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Gdf9
Gene Detail
 Symbol
Name
ID
Gdf9
growth differentiation factor 9
MGI:95692
Synonyms Gdf-9
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:53431023-53437904 bp, + strand
From VEGA annotation of GRCm38

  6882 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3851  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: growth/differentiation factor, GDF9/GDF9B type
Gene Tree: Gdf9

Human
homologs
Human Homolog GDF9, growth differentiation factor 9
NCBI Gene ID 2661
neXtProt AC  NX_O60383
Human Chr (Location)  5q31.1; chr5:132861181-132866884 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Females homozygous for a targeted null mutation are sterile with a block in folliculogenesis. Mutant oocytes exhibit perinuclear organelle aggregation, unusual Golgi complexes, absence of cortical granules, and impaired granulosa cell connections.
 
Interactions
Gdf9 interacts with 76 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process negative regulation of cell growth, oocyte growth, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (40)    Tissues (5)    Images (3)
Theiler Stages: 2, 3, 19, 25, 27
Assay TypeResults
RT-PCR 40
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(9) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000055 (Evidence)
Ensembl Gene ModelENSMUSG00000018238 (Evidence)
Entrez Gene14566 (Evidence)
DFCITC1571857
DoTSDT.534571
NIA Mouse Gene IndexU012594
Consensus CDS ProjectCCDS24679.1
International Mouse Knockout Project StatusGdf9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000055 VEGA Gene Model | MGI Sequence Detail 6882 C57BL/6J ±  kb
transcript OTTMUST00000000144 VEGA | MGI Sequence Detail 1793 Not Applicable 
polypeptide OTTMUSP00000000077 VEGA | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015617 Growth differentiation factor-9
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000007925 growth/differentiation factor 9
References (Earliest) J:3946 McPherron AC, et al., GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. J Biol Chem. 1993 Feb 15;268(5):3444-9
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(75)
Other
accession IDs
MGD-MRK-10035, MGD-MRK-10045

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory