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Gas6 Gene Detail
Summary
  • Symbol
    Gas6
  • Name
    growth arrest specific 6
  • Synonyms
    Gas-6, GAS 6, growth arrest-specific
  • Feature Type
    protein coding gene
  • IDs
    MGI:95660
    NCBI Gene: 14456
  • Gene Overview
    MyGene.info: GAS6
Location & Maps
more
  • Sequence Map
    Chr8:13465374-13494535 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29162 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GAS6, growth arrest specific 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GAS6, growth arrest specific 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AXLLG, AXSF
  • Links
    NCBI Gene ID: 2621
    neXtProt AC: NX_Q14393

  • Chr Location
    13q34; chr13:113820549-113864103 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice are protected against arterial and venous thrombosis, and though platelet aggregation is impaired, spontaneous or excess trauma-induced bleeding is not observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14456 NCBI Gene Model | MGI Sequence Detail 29162 C57BL/6J ±  kb
transcript NM_019521 RefSeq | MGI Sequence Detail 2594 C57BL/6  
polypeptide Q61592 UniProt | EBI | MGI Sequence Detail 674 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    295 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007853 growth arrest-specific protein 6
  • InterPro Domains
    IPR017857 Coagulation factor, subgroup, Gla domain
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR001791 Laminin G domain
Molecular
Reagents
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  • All nucleic 151
    cDNA 150
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9991, MGD-MRK-9997
References
more
  • Summaries
    All 68
    Developmental Gene Expression 8
    Gene Ontology 13
    Phenotypes 24
  • Earliest
    J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
  • Latest
    J:220148 Salian-Mehta S, et al., Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):164-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory