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Gda
Gene Detail
Symbol

Name
ID
Gda
guanine deaminase
MGI:95678
Feature Type
protein coding gene
Genetic Map
Chromosome 19
14.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:21391307-21473445 bp, - strand
From VEGA annotation of GRCm38

  82139 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GDA
Protein SuperFamily: metal-dependent hydrolase (amidohydrolase)
Gene Tree: Gda

Human
homologs
GDA, guanine deaminase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9615
neXtProt AC: NX_Q9Y2T3

Human Synonyms: CYPIN, GUANASE, NEDASIN

Human Chr (Location): 9q21.13; chr9:72114595-72259059 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Gda interacts with 392 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process guanine catabolic process, positive regulation of microtubule polymerization
Component extracellular exosome
Function guanine deaminase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (117)    Tissues (99)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(58)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000028318 (Evidence)
Ensembl Gene Model ENSMUSG00000058624 (Evidence)
Entrez Gene 14544 (Evidence)
UniGene 45054
DFCI TC1577122, TC1581927
DoTS DT.101166212, DT.101359497, DT.101362496, DT.101720441, DT.87067836, DT.91579760
NIA Mouse Gene Index U038910
EC 3.5.4.3
Consensus CDS Project CCDS29698.1
International Mouse Phenotyping Consortium Status Gda
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028318 VEGA Gene Model | MGI Sequence Detail 82139 C57BL/6J ±  kb
transcript OTTMUST00000070187 VEGA | MGI Sequence Detail 5428 Not Applicable 
polypeptide OTTMUSP00000035739 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(8)
Polymorphisms
SNPs within 2kb(1622 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR014311 Guanine deaminase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000007911 guanine deaminase
References
(Earliest) J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGD-MRK-10024, MGI:2147637, MGI:2147689

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory