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Gbp2b Gene Detail
Summary
  • Symbol
    Gbp2b
  • Name
    guanylate binding protein 2b
  • Synonyms
    Gbp1, Gbp-1, Mag-1, Mpa1, Mpa-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95666
    NCBI Gene: 14468
Location & Maps
more
  • Sequence Map
    Chr3:142594847-142619179 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24333 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    GBP3, guanylate binding protein 3
  • Vertebrate Orthologs
    3
  • Human Ortholog
    GBP3, guanylate binding protein 3
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2635
    neXtProt AC: NX_Q9H0R5

  • Chr Location
    1p22.2; chr1:89006677-89022880 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gbp2b
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035259 VEGA Gene Model | MGI Sequence Detail 24333 C57BL/6J ±  kb
transcript OTTMUST00000089923 VEGA | MGI Sequence Detail 2823 Not Applicable  
polypeptide OTTMUSP00000049196 VEGA | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    422 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein, C-terminal
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 14
    Genomic 1
    cDNA 11
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10008, MGD-MRK-10009, MGD-MRK-12400, MGD-MRK-12402, MGI:97071
References
more
  • Summaries
    All 43
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:7579 Staeheli P, et al., Genetic control of interferon action: mouse strain distribution and inheritance of an induced protein with guanylate-binding property. Virology. 1984 Aug;137(1):135-42
  • Latest
    J:197024 Selleck EM, et al., Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii. PLoS Pathog. 2013 Apr;9(4):e1003320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory