About   Help   FAQ
Gdf1 Gene Detail
Summary
  • Symbol
    Gdf1
  • Name
    growth differentiation factor 1
  • Synonyms
    Gdf-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95683
    NCBI Gene: 14559
  • Gene Overview
    MyGene.info: GDF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:70329817-70331587 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1771 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GDF1, growth differentiation factor 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    GDF1, growth differentiation factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CHTD6, DORV, DTGA3, RAI
  • Links
    NCBI Gene ID: 2657
    neXtProt AC: NX_P27539
    UniProt: P27539

  • Chr Location
    19p13.11; chr19:18868546-18896144 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gdf1 mouse models; 4 with human GDF1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 3 genetic backgrounds
    28 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partially penetrant late embryonic lethality, neonatal lethality, situs inversus, right pulmonary isomerism, and other left-right patterning defects, cardiac septal defects, annular pancreas, and abnormal spleen morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042299 VEGA Gene Model | MGI Sequence Detail 1771 C57BL/6J ±  kb
    transcript OTTMUST00000111279 VEGA | MGI Sequence Detail 1349 Not Applicable  
    polypeptide OTTMUSP00000062252 VEGA | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      100 from dbSNP Build 142
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-10033, MGD-MRK-10036, MGI:2142519
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:10985 Lee SJ, Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily. Mol Endocrinol. 1990 Jul;4(7):1034-40
    • Latest
      J:261380 Concepcion D, et al., Tbx6 controls left-right asymmetry through regulation of Gdf1. Biol Open. 2018 May 4;7(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory