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Slc6a13 Gene Detail
Summary
  • Symbol
    Slc6a13
  • Name
    solute carrier family 6 (neurotransmitter transporter, GABA), member 13
  • Synonyms
    Gabt3, Gat2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95629
    NCBI Gene: 14412
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121300296-121337721 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.22 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95629
protein coding gene Chr6:121300227-121337733 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031216
protein coding gene Chr6:124245007-124283122 (+)
A/J MGP_AJ_G0031185
protein coding gene Chr6:119455254-119493097 (+)
AKR/J MGP_AKRJ_G0031116
protein coding gene Chr6:122680495-122718585 (+)
BALB/cJ MGP_BALBcJ_G0031196
protein coding gene Chr6:119223296-119261088 (+)
C3H/HeJ MGP_C3HHeJ_G0030914
protein coding gene Chr6:122708094-122747137 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031654
protein coding gene Chr6:127417230-127454795 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028814
protein coding gene Chr6:116361856-116399461 (+)
CAST/EiJ MGP_CASTEiJ_G0030303
protein coding gene Chr6:123159662-123198767 (+)
CBA/J MGP_CBAJ_G0030879
protein coding gene Chr6:132480220-132524224 (+)
DBA/2J MGP_DBA2J_G0031035
protein coding gene Chr6:118346133-118383700 (+)
FVB/NJ MGP_FVBNJ_G0030987
protein coding gene Chr6:117490917-117530303 (+)
LP/J MGP_LPJ_G0031114
protein coding gene Chr6:124234725-124272710 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031021
protein coding gene Chr6:136418856-136460603 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031683
protein coding gene Chr6:122718620-122757949 (+)
PWK/PhJ MGP_PWKPhJ_G0030018
protein coding gene Chr6:117388749-117426949 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029847
protein coding gene Chr6:121453281-121492877 (+)
WSB/EiJ MGP_WSBEiJ_G0030386
protein coding gene Chr6:123009438-123052213 (+)



Homology
more
  • Human Ortholog
    SLC6A13, solute carrier family 6 member 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC6A13, solute carrier family 6 member 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAT2, GAT-2, GAT3
  • Links
    NCBI Gene ID: 6540
    neXtProt AC: NX_Q9NSD5
    UniProt: Q9NSD5

  • Chr Location
    12p13.33; chr12:220621-262930 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced taurine levels in the liver and increased taurine levels in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14412 NCBI Gene Model | MGI Sequence Detail 37426 C57BL/6J ±  kb
transcript NM_144512 RefSeq | MGI Sequence Detail 2175 C57BL/6  
polypeptide P31649 UniProt | EBI | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015179 sodium- and chloride-dependent GABA transporter 2
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002981 Sodium:neurotransmitter symporter, GABA, GAT-2
    IPR037272 Sodium:neurotransmitter symporter superfamily
Molecular
Reagents
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  • All nucleic 51
    cDNA 48
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9949
References
more
  • Summaries
    All 42
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
  • Latest
    J:242946 Darlington TM, et al., Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016 Jun;15(5):474-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory