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Gpd1 Gene Detail
Summary
  • Symbol
    Gpd1
  • Name
    glycerol-3-phosphate dehydrogenase 1 (soluble)
  • Synonyms
    Gdc1, Gdc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95679
    NCBI Gene: 14555
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99717587-99725014 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.13 cM, cytoband F1-F3
  • Mapping Data
    72 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95679
protein coding gene Chr15:99717515-99725014 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022341
protein coding gene Chr15:101594340-101601829 (+)
A/J MGP_AJ_G0022299
protein coding gene Chr15:97533403-97540887 (+)
AKR/J MGP_AKRJ_G0022275
protein coding gene Chr15:100538423-100545911 (+)
BALB/cJ MGP_BALBcJ_G0022305
protein coding gene Chr15:97718644-97726088 (+)
C3H/HeJ MGP_C3HHeJ_G0022073
protein coding gene Chr15:100605492-100612976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022750
protein coding gene Chr15:105376374-105383977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020276
protein coding gene Chr15:93426057-93433949 (+)
CAST/EiJ MGP_CASTEiJ_G0021597
protein coding gene Chr15:101474478-101481826 (+)
CBA/J MGP_CBAJ_G0022042
protein coding gene Chr15:108968553-108975997 (+)
DBA/2J MGP_DBA2J_G0022169
protein coding gene Chr15:96972002-96979492 (+)
FVB/NJ MGP_FVBNJ_G0022149
protein coding gene Chr15:95963264-95970759 (+)
LP/J MGP_LPJ_G0022240
protein coding gene Chr15:101738659-101746380 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022169
protein coding gene Chr15:112851712-112859156 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022765
protein coding gene Chr15:100654040-100661530 (+)
PWK/PhJ MGP_PWKPhJ_G0021336
protein coding gene Chr15:97114880-97122368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021171
protein coding gene Chr15:100496918-100504483 (+)
WSB/EiJ MGP_WSBEiJ_G0021648
protein coding gene Chr15:101169839-101177329 (+)



Homology
more
  • Human Ortholog
    GPD1, glycerol-3-phosphate dehydrogenase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GPD1, glycerol-3-phosphate dehydrogenase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPD-C, GPDH-C, HTGTI
  • Links
    NCBI Gene ID: 2819
    neXtProt AC: NX_P21695
    UniProt: P21695

  • Chr Location
    12q13.12; chr12:50103819-50111320 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    4
  • Genomic Mutations
    3 involving Gpd1
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a spontaneous mutation are viable and phenotypically normal but show loss of glycerol-3-phosphate dehydrogenase 1 activity in adult tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14555 NCBI Gene Model | MGI Sequence Detail 7428 C57BL/6J ±  kb
transcript NM_010271 RefSeq | MGI Sequence Detail 2798 C57BL/6  
polypeptide P13707 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008169 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
  • EC
  • InterPro Domains
    IPR013328 6-phosphogluconate dehydrogenase, domain 2
    IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
    IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
    IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
    IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
    IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
    IPR036291 NAD(P)-binding domain superfamily
Molecular
Reagents
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  • All nucleic 196
    Genomic 12
    cDNA 180
    Primer pair 2
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-10025, MGD-MRK-10027, MGI:2146056
References
more
  • Summaries
    All 120
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 9
    Phenotypes 29
  • Earliest
    J:5309 Kozak LP, Genetic control of -glycerolphosphate dehydrogenase in mouse brain. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3170-4
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory