About   Help   FAQ
Gas6
Gene Detail
 Symbol
Name
ID
Gas6
growth arrest specific 6
MGI:95660
Synonyms Gas-6, GAS 6, growth arrest-specific
Feature Type protein coding gene
Genetic Map
Chromosome 8
6.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:13465374-13494535 bp, - strand
From NCBI annotation of GRCm38

  29162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: plasma protein S
Gene Tree: Gas6

Human
homologs
Human Homolog GAS6, growth arrest-specific 6
NCBI Gene ID 2621
neXtProt AC  NX_Q14393
Human Synonyms  AXLLG, AXSF
Human Chr (Location)  13q34; chr13:113820549-113864073 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are protected against arterial and venous thrombosis, and though platelet aggregation is impaired, spontaneous or excess trauma-induced bleeding is not observed.
 
Interactions
Gas6 interacts with 33 markers (Mir103-1, Mir186, Mir190b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process activation of protein kinase B activity, apoptotic cell clearance, ...
Component cytoplasm, extracellular region, ...
Function binding, bridging, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (247)    Tissues (65)    Images (56)
Theiler Stages: 1, 2, 3, 4, 17, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 238
RT-PCR 9
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031451 (Evidence)
Entrez Gene14456 (Evidence)
UniGene3982
DFCITC1575666
DoTSDT.532106
NIA Mouse Gene IndexU029601
Consensus CDS ProjectCCDS40232.1
International Mouse Knockout Project StatusGas6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14456 NCBI Gene Model | MGI Sequence Detail 29162 C57BL/6J ±  kb
transcript NM_019521 RefSeq | MGI Sequence Detail 2594 C57BL/6 
polypeptide Q61592 UniProt | EBI | MGI Sequence Detail 674 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000007853 growth arrest-specific protein 6
Graphical View of Protein Domain Structure
References (Earliest) J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
(Latest) J:199029 Akitake-Kawano R, et al., Inhibitory role of Gas6 in intestinal tumorigenesis. Carcinogenesis. 2013 Jul;34(7):1567-74
All references(69)
Other
accession IDs
MGD-MRK-9991, MGD-MRK-9997

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory