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Slc6a11 Gene Detail
Summary
  • Symbol
    Slc6a11
  • Name
    solute carrier family 6 (neurotransmitter transporter, GABA), member 11
  • Synonyms
    D930045G19Rik, E130202I16Rik, Gabt4, Gat3, GAT4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95630
    NCBI Gene: 243616
Location & Maps
more
  • Sequence Map
    Chr6:114131241-114249886 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118646 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    SLC6A11, solute carrier family 6 (neurotransmitter transporter), member 11
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC6A11, solute carrier family 6 (neurotransmitter transporter), member 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GAT3, GAT-3, GAT4
  • Links
    NCBI Gene ID: 6538
    neXtProt AC: NX_P48066

  • Chr Location
    3p25.3; chr3:10816200-10941471 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Slc6a11
  • Incidental Mutations
Mice homozygous for a targeted mutation display postnatal lethality. Mice heterozygous for a targeted mutation display resistance to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 243616 NCBI Gene Model | MGI Sequence Detail 118646 C57BL/6J ±  kb
transcript NM_172890 RefSeq | MGI Sequence Detail 4066 C57BL/6  
polypeptide P31650 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1062 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015177 sodium- and chloride-dependent GABA transporter 3
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002982 Sodium:neurotransmitter symporter, GABA, GAT-3
Molecular
Reagents
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  • All nucleic 26
    Genomic 10
    cDNA 11
    Primer pair 5

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-9950, MGI:1925977, MGI:2443874
References
more
  • Summaries
    All 39
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
  • Latest
    J:216206 Stephan J, et al., Functional analysis of the inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in astrocytes of the lateral superior olive. Glia. 2014 Dec;62(12):1992-2003

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory