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Gart Gene Detail
Summary
  • Symbol
    Gart
  • Name
    phosphoribosylglycinamide formyltransferase
  • Synonyms
    Gaps, Prgs
  • Feature Type
    protein coding gene
  • IDs
    MGI:95654
    NCBI Gene: 14450
Location & Maps
more
  • Sequence Map
    Chr16:91621186-91646952 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.18 cM, cytoband C3-C4
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIRS, GARS, GARTF, PAIS, PGFT, PRGS
  • Links
    NCBI Gene ID: 2618
    neXtProt AC: NX_P22102

  • Chr Location
    21q22.11; chr21:33503931-33542917 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 637
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;2 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: GART
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    108
  • Gene trapped
    96
  • Targeted
    10
  • Transgenic
    2
  • Genomic Mutations
    6 involving Gart
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028333 VEGA Gene Model | MGI Sequence Detail 25767 C57BL/6J ±  kb
transcript OTTMUST00000070222 VEGA | MGI Sequence Detail 3518 Not Applicable  
polypeptide OTTMUSP00000035755 VEGA | MGI Sequence Detail 1010 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    90 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR010918 AIR synthase-related protein, C-terminal domain
    IPR011761 ATP-grasp fold
    IPR013815 ATP-grasp fold, subdomain 1
    IPR013816 ATP-grasp fold, subdomain 2
    IPR002376 Formyl transferase, N-terminal
    IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase
    IPR004607 Phosphoribosylglycinamide formyltransferase
    IPR001555 Phosphoribosylglycinamide formyltransferase, active site
    IPR000115 Phosphoribosylglycinamide synthetase
    IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    IPR020560 Phosphoribosylglycinamide synthetase, C-domain
    IPR020559 Phosphoribosylglycinamide synthetase, conserved site
    IPR020562 Phosphoribosylglycinamide synthetase, N-terminal
    IPR016185 Pre-ATP-grasp domain
    IPR016188 PurM-like, N-terminal domain
    IPR011054 Rudiment single hybrid motif
Molecular
Reagents
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  • All nucleic 270
    Genomic 12
    cDNA 255
    Primer pair 1
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13607, MGD-MRK-9982, MGD-MRK-9984
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:12144 Cox DR, et al., Chromosomal assignment of mouse PRGS: further evidence for homology between mouse chromosome 16 and human chromosome 21. Am J Hum Genet. 1981;33:145A (Abstr.)
  • Latest
    J:180201 Liu C, et al., Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 2011 Nov;130(5):623-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory