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Gpd1 Gene Detail
Summary
  • Symbol
    Gpd1
  • Name
    glycerol-3-phosphate dehydrogenase 1 (soluble)
  • Synonyms
    Gdc1, Gdc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95679
    NCBI Gene: 14555
Location & Maps
more
  • Sequence Map
    Chr15:99717515-99725005 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7491 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPD1, glycerol-3-phosphate dehydrogenase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GPD1, glycerol-3-phosphate dehydrogenase 1
    Orthology source: HomoloGene
  • Synonyms
    GPD-C, GPDH-C, HTGTI
  • Links
    NCBI Gene ID: 2819
    neXtProt AC: NX_P21695

  • Chr Location
    12q13.12; chr12:50103819-50111320 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GPD1 associations

Human Disease Mouse Models
       Hypertriglyceridemia, Transient Infantile; HTGTI   OMIM: 614480
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    4
  • Genomic Mutations
    3 involving Gpd1
  • Incidental Mutations
Mice homozygous for a spontaneous mutation are viable and phenotypically normal but show loss of glycerol-3-phosphate dehydrogenase 1 activity in adult tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034997 VEGA Gene Model | MGI Sequence Detail 7491 C57BL/6J ±  kb
transcript OTTMUST00000088996 VEGA | MGI Sequence Detail 2861 Not Applicable  
polypeptide OTTMUSP00000048574 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    142 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008169 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
  • EC
  • InterPro Domains
    IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
    IPR013328 6-phosphogluconate dehydrogenase, domain 2
    IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
    IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
    IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
    IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
    IPR016040 NAD(P)-binding domain
Molecular
Reagents
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  • All nucleic 195
    Genomic 12
    cDNA 179
    Primer pair 2
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-10025, MGD-MRK-10027, MGI:2146056
References
more
  • Summaries
    All 100
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:5309 Kozak LP, Genetic control of -glycerolphosphate dehydrogenase in mouse brain. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3170-4
  • Latest
    J:220338 Sato T, et al., Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise. Biochem Biophys Res Commun. 2015 Feb 20;457(4):653-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory