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Gap43
Gene Detail
Symbol

Name
ID
Gap43
growth associated protein 43
MGI:95639
Synonyms
B-50, Basp2, GAP-43, neuromodulin
Feature Type
protein coding gene
Genetic Map
Chromosome 16
28.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr16:42248442-42340651 bp, - strand
From VEGA annotation of GRCm38

  92210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Gap43

Human
homologs
Human Homolog GAP43, growth associated protein 43
NCBI Gene ID 2596
neXtProt AC  NX_P17677
Human Synonyms  B-50, PP46
Human Chr (Location)  3q13.31; chr3:115623304-115721487 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(28) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality, abnormal optic nerve innervation, and decreased body weight.
 
Interactions
Gap43 interacts with 207 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process axon choice point recognition, axon guidance, ...
Component axon, cell junction, ...
Function calmodulin binding
External Resources: FuncBase
Expression
Literature Summary: (142 records)
Data Summary: Results (252)    Tissues (78)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 37
RNA in situ 198
Western blot 6
RT-PCR 11
cDNA source data(88)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(92) Primer pair(2) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016275 (Evidence)
Ensembl Gene ModelENSMUSG00000047261 (Evidence)
Entrez Gene14432 (Evidence)
UniGene1222
DFCITC1574594
DoTSDT.101392035, DT.94307510
NIA Mouse Gene IndexU037046
PDB4E53
Consensus CDS ProjectCCDS28177.1
International Mouse Knockout Project StatusGap43
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016275 VEGA Gene Model | MGI Sequence Detail 92210 C57BL/6J ±  kb
transcript OTTMUST00000039045 VEGA | MGI Sequence Detail 1420 Not Applicable 
polypeptide OTTMUSP00000017444 VEGA | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(8) : SNPs within 2kb(388 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001422 Neuromodulin (GAP-43)
InterPro IPR017454 Neuromodulin (GAP-43), C-terminal
InterPro IPR018947 Neuromodulin gap junction N-terminal
InterPro IPR018243 Neuromodulin, palmitoylation/phosphorylation site
Protein Ontology PR:000007839 neuromodulin
References
(Earliest) J:8666 Reeves RH, et al., Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44(2-3):76-81
(Latest) J:206879 Huang T, et al., BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20
All references(241)
Other
accession IDs
MGD-MRK-9966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory