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Gdf1
Gene Detail
 Symbol
Name
ID
Gdf1
growth differentiation factor 1
MGI:95683
Synonyms Gdf-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70329817-70331587 bp, + strand
From VEGA annotation of GRCm38

  1771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf1

Human
homologs
Human Homolog GDF1, growth differentiation factor 1
NCBI Gene ID 2657
neXtProt AC  NX_P27539
Human Synonyms  DORV, DTGA3, RAI
Human Chr (Location)  19p12; chr19:18868552-18896144 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human GDF1
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous null mice display partially penetrant late embryonic lethality, neonatal lethality, situs inversus, right pulmonary isomerism, and other left-right patterning defects, cardiac septal defects, annular pancreas, and abnormal spleen morphology.
 
Human Diseases Modeled Using Mouse Gdf1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process endoderm development, in utero embryonic development, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (77)    Tissues (53)    Images (19)
Theiler Stages: 7, 9, 11, 12, 13, 14, 15, 17, 19, 20, 22, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 25
Northern blot 45
Western blot 2
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000042299 (Evidence)
Ensembl Gene ModelENSMUSG00000055694 (Evidence)
Entrez Gene14559 (Evidence)
Consensus CDS ProjectCCDS52571.1
International Mouse Knockout Project StatusGdf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042299 VEGA Gene Model | MGI Sequence Detail 1771 C57BL/6J ±  kb
transcript OTTMUST00000111279 VEGA | MGI Sequence Detail 1349 Not Applicable 
polypeptide OTTMUSP00000062252 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4)
Polymorphisms SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000007917 embryonic growth/differentiation factor 1
References (Earliest) J:10985 Lee SJ, Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Mol Endocrinol. 1990 Jul;4(7):1034-40
(Latest) J:200709 Botilde Y, et al., Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Dev Biol. 2013 Sep 1;381(1):203-12
All references(41)
Other
accession IDs
MGD-MRK-10033, MGD-MRK-10036, MGI:2142519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory