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Gata3 Gene Detail
Summary
  • Symbol
    Gata3
  • Name
    GATA binding protein 3
  • Synonyms
    Gata-3, jal
  • Feature Type
    protein coding gene
  • IDs
    MGI:95663
    NCBI Gene: 14462
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:9861889-9894845 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 6.69 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95663
protein coding gene Chr2:9861889-9894845 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025333
protein coding gene Chr2:7190687-7226840 (-)
A/J MGP_AJ_G0025310
protein coding gene Chr2:6869096-6903015 (-)
AKR/J MGP_AKRJ_G0025279
protein coding gene Chr2:7084390-7118820 (-)
BALB/cJ MGP_BALBcJ_G0025306
protein coding gene Chr2:6871832-6905455 (-)
C3H/HeJ MGP_C3HHeJ_G0025066
protein coding gene Chr2:7042168-7075257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025748
protein coding gene Chr2:7384694-7421945 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023162
protein coding gene Chr2:6381660-6414305 (-)
CAST/EiJ MGP_CASTEiJ_G0024529
protein coding gene Chr2:7062562-7096805 (-)
CBA/J MGP_CBAJ_G0025045
protein coding gene Chr2:7668863-7710117 (-)
DBA/2J MGP_DBA2J_G0025177
protein coding gene Chr2:6796470-6835451 (-)
FVB/NJ MGP_FVBNJ_G0025139
protein coding gene Chr2:6741934-6777201 (-)
LP/J MGP_LPJ_G0025263
protein coding gene Chr2:7064601-7100449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025171
protein coding gene Chr2:7675014-7710154 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025806
protein coding gene Chr2:7036893-7073255 (-)
PWK/PhJ MGP_PWKPhJ_G0024280
protein coding gene Chr2:6783932-6817977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024080
protein coding gene Chr2:7026149-7060206 (-)
WSB/EiJ MGP_WSBEiJ_G0024599
protein coding gene Chr2:7136899-7170210 (-)



Homology
more
  • Human Ortholog
    GATA3, GATA binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATA3, GATA binding protein 3
  • Synonyms
    HDR, HDRS
  • Links
    NCBI Gene ID: 2625
    neXtProt AC: NX_P23771
    UniProt: P23771

  • Chr Location
    10p14; chr10:8045333-8075198 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Gata3 mouse models; 4 with human GATA3 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    184 phenotypes from 12 alleles in 22 genetic backgrounds
    11 phenotypes from multigenic genotypes
    174 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes embryonic lethality and a variety of embryonic defects. Homozygotes for a spontaneous allele show partial hair loss and defects in hair structure and hair growth cycle regulation. Homozygotes for a null allele show severe cardiac outflow tract defects, such as ventricular septal defect, double outlet right ventricle, aortic arch anomalies and persistent truncus arteriosus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14462 NCBI Gene Model | MGI Sequence Detail 32957 C57BL/6J ±  kb
    transcript NM_001417046 RefSeq | MGI Sequence Detail 3321 ZRU/MplStud  
    polypeptide P23772 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 129
      Genomic 6
      cDNA 89
      Primer pair 16
      Other 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10000, MGD-MRK-10004, MGI:2181648
    References
    more
    • Summaries
      All 551
      Developmental Gene Expression 303
      Diseases 2
      Gene Ontology 73
      Phenotypes 174
    • Earliest
      J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
    • Latest
      J:345248 Tran HN, et al., Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory