Slc6a11
Gene Detail

Symbol Name ID

Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 MGI:95630

Synonyms

D930045G19Rik, E130202I16Rik, Gabt4, Gat3, GAT4

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr6:114131241-114249886 bp, + strand From NCBI annotation of GRCm38   118646 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc6a11 ± 2 cM)

Gene Tree: Slc6a11

Human ortholog

SLC6A11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 NCBI Gene ID 6538
Human Synonyms: GAT3, GAT-3, GAT4
Human Chr3:10857917-10980146 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a targeted mutation display postnatal lethality. Mice heterozygous for a targeted mutation display resistance to pharmacologically induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	neurotransmitter transport, transport
Component	cell projection, cytoplasm, ...
Function	gamma-aminobutyric acid:sodium symporter activity, neurotransmitter binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (287)    Tissues (113)    Images (50)
Theiler Stages: 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	146
In situ reporter (knock in)	48
RT-PCR	93

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(10) cDNA(11) Primer pair(5)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000030307 (Evidence)
Entrez Gene	243616 (Evidence)
DFCI	TC1583554, TC1628169
DoTS	DT.55213352, DT.91337373
NIA Mouse Gene Index	U007284
Consensus CDS Project	CCDS39597.1
International Mouse Knockout Project Status	Slc6a11

Sequences

Length	Strain/Species
genomic	243616	NCBI Gene Model | MGI Sequence Detail	118646	C57BL/6J
transcript	NM_172890	RefSeq | MGI Sequence Detail	4066	C57BL/6
polypeptide	P31650	UniProt | EBI | MGI Sequence Detail	627	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(592 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
InterPro	IPR002982	Sodium:neurotransmitter symporter, GABA, GAT-3
Protein Ontology	PR:000015177	sodium- and chloride-dependent GABA transporter 3

Graphical View of Protein Domain Structure

References

(Earliest) J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
(Latest) J:191581 Zhou Y, et al., Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem. 2012 Oct 12;287(42):35733-46
All references(39)

Other accession IDs

MGD-MRK-9950, MGI:1925977, MGI:2443874