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Gabrr2 Gene Detail
Summary
  • Symbol
    Gabrr2
  • Name
    gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95626
    NCBI Gene: 14409
  • Gene Overview
    MyGene.info: GABRR2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33062999-33095865 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 14.64 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95626
protein coding gene Chr4:33057712-33095865 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028118
protein coding gene Chr4:30557968-30593051 (+)
A/J MGP_AJ_G0028076
protein coding gene Chr4:29465499-29498764 (+)
AKR/J MGP_AKRJ_G0028039
protein coding gene Chr4:30232353-30264973 (+)
BALB/cJ MGP_BALBcJ_G0028087
protein coding gene Chr4:29727988-29760809 (+)
C3H/HeJ MGP_C3HHeJ_G0027816
protein coding gene Chr4:30520484-30557159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028529
protein coding gene Chr4:31753394-31794034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025870
protein coding gene Chr4:27530694-27564458 (+)
CAST/EiJ MGP_CASTEiJ_G0027271
protein coding gene Chr4:30299644-30340586 (+)
CBA/J MGP_CBAJ_G0027788
protein coding gene Chr4:32789019-32824271 (+)
DBA/2J MGP_DBA2J_G0027932
protein coding gene Chr4:29467938-29502530 (+)
FVB/NJ MGP_FVBNJ_G0027898
protein coding gene Chr4:28894847-28931545 (+)
LP/J MGP_LPJ_G0028040
protein coding gene Chr4:30648429-30684247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027931
protein coding gene Chr4:35351276-35393094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028588
protein coding gene Chr4:30242642-30281380 (+)
PWK/PhJ MGP_PWKPhJ_G0026990
protein coding gene Chr4:29472545-29508518 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026819
protein coding gene Chr4:30129838-30168920 (+)
WSB/EiJ MGP_WSBEiJ_G0027347
protein coding gene Chr4:30239685-30277824 (+)



Homology
more
  • Human Ortholog
    GABRR2, gamma-aminobutyric acid type A receptor rho2 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABRR2, gamma-aminobutyric acid type A receptor rho2 subunit
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2570
    neXtProt AC: NX_P28476
    UniProt: P28476

  • Chr Location
    6q15; chr6:89254464-89315299 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20471
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GABRR2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023267 Ensembl Gene Model | MGI Sequence Detail 32867 C57BL/6J ±  kb
    transcript ENSMUST00000024035 Ensembl | MGI Sequence Detail 1820 Not Applicable  
    polypeptide ENSMUSP00000024035 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007783 gamma-aminobutyric acid receptor subunit rho-2
    • InterPro Domains
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR008057 Gamma-aminobutyric-acid A receptor, Rho
      IPR008059 Gamma-aminobutyric-acid A receptor, Rho2
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9945
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:2295 Cutting GR, et al., Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 1992 Apr;12(4):801-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory