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Slc6a12 Gene Detail
Summary
  • Symbol
    Slc6a12
  • Name
    solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
  • Synonyms
    BGT1, Gabt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95628
    NCBI Gene: 14411
  • Alliance
    genome feature page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121320035-121342734 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.25 cM, cytoband F1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    677 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95628
 protein coding gene Chr6:121319533-121342734 (+)
129S1/SvImJ ENSMUSG00200047824
 protein coding gene Chr6:118524672-118543821 (+)
A/J ENSMUSG00195047103
 protein coding gene Chr6:117938889-117958040 (+)
AKR/J ENSMUSG00220021237
 protein coding gene Chr6:116824100-116843249 (+)
BALB/cJ ENSMUSG00180038369
 protein coding gene Chr6:118306552-118325703 (+)
C3H/HeJ ENSMUSG00175043227
 protein coding gene Chr6:117961870-117981017 (+)
C57BL/6NJ ENSMUSG00215048041
 protein coding gene Chr6:118290993-118310150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028815
 protein coding gene Chr6:116405091-116416057 (+)
CAST/EiJ ENSTCUG00005050345
 protein coding gene Chr6:118098464-118117565 (+)
CBA/J ENSMUSG00210029636
 protein coding gene Chr6:118073485-118092634 (+)
DBA/2J ENSMUSG00185047238
 protein coding gene Chr6:118729368-118748527 (+)
FVB/NJ ENSMUSG00205043610
 protein coding gene Chr6:117171273-117187182 (+)
JF1/MsJ ENSUMUG00000049070
 protein coding gene Chr6:117329936-117349063 (+)
LP/J ENSMUSG00230040854
 protein coding gene Chr6:119922054-119941205 (+)
NOD/ShiLtJ ENSMUSG00190035580
 protein coding gene Chr6:117686335-117705480 (+)
NZO/HlLtJ ENSMUSG00225047256
 protein coding gene Chr6:121814872-121834032 (+)
PWK/PhJ ENSLUMG00010046040
 protein coding gene Chr6:116663867-116682923 (+)
SPRET/EiJ ENSMSPG00010040346
 protein coding gene Chr6:119536245-119559217 (+)
WSB/EiJ ENSIUOG00005035777
 protein coding gene Chr6:118335744-118354778 (+)



Homology
more
  • Human Ortholog
    SLC6A12, solute carrier family 6 member 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A12, solute carrier family 6 member 12
  • Synonyms
    BGT-1, BGT1, GAT2
  • Links
    NCBI Gene ID: 6539
    UniProt: P48065

  • Chr Location
    12p13.33; chr12:183848-220144 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Mice homozygous for a targeted allele exhibit normal seizure threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    145
  • cDNA Data
    25
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030109 Ensembl Gene Model | MGI Sequence Detail 22700 C57BL/6J ±  kb
transcript ENSMUST00000032200 Ensembl | MGI Sequence Detail 2644 Not Applicable  
polypeptide ENSMUSP00000032200 Ensembl | MGI Sequence Detail 628 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000015178 sodium- and chloride-dependent betaine transporter
    (term hierarchy)
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002983 Sodium:neurotransmitter symporter, betaine
    IPR037272 Sodium:neurotransmitter symporter superfamily
  • GlyGen
    P31651 2 sites
Molecular
Reagents
less
  • All nucleic 28
    cDNA 25
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9948
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:2236 Lopez-Corcuera B, et al., Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter. J Biol Chem. 1992 Sep 5;267(25):17491-3
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory