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Gal Gene Detail
Summary
  • Symbol
    Gal
  • Name
    galanin
  • Synonyms
    Galn
  • Feature Type
    protein coding gene
  • IDs
    MGI:95637
    NCBI Gene: 14419
  • Gene Overview
    MyGene.info: GAL
Location & Maps
more
  • Genetic Map
    Chromosome 19, 3.16 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    GAL, galanin and GMAP prepropeptide
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GAL, galanin and GMAP prepropeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETL8, GAL-GMAP, GALN, GLNN, GMAP
  • Links
    NCBI Gene ID: 51083
    neXtProt AC: NX_P22466

  • Chr Location
    11q13.2; chr11:68684515-68691175 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human GAL associations

Human Disease Mouse Models
       Epilepsy, Familial Temporal Lobe, 8; ETL8   OMIM: 616461
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to alterations in neuroendocrine homeostasis, prolactin release, lactotroph number, mammary gland maturation, lactation, susceptibility to neuronal excitotoxicity and induced seizures, sensory neuron developmentand regeneration, and long term potentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14419 NCBI Gene Model | MGI Sequence Detail 4541 C57BL/6J ±  kb
transcript NM_010253 RefSeq | MGI Sequence Detail 806 C57BL/6  
polypeptide P47212 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    76 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 24
    Genomic 7
    cDNA 15
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9963
References
more
  • Summaries
    All 102
    Developmental Gene Expression 27
    Gene Ontology 6
    Phenotypes 43
  • Earliest
    J:13272 Hyde JF, et al., Galanin gene expression in the hypothalamopituitary axis of the Ames Dwarf mouse. Mol Cell Neurosci. 1993 Jun;4(3):298-303
  • Latest
    J:231980 Tomas-Roca L, et al., Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features. Brain Struct Funct. 2016 Mar;221(2):815-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory