCh38

Human Ortholog

GGT2P, gamma-glutamyltransferase 2, pseudogene
Synonyms

GGT, GGT 2, GGT2
Links

HGNC:4251

NCBI Gene ID: 728441

UniProt: P36268
Chr Location

22q11.21; chr22:21207973-21259684 (-) GRCh38

Human Ortholog

GGT3P, gamma-glutamyltransferase 3 pseudogene
Synonyms

GGT3
Links

HGNC:4252

NCBI Gene ID: 2679

UniProt: A6NGU5
Chr Location

22q11.21; chr22:18773689-18791961 (-) GRCh38

Human Ortholog

GGTLC1, gamma-glutamyltransferase light chain 1
Synonyms

dJ831C21.1, dJ831C21.2, GGTL6, GGTLA3, GGTLA4
Links

HGNC:16437

NCBI Gene ID: 92086

UniProt: Q9BX51
Chr Location

20p11.21; chr20:23985050-23988779 (-) GRCh38

Human Ortholog

GGTLC2, gamma-glutamyltransferase light chain 2
Synonyms

GGTL4
Links

HGNC:18596

NCBI Gene ID: 91227

UniProt: Q14390
Chr Location

22q11.22; chr22:22644614-22647898 (+) GRCh38

Human Ortholog

GGTLC3, gamma-glutamyltransferase light chain family member 3
Synonyms

GGT
Links

HGNC:33426

NCBI Gene ID: 728226

UniProt: B5MD39
Chr Location

22q11.21; chr22:18516338-18518166 (-) GRCh38

MGI Vertebrate Homology

Ggt1 stringent orthology
6 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: GGT1, GGT2P, GGT3P, GGTLC1, GGTLC2, GGTLC3
Gene Tree

Ggt1

Diseases

1 with human GGT1 associations

				Human Disease	Mouse Models
				gamma-glutamyl transpeptidase deficiency IDs gamma-glutamyl transpeptidase deficiency DOID:0111257 MESH:C536836 OMIM:231950 ORDO:33573 UMLS_CUI:C0268524

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

59 phenotypes from 3 alleles in 4 genetic backgrounds
6 phenotypes from multigenic genotypes
2 images
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

2
Spontaneous

2
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Ggt1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutants may exhibit impaired growth, skeletal abnormalities, cataracts, lethargic behavior, premature greying, sterility, and shortened life span.

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All GO Annotations

57
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

142
cDNA Data

18
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ggt1

ZFIN ggt1a, ggt1b

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All Sequences

109
RefSeq

22
UniProt

15
CCDS

CCDS23927.1

Ensembl

ENSMUSG00000006345 (Evidence)
NCBI Gene

14598

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006345	Ensembl Gene Model \| MGI Sequence Detail	24597	C57BL/6J	± kb
transcript	ENSMUST00000006508	Ensembl \| MGI Sequence Detail	2167	Not Applicable
polypeptide	ENSMUSP00000006508	Ensembl \| MGI Sequence Detail	568	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000001458 glutathione hydrolase 1 proenzyme

(term hierarchy)
EC

2.3.2.2, 3.4.19.13, 3.4.19.14
InterPro Domains

IPR000101 Gamma-glutamyltranspeptidase

IPR043138 Gamma-glutamyltranspeptidase, large subunit, C-terminal domain

IPR043137 Gamma-glutamyltranspeptidase, small subunit

IPR029055 Nucleophile aminohydrolases, N-terminal
GlyGen

Q60928 6 sites, 6 N-linked glycans (5 sites)

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All nucleic 28

Genomic 6

cDNA 19

Primer pair 3

Microarray probesets 3

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MGD-MRK-10068, MGD-MRK-8921, MGI:2143665, MGI:94942

Summaries

All 98

Developmental Gene Expression 15

Gene Ontology 17

Phenotypes 40
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:336675 Yang Y, et al., m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis. Front Immunol. 2022;13:1094556

TSS for Ggt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94111	Chr10:75397103-75397113 (+)	-330 bp
Tssr94112	Chr10:75399920-75399999 (+)	2,522 bp
Tssr94113	Chr10:75400002-75400013 (+)	2,570 bp
Tssr94114	Chr10:75400015-75400031 (+)	2,585 bp
Tssr94115	Chr10:75400032-75400051 (+)	2,604 bp
Tssr94116	Chr10:75400418-75400435 (+)	2,989 bp
Tssr94117	Chr10:75402006-75402021 (+)	4,576 bp
Tssr94118	Chr10:75402053-75402075 (+)	4,626 bp
Tssr94119	Chr10:75402091-75402136 (+)	4,676 bp
Tssr94120	Chr10:75404464-75404473 (+)	7,031 bp
Tssr94121	Chr10:75404475-75404479 (+)	7,039 bp
Tssr94122	Chr10:75404482-75404507 (+)	7,057 bp
Tssr94123	Chr10:75407337-75407346 (+)	9,904 bp
Tssr94124	Chr10:75407356-75407366 (+)	9,923 bp
Tssr94125	Chr10:75407376-75407385 (+)	9,943 bp
Tssr94126	Chr10:75407387-75407420 (+)	9,966 bp
Tssr94127	Chr10:75409284-75409298 (+)	11,853 bp
Tssr94128	Chr10:75409326-75409335 (+)	11,893 bp
Tssr94129	Chr10:75409343-75409362 (+)	11,915 bp
Tssr94130	Chr10:75410034-75410059 (+)	12,609 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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