About   Help   FAQ
Gdf1 Gene Detail
Summary
  • Symbol
    Gdf1
  • Name
    growth differentiation factor 1
  • Synonyms
    Gdf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95683
    NCBI Gene: 14559
  • Gene Overview
    MyGene.info: GDF1
Location & Maps
more
  • Sequence Map
    Chr8:70329817-70331587 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1771 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GDF1, growth differentiation factor 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    GDF1, growth differentiation factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DORV, DTGA3, RAI
  • Links
    NCBI Gene ID: 2657
    neXtProt AC: NX_P27539

  • Chr Location
    19p12; chr19:18868546-18896144 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gdf1 mouse models; 4 with human GDF1 associations

Human Disease Mouse Models
       Pancreas, Annular   OMIM: 167750 View 1 model
       Conotruncal Heart Malformations; CTHM   OMIM: 217095
Right Atrial Isomerism; RAI   OMIM: 208530
Tetralogy of Fallot; TOF   OMIM: 187500
Transposition of the Great Arteries, Dextro-Looped 3; DTGA3   OMIM: 613854
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Gdf1
Homozygous null mice display partially penetrant late embryonic lethality, neonatal lethality, situs inversus, right pulmonary isomerism, and other left-right patterning defects, cardiac septal defects, annular pancreas, and abnormal spleen morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042299 VEGA Gene Model | MGI Sequence Detail 1771 C57BL/6J ±  kb
transcript OTTMUST00000111279 VEGA | MGI Sequence Detail 1349 Not Applicable  
polypeptide OTTMUSP00000062252 VEGA | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    100 from dbSNP Build 142
Molecular
Reagents
less
  • All nucleic 9
    cDNA 7
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10033, MGD-MRK-10036, MGI:2142519
References
more
  • Summaries
    All 45
    Developmental Gene Expression 25
    Diseases 1
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:10985 Lee SJ, Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Mol Endocrinol. 1990 Jul;4(7):1034-40
  • Latest
    J:222749 Bao MW, et al., Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. J Pathol. 2015 Jul;236(3):360-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory