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Gpd1
Gene Detail
Symbol

Name
ID
Gpd1
glycerol-3-phosphate dehydrogenase 1 (soluble)
MGI:95679
Synonyms
Gdc1, Gdc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.13 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(72)
Sequence Map
Chr15:99717515-99725005 bp, + strand
From VEGA annotation of GRCm38

  7491 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5593  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GPD1
Protein SuperFamily: glycerol-3-phosphate dehydrogenase (NAD)
Gene Tree: Gpd1

Human
homologs
GPD1, glycerol-3-phosphate dehydrogenase 1 (soluble)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2819
neXtProt AC: NX_P21695

Human Synonyms: GPD-C, GPDH-C, HTGTI

Human Chr (Location): 12q13.12; chr12:50103819-50111320 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GPD1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Radiation induced(1) Spontaneous(1) Targeted(2) Transgenic(4)
Genomic Mutations involving Gpd1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation are viable and phenotypically normal but show loss of glycerol-3-phosphate dehydrogenase 1 activity in adult tissues.
 
Phenotype Images(2)
Interactions
Gpd1 interacts with 211 markers (Mir10b, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (405)    Tissues (340)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 405
cDNA source data(177)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GPD1 ; Xenbase gpd1 ; ZFIN gpd1b    NEW 
Molecular
reagents
All nucleic(195) Genomic(12) cDNA(179) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000034997 (Evidence)
Ensembl Gene Model ENSMUSG00000023019 (Evidence)
Entrez Gene 14555 (Evidence)
UniGene 252391
DFCI TC1572368, TC1753274
DoTS DT.101158640, DT.101408419, DT.55107691
NIA Mouse Gene Index U016647
EC 1.1.1.8
Consensus CDS Project CCDS27828.1
International Mouse Phenotyping Consortium Status Gpd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034997 VEGA Gene Model | MGI Sequence Detail 7491 C57BL/6J ±  kb
transcript OTTMUST00000088996 VEGA | MGI Sequence Detail 2861 Not Applicable 
polypeptide OTTMUSP00000048574 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(21) : PCR(4) RFLP(17) SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
InterPro IPR013328 Dehydrogenase, multihelical
InterPro IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
InterPro IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
InterPro IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
InterPro IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008169 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
References
(Earliest) J:5309 Kozak LP, Genetic control of -glycerolphosphate dehydrogenase in mouse brain. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3170-4
(Latest) J:220338 Sato T, et al., Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise. Biochem Biophys Res Commun. 2015 Feb 20;457(4):653-8
All references(103)
Other
accession IDs
MGD-MRK-10025, MGD-MRK-10027, MGI:2146056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory