Gata3
Gene Detail

Symbol Name ID

Gata3 GATA binding protein 3 MGI:95663

Synonyms

Gata-3

Feature Type

protein coding gene

Genetic Map

Chromosome 2

6.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:9857078-9890034 bp, - strand From VEGA annotation of GRCm38   32957 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1550  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor, GATA-1/2/3 types
Gene Tree: Gata3

Human homologs

Human Homolog		GATA3, GATA binding protein 3
NCBI Gene ID		2625
neXtProt AC		NX_P23771
Human Synonyms		HDR, HDRS
Human Chr (Location)		10p15; chr10:8096667-8117164 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GATA3

Alleles and phenotypes

All alleles(14) : Targeted(12) Gene trapped(2)
 

Homozygous inactivation is embryonic lethal. Embryos exhibit growth retardation, deformities of the brain, spinal cord and inner ear, and impaired fetal liver hematopoiesis. T cell development is impaired when the locus is conditionally inactivated during this process.

 
Human Diseases Modeled Using Mouse Gata3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (157 annotations)

Process	anatomical structure formation involved in morphogenesis, aortic valve morphogenesis, ...
Component	nuclear chromatin, nucleus
Function	core promoter proximal region sequence-specific DNA binding, core promoter sequence-specific DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (160 records)
Data Summary: Results (698)    Tissues (382)    Images (143)
Theiler Stages: 2, 3, 4, 5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	37
RNA in situ	620
In situ reporter (knock in)	4
Northern blot	4
RT-PCR	33

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(6) cDNA(24) Primer pair(7) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011129 (Evidence)
Ensembl Gene Model	ENSMUSG00000015619 (Evidence)
Entrez Gene	14462 (Evidence)
DFCI	TC1578659
DoTS	DT.101353389, DT.487714, DT.493876
PDB	3DFV, 3DFX
Consensus CDS Project	CCDS15674.1
International Mouse Knockout Project Status	Gata3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011129	VEGA Gene Model | MGI Sequence Detail	32957	C57BL/6J
transcript	OTTMUST00000026063	VEGA | MGI Sequence Detail	3215	Not Applicable
polypeptide	OTTMUSP00000011932	VEGA | MGI Sequence Detail	443	Not Applicable

All sequences(44) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016374	Transcription factor, GATA-1/2/3
InterPro	IPR000679	Zinc finger, GATA-type
InterPro	IPR013088	Zinc finger, NHR/GATA-type
Protein Ontology	PR:000001941	trans-acting T-cell-specific transcription factor GATA-3

References

(Earliest) J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
(Latest) J:195075 Xiong Y, et al., Thpok-independent repression of Runx3 by Gata3 during CD4(+) T-cell differentiation in the thymus. Eur J Immunol. 2013 Apr;43(4):918-28
All references(284)

Other accession IDs

MGD-MRK-10000, MGD-MRK-10004