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Gbp2b
Gene Detail
Symbol

Name
ID
Gbp2b
guanylate binding protein 2b
MGI:95666
Synonyms
Gbp1, Gbp-1, Mag-1, Mpa1, Mpa-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
66.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr3:142594847-142619179 bp, + strand
From VEGA annotation of GRCm38

  24333 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137233  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee

HCOP human homology predictions: GBP3
Protein SuperFamily: guanine nucleotide-binding protein 1

Human
homologs
GBP3, guanylate binding protein 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2635
neXtProt AC: NX_Q9H0R5

Human Chr (Location): 1p22.2; chr1:89006677-89022880 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Gbp2b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased susceptibility to bacterial infection.
 
Interactions
Gbp2b interacts with 166 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process adhesion of symbiont to host, cellular response to interferon-beta, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function GMP binding, GTPase activity, ...
External Resources: FuncBase
Expression
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gbp1    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035259 (Evidence)
Entrez Gene 14468 (Evidence)
UniGene 457978
DFCI TC1588406
DoTS DT.101708357, DT.55164978
NIA Mouse Gene Index U237744
Consensus CDS Project CCDS38658.1
International Mouse Phenotyping Consortium Status Gbp2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035259 VEGA Gene Model | MGI Sequence Detail 24333 C57BL/6J ±  kb
transcript OTTMUST00000089923 VEGA | MGI Sequence Detail 2823 Not Applicable 
polypeptide OTTMUSP00000049196 VEGA | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(10) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(433 from dbSNP Build 137)    SNPs within 2kb including multiple locations(435)
Protein-related
information
ResourceIDDescription
InterPro IPR003191 Guanylate-binding protein, C-terminal
InterPro IPR015894 Guanylate-binding protein, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000007874 interferon-induced guanylate-binding protein 1
References
(Earliest) J:7579 Staeheli P, et al., Genetic control of interferon action: mouse strain distribution and inheritance of an induced protein with guanylate-binding property. Virology. 1984 Aug;137(1):135-42
(Latest) J:197024 Selleck EM, et al., Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog. 2013 Apr;9(4):e1003320
All references(46)
Other
accession IDs
MGD-MRK-10008, MGD-MRK-10009, MGD-MRK-12400, MGD-MRK-12402, MGI:97071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory