Gdf1
Gene Detail

Symbol Name ID

Gdf1 growth differentiation factor 1 MGI:95683

Synonyms

Gdf-1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:70329817-70331587 bp, + strand From VEGA annotation of GRCm38   1771 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:105644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf1

Human homologs

Human Homolog		GDF1, growth differentiation factor 1
NCBI Gene ID		2657
neXtProt AC		NX_P27539
Human Synonyms		DORV, DTGA3
Human Chr (Location)		19p12; chr19:18979361-19006953 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human GDF1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice display partially penetrant late embryonic lethality, neonatal lethality, situs inversus, right pulmonary isomerism, and other left-right patterning defects, cardiac septal defects, annular pancreas, and abnormal spleen morphology.

 
Human Diseases Modeled Using Mouse Gdf1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process

endoderm development, in utero embryonic development, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (77)    Tissues (53)    Images (19)
Theiler Stages: 7, 9, 11, 12, 13, 14, 15, 17, 19, 20, 22, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	25
Northern blot	45
Western blot	2
RT-PCR	2

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000042299 (Evidence)
Ensembl Gene Model	ENSMUSG00000055694 (Evidence)
Entrez Gene	14559 (Evidence)
Consensus CDS Project	CCDS52571.1
International Mouse Knockout Project Status	Gdf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042299	VEGA Gene Model | MGI Sequence Detail	1771	C57BL/6J
transcript	OTTMUST00000111279	VEGA | MGI Sequence Detail	1349	Not Applicable
polypeptide	OTTMUSP00000062252	VEGA | MGI Sequence Detail	357	Not Applicable

All sequences(19) RefSeq(4)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000007917	embryonic growth/differentiation factor 1

References

(Earliest) J:10985 Lee SJ, Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Mol Endocrinol. 1990 Jul;4(7):1034-40
(Latest) J:187958 Yoshiba S, et al., Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science. 2012 Oct 12;338(6104):226-31
All references(40)

Other accession IDs

MGD-MRK-10033, MGD-MRK-10036, MGI:2142519