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Gata3
Gene Detail
 Symbol
Name
ID
Gata3
GATA binding protein 3
MGI:95663
Synonyms Gata-3, jal
Feature Type protein coding gene
Genetic Map
Chromosome 2
6.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:9857078-9890034 bp, - strand
From VEGA annotation of GRCm38

  32957 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata3

Human
homologs
Human Homolog GATA3, GATA binding protein 3
NCBI Gene ID 2625
neXtProt AC  NX_P23771
Human Synonyms  HDR, HDRS
Human Chr (Location)  10p15; chr10:8045473-8075201 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GATA3
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(2) Spontaneous(1) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation is embryonic lethal and show a variety of embryonic defects. T cell development is impaired when the locus is conditionally. Mice with a spontaneous mutation exhibit partial hair loss and various defects in hair structure and in hair growth cycle regulation.
 
Human Diseases Modeled Using Mouse Gata3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gata3 interacts with 248 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (164 annotations)
Process anatomical structure formation involved in morphogenesis, aortic valve morphogenesis, ...
Component cell, intracellular, ...
Function core promoter proximal region sequence-specific DNA binding, core promoter sequence-specific DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (177 records)
Data Summary: Results (763)    Tissues (419)    Images (184)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 37
RNA in situ 663
In situ reporter (knock in) 20
Northern blot 4
RT-PCR 39
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) Genomic(6) cDNA(85) Primer pair(8) Other(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011129 (Evidence)
Ensembl Gene ModelENSMUSG00000015619 (Evidence)
Entrez Gene14462 (Evidence)
UniGene313866
DFCITC1578659
DoTSDT.101353389, DT.487714, DT.493876
PDB3DFV, 3DFX
Consensus CDS ProjectCCDS15674.1
International Mouse Knockout Project StatusGata3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011129 VEGA Gene Model | MGI Sequence Detail 32957 C57BL/6J ±  kb
transcript OTTMUST00000026063 VEGA | MGI Sequence Detail 3215 Not Applicable 
polypeptide OTTMUSP00000011932 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(6)
Polymorphisms SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016374 Transcription factor, GATA-1/2/3
InterPro IPR000679 Zinc finger, GATA-type
InterPro IPR013088 Zinc finger, NHR/GATA-type
Protein Ontology PR:000001941 trans-acting T-cell-specific transcription factor GATA-3
References (Earliest) J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
(Latest) J:210327 Yagi R, et al., The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells. Immunity. 2014 Mar 20;40(3):378-88
All references(317)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10000, MGD-MRK-10004, MGI:2181648

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory