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Gcg
Gene Detail
 Symbol
Name
ID
Gcg
glucagon
MGI:95674
Synonyms GLP-1, Glu, glucagon-like peptide I, PPG
Feature Type protein coding gene
Genetic Map
Chromosome 2
35.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr2:62474530-62483650 bp, - strand
From VEGA annotation of GRCm38

  9121 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1553  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glucagon
Gene Tree: Gcg

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit islet alpha cell hyperplasia and increased body weight.
 
Interactions
Gcg interacts with 103 markers (Mir22, Mir26a-1, Mir32, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, negative regulation of apoptotic process, ...
Component cytoplasm, extracellular region, ...
Function glucagon receptor binding, hormone activity
External Resources: FuncBase
Expression
Literature Summary: (309 records)
Data Summary: Results (231)    Tissues (98)    Images (128)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 135
RNA in situ 6
RT-PCR 90
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(38) Primer pair(10)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012783 (Evidence)
Ensembl Gene ModelENSMUSG00000000394 (Evidence)
Entrez Gene14526 (Evidence)
UniGene45494
DFCITC1574634
DoTSDT.523243
NIA Mouse Gene IndexU022675
Consensus CDS ProjectCCDS16066.1
International Mouse Knockout Project StatusGcg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012783 VEGA Gene Model | MGI Sequence Detail 9121 C57BL/6J ±  kb
transcript OTTMUST00000030606 VEGA | MGI Sequence Detail 1088 Not Applicable 
polypeptide OTTMUSP00000013741 VEGA | MGI Sequence Detail 180 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms RFLP(5) : SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
InterPro IPR015550 Glucagon-like
Protein Ontology PR:000007891 glucagon
References (Earliest) J:8667 Lalley PA, et al., Mapping polypeptide hormone genes in the mouse: somatostatin, glucagon, calcitonin, and parathyroid hormone. Cytogenet Cell Genet. 1987;44(2-3):92-7
(Latest) J:208719 Tsai MJ, et al., TCTP is essential for beta-cell proliferation and mass expansion during development and beta-cell adaptation in response to insulin resistance. Endocrinology. 2014 Feb;155(2):392-404
All references(391)
Other
accession IDs
MGD-MRK-10020

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory