B4galt1
Gene Detail

Symbol Name ID

B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 MGI:95705

Synonyms

b1,4-Galactosyltransferase I, B-1,4-GalT1, beta 1,4-Galactosyltransferase I, beta-1,4-GalT1, GalT, Ggtb, Ggtb2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

20.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr4:40804602-40854005 bp, - strand From VEGA annotation of GRCm38   49404 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20378  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: beta-1,4-galactosyltransferase, B4GalT1-6 types
Gene Tree: B4galt1

Human homologs

Human Homolog		B4GALT1, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
NCBI Gene ID		2683
neXtProt AC		NX_P15291
Human Synonyms		B4GAL-T1, beta4Gal-T1, CDG2D, GGTB2, GT1, GTB
Human Chr (Location)		9p13; chr9:33110639-33167356 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human B4GALT1

Alleles and phenotypes

All alleles(55) : Targeted(6) Gene trapped(49)
 

Homozygotes for targeted null mutations exhibit growth retardation, low viability, excessive epithelial cell proliferation of skin and small intestine, sperm with reduced fertilizing capacity, birthing difficulty, and mammary gland defects.

 

Gene Ontology (GO) classifications

All GO classifications: (61 annotations)

Process	acute inflammatory response, angiogenesis involved in wound healing, ...
Component	basolateral plasma membrane, brush border membrane, ...
Function	alpha-tubulin binding, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (118)    Tissues (107)    Images (3)
Theiler Stages: 17, 19, 22, 25, 26, 28

Assay Type	Results
RNA in situ	96
Northern blot	22

cDNA source data(167)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(175) Genomic(1) cDNA(172) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006610 (Evidence)
Ensembl Gene Model	ENSMUSG00000028413 (Evidence)
Entrez Gene	14595 (Evidence)
UniGene	15622
DFCI	TC1622642, TC1723644
DoTS	DT.535043
NIA Mouse Gene Index	U024962
EC	2.4.1.-, 2.4.1.22, 2.4.1.38, 2.4.1.90
Consensus CDS Project	CCDS18051.1
International Mouse Knockout Project Status	B4galt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006610	VEGA Gene Model | MGI Sequence Detail	49404	C57BL/6J
transcript	OTTMUST00000015075	VEGA | MGI Sequence Detail	3983	Not Applicable
polypeptide	OTTMUSP00000006967	VEGA | MGI Sequence Detail	399	Not Applicable

All sequences(51) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(3) : SNPs(139 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003859	Galactosyltransferase, metazoa
Protein Ontology	PR:000004605	beta-1,4-galactosyltransferase 1

References

(Earliest) J:8592 Shaper NL, et al., The gene for galactosyltransferase maps to mouse chromosome 4. Cytogenet Cell Genet. 1987;44(1):18-21
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(90)

Other accession IDs

MGD-MRK-10067, MGI:2140118, MGI:891991