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Gas6
Gene Detail
Symbol

Name
ID
Gas6
growth arrest specific 6
MGI:95660
Synonyms
Gas-6, GAS 6, growth arrest-specific
Feature Type
protein coding gene
Genetic Map
Chromosome 8
6.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:13465374-13494535 bp, - strand
From NCBI annotation of GRCm38

  29162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GAS6
Protein SuperFamily: plasma protein S
Gene Tree: Gas6

Human
homologs
GAS6, growth arrest-specific 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2621
neXtProt AC: NX_Q14393

Human Synonyms: AXLLG, AXSF

Human Chr (Location): 13q34; chr13:113820549-113864103 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice are protected against arterial and venous thrombosis, and though platelet aggregation is impaired, spontaneous or excess trauma-induced bleeding is not observed.
 
Interactions
Gas6 interacts with 33 markers (Mir103-1, Mir186, Mir190b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process activation of protein kinase B activity, apoptotic cell clearance, ...
Component cytoplasm, extracellular exosome, ...
Function binding, bridging, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (247)    Tissues (66)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 238
RT-PCR 9
cDNA source data(149)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gas6 ; ZFIN gas6    NEW 
Molecular
reagents
All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031451 (Evidence)
Entrez Gene 14456 (Evidence)
UniGene 3982
DFCI TC1575666
DoTS DT.532106
NIA Mouse Gene Index U029601
Consensus CDS Project CCDS40232.1
International Mouse Phenotyping Consortium Status Gas6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14456 NCBI Gene Model | MGI Sequence Detail 29162 C57BL/6J ±  kb
transcript NM_019521 RefSeq | MGI Sequence Detail 2594 C57BL/6 
polypeptide Q61592 UniProt | EBI | MGI Sequence Detail 674 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000007853 growth arrest-specific protein 6
Graphical View of Protein Domain Structure
References
(Earliest) J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
(Latest) J:220148 Salian-Mehta S, et al., Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):164-70
All references(70)
Other
accession IDs
MGD-MRK-9991, MGD-MRK-9997

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory