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Slc6a11
Gene Detail
 Symbol
Name
ID
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
MGI:95630
Synonyms D930045G19Rik, E130202I16Rik, Gabt4, Gat3, GAT4
Feature Type protein coding gene
Genetic Map
Chromosome 6
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:114131241-114249886 bp, + strand
From NCBI annotation of GRCm38

  118646 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129935  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slc6a11

Human
homologs
Human Homolog SLC6A11, solute carrier family 6 (neurotransmitter transporter), member 11
NCBI Gene ID 6538
neXtProt AC  NX_P48066
Human Synonyms  GAT3, GAT-3, GAT4
Human Chr (Location)  3p25.3; chr3:10816232-10938460 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display postnatal lethality. Mice heterozygous for a targeted mutation display resistance to pharmacologically induced seizures.
 
Interactions
Slc6a11 interacts with 243 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process amino acid transmembrane transport, gamma-aminobutyric acid transport, ...
Component cell projection, cytoplasm, ...
Function gamma-aminobutyric acid:sodium symporter activity, neurotransmitter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (287)    Tissues (116)    Images (50)
Theiler Stages: 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 146
In situ reporter (knock in) 48
RT-PCR 93
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(10) cDNA(11) Primer pair(5)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000030307 (Evidence)
Entrez Gene243616 (Evidence)
DFCITC1583554, TC1628169
DoTSDT.55213352, DT.91337373
NIA Mouse Gene IndexU007284
Consensus CDS ProjectCCDS39597.1
International Mouse Knockout Project StatusSlc6a11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 243616 NCBI Gene Model | MGI Sequence Detail 118646 C57BL/6J ±  kb
transcript NM_172890 RefSeq | MGI Sequence Detail 4066 C57BL/6 
polypeptide P31650 UniProt | EBI | MGI Sequence Detail 627 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(1062 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002982 Sodium:neurotransmitter symporter, GABA, GAT-3
Protein Ontology PR:000015177 sodium- and chloride-dependent GABA transporter 3
Graphical View of Protein Domain Structure
References (Earliest) J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
(Latest) J:191581 Zhou Y, et al., Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem. 2012 Oct 12;287(42):35733-46
All references(40)
Other
accession IDs
MGD-MRK-9950, MGI:1925977, MGI:2443874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory