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Gap43
Gene Detail
Symbol

Name
ID
Gap43
growth associated protein 43
MGI:95639
Synonyms
B-50, Basp2, GAP-43, neuromodulin
Feature Type
protein coding gene
Genetic Map
Chromosome 16
28.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr16:42248442-42340651 bp, - strand
From VEGA annotation of GRCm38

  92210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GAP43
Gene Tree: Gap43

Human
homologs
GAP43, growth associated protein 43
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2596
neXtProt AC: NX_P17677

Human Synonyms: B-50, PP46

Human Chr (Location): 3q13.31; chr3:115623304-115721487 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(33) : Gene trapped(28) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality, abnormal optic nerve innervation, and decreased body weight.
 
Interactions
Gap43 interacts with 207 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process axon choice point recognition, axon guidance, ...
Component axon, cell junction, ...
Function calmodulin binding, lysophosphatidic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (146 records)
Data Summary: Results (251)    Tissues (77)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 37
RNA in situ 197
Western blot 6
RT-PCR 11
cDNA source data(88)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gap43 ; ZFIN gap43    NEW 
Molecular
reagents
All nucleic(97) cDNA(92) Primer pair(2) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016275 (Evidence)
Ensembl Gene Model ENSMUSG00000047261 (Evidence)
Entrez Gene 14432 (Evidence)
UniGene 1222
DFCI TC1574594
DoTS DT.101392035, DT.94307510
NIA Mouse Gene Index U037046
PDB 4E53
Consensus CDS Project CCDS28177.1
International Mouse Phenotyping Consortium Status Gap43
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016275 VEGA Gene Model | MGI Sequence Detail 92210 C57BL/6J ±  kb
transcript OTTMUST00000039045 VEGA | MGI Sequence Detail 1420 Not Applicable 
polypeptide OTTMUSP00000017444 VEGA | MGI Sequence Detail 227 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(8) : SNPs within 2kb(388 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001422 Neuromodulin (GAP-43)
InterPro IPR017454 Neuromodulin (GAP-43), C-terminal
InterPro IPR018947 Neuromodulin gap junction N-terminal
InterPro IPR018243 Neuromodulin, palmitoylation/phosphorylation site
Protein Ontology PR:000007839 neuromodulin
References
(Earliest) J:8666 Reeves RH, et al., Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44(2-3):76-81
(Latest) J:217856 Corradini I, et al., Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs. Cereb Cortex. 2014 Feb;24(2):364-76
All references(244)
Other
accession IDs
MGD-MRK-9966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory