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Gdf1
Gene Detail
Symbol

Name
ID
Gdf1
growth differentiation factor 1
MGI:95683
Synonyms
Gdf-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70329817-70331587 bp, + strand
From VEGA annotation of GRCm38

  1771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf1

Human
homologs
Human Homolog GDF1, growth differentiation factor 1
NCBI Gene ID 2657
neXtProt AC  NX_P27539
Human Synonyms  DORV, DTGA3, RAI
Human Chr (Location)  19p12; chr19:18868552-18896144 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human GDF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous null mice display partially penetrant late embryonic lethality, neonatal lethality, situs inversus, right pulmonary isomerism, and other left-right patterning defects, cardiac septal defects, annular pancreas, and abnormal spleen morphology.
 
Human Diseases Modeled Using Mouse Gdf1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gdf1 interacts with 12 markers (Mir16-2, Mir208a, Mir208b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process BMP signaling pathway, cell development, ...
Component extracellular space
Function cytokine activity, transforming growth factor beta receptor binding
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (77)    Tissues (54)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 25
Northern blot 45
Western blot 2
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000042299 (Evidence)
Ensembl Gene ModelENSMUSG00000055694 (Evidence)
Entrez Gene14559 (Evidence)
Consensus CDS ProjectCCDS52571.1
International Mouse Knockout Project StatusGdf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042299 VEGA Gene Model | MGI Sequence Detail 1771 C57BL/6J ±  kb
transcript OTTMUST00000111279 VEGA | MGI Sequence Detail 1349 Not Applicable 
polypeptide OTTMUSP00000062252 VEGA | MGI Sequence Detail 357 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(4)
Polymorphisms
SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000007917 embryonic growth/differentiation factor 1
References
(Earliest) J:10985 Lee SJ, Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Mol Endocrinol. 1990 Jul;4(7):1034-40
(Latest) J:214665 Fuller K, et al., Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway. Dev Biol. 2014 Jul 15;391(2):182-95
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10033, MGD-MRK-10036, MGI:2142519

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory