About   Help   FAQ
Gart Gene Detail
Summary
  • Symbol
    Gart
  • Name
    phosphoribosylglycinamide formyltransferase
  • Synonyms
    Gaps, Prgs
  • Feature Type
    protein coding gene
  • IDs
    MGI:95654
    NCBI Gene: 14450
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91621186-91646952 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.18 cM, cytoband C3-C4
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95654
protein coding gene Chr16:91621186-91647198 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023045
protein coding gene Chr16:92649228-92674730 (-)
A/J MGP_AJ_G0023013
protein coding gene Chr16:88314175-88340278 (-)
AKR/J MGP_AKRJ_G0022983
protein coding gene Chr16:90984640-91010038 (-)
BALB/cJ MGP_BALBcJ_G0023015
protein coding gene Chr16:88841184-88867490 (-)
C3H/HeJ MGP_C3HHeJ_G0022776
protein coding gene Chr16:91558702-91585083 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023462
protein coding gene Chr16:95639415-95668166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020964
protein coding gene Chr16:86010954-86037636 (-)
CAST/EiJ MGP_CASTEiJ_G0022295
protein coding gene Chr16:92120819-92147766 (-)
CBA/J MGP_CBAJ_G0022745
protein coding gene Chr16:99723798-99757123 (-)
DBA/2J MGP_DBA2J_G0022879
protein coding gene Chr16:88218411-88244330 (-)
FVB/NJ MGP_FVBNJ_G0022853
protein coding gene Chr16:87343676-87369209 (-)
LP/J MGP_LPJ_G0022949
protein coding gene Chr16:92349531-92374830 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022874
protein coding gene Chr16:104269710-104298984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023480
protein coding gene Chr16:91504735-91530123 (-)
PWK/PhJ MGP_PWKPhJ_G0022040
protein coding gene Chr16:88395793-88422656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021870
protein coding gene Chr16:91063813-91090740 (-)
WSB/EiJ MGP_WSBEiJ_G0022347
protein coding gene Chr16:91744194-91774127 (-)



Homology
more
  • Human Ortholog
    GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIRS, GARS, GARTF, PAIS, PGFT, PRGS
  • Links
    NCBI Gene ID: 2618
    neXtProt AC: NX_P22102
    UniProt: P22102

  • Chr Location
    21q22.11; chr21:33503931-33542917 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 637
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;2 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GART
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022962 Ensembl Gene Model | MGI Sequence Detail 25767 C57BL/6J ±  kb
    transcript ENSMUST00000023684 Ensembl | MGI Sequence Detail 3518 Not Applicable  
    polypeptide ENSMUSP00000023684 Ensembl | MGI Sequence Detail 1010 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007847 trifunctional purine biosynthetic protein adenosine-3
    • EC
    • InterPro Domains
      IPR011761 ATP-grasp fold
      IPR013815 ATP-grasp fold, subdomain 1
      IPR002376 Formyl transferase, N-terminal
      IPR036477 Formyl transferase, N-terminal domain superfamily
      IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase
      IPR004607 Phosphoribosylglycinamide formyltransferase
      IPR001555 Phosphoribosylglycinamide formyltransferase, active site
      IPR000115 Phosphoribosylglycinamide synthetase
      IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      IPR020560 Phosphoribosylglycinamide synthetase, C-domain
      IPR037123 Phosphoribosylglycinamide synthetase, C-domain superfamily
      IPR020559 Phosphoribosylglycinamide synthetase, conserved site
      IPR020562 Phosphoribosylglycinamide synthetase, N-terminal
      IPR016185 Pre-ATP-grasp domain superfamily
      IPR010918 PurM-like, C-terminal domain
      IPR036676 PurM-like, C-terminal domain superfamily
      IPR016188 PurM-like, N-terminal domain
      IPR036921 PurM-like, N-terminal domain superfamily
      IPR011054 Rudiment single hybrid motif
    Molecular
    Reagents
    less
    • All nucleic 273
      Genomic 12
      cDNA 257
      Primer pair 1
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13607, MGD-MRK-9982, MGD-MRK-9984
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:12144 Cox DR, et al., Chromosomal assignment of mouse PRGS: further evidence for homology between mouse chromosome 16 and human chromosome 21. Am J Hum Genet. 1981;33:145A (Abstr.)
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory