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Gap43 Gene Detail
Summary
  • Symbol
    Gap43
  • Name
    growth associated protein 43
  • Synonyms
    B-50, Basp2, GAP-43, neuromodulin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95639
    NCBI Gene: 14432
  • Gene Overview
    MyGene.info: GAP43
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:42248552-42340651 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.37 cM
  • Mapping Data
    34 experiments
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95639
protein coding gene Chr16:42248442-42340651 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022826
protein coding gene Chr16:40924108-41021468 (-)
A/J MGP_AJ_G0022791
protein coding gene Chr16:39018107-39112298 (-)
AKR/J MGP_AKRJ_G0022763
protein coding gene Chr16:40345597-40443493 (-)
BALB/cJ MGP_BALBcJ_G0022792
protein coding gene Chr16:39029744-39123644 (-)
C3H/HeJ MGP_C3HHeJ_G0022556
protein coding gene Chr16:40495842-40599145 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023239
protein coding gene Chr16:41864766-41965158 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020754
protein coding gene Chr16:39183748-39272358 (-)
CAST/EiJ MGP_CASTEiJ_G0022082
protein coding gene Chr16:40697873-40797768 (-)
CBA/J MGP_CBAJ_G0022527
protein coding gene Chr16:43657295-43761527 (-)
DBA/2J MGP_DBA2J_G0022659
protein coding gene Chr16:38787517-38884394 (-)
FVB/NJ MGP_FVBNJ_G0022634
protein coding gene Chr16:38772154-38865022 (-)
LP/J MGP_LPJ_G0022727
protein coding gene Chr16:40615052-40712679 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022653
protein coding gene Chr16:42988022-43083871 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023254
protein coding gene Chr16:40330898-40429071 (-)
PWK/PhJ MGP_PWKPhJ_G0021822
protein coding gene Chr16:39193004-39287777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021653
protein coding gene Chr16:40256241-40361093 (-)
WSB/EiJ MGP_WSBEiJ_G0022126
protein coding gene Chr16:40437648-40534387 (-)



Homology
more
  • Human Ortholog
    GAP43, growth associated protein 43
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GAP43, growth associated protein 43
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B-50, PP46
  • Links
    NCBI Gene ID: 2596
    neXtProt AC: NX_P17677
    UniProt: P17677

  • Chr Location
    3q13.31; chr3:115623304-115721487 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1545
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GAP43
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, abnormal optic nerve innervation, and decreased body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14432 NCBI Gene Model | MGI Sequence Detail 92100 C57BL/6J ±  kb
    transcript NM_008083 RefSeq | MGI Sequence Detail 1316 Not Specified  
    polypeptide P06837 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 94
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9966
    References
    more
    • Summaries
      All 280
      Developmental Gene Expression 168
      Gene Ontology 16
      Phenotypes 37
    • Earliest
      J:8666 Reeves RH, et al., Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44(2-3):76-81
    • Latest
      J:269990 Chen Z, et al., Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway. Cancer Discov. 2019 Jan;9(1):114-129

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory