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Gabrr1
Gene Detail
Symbol

Name
ID
Gabrr1
gamma-aminobutyric acid (GABA) C receptor, subunit rho 1
MGI:95625
Synonyms
GABA-C
Feature Type
protein coding gene
Genetic Map
Chromosome 4
14.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:33132521-33163588 bp, + strand
From VEGA annotation of GRCm38

  31068 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20470  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GABRR1
Gene Tree: Gabrr1

Human
homologs
GABRR1, gamma-aminobutyric acid (GABA) A receptor, rho 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2569
neXtProt AC: NX_P24046

Human Chr (Location): 6q15; chr6:89177504-89231288 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display altered visual processing in the retina. Mice homozygous for a different knock-out allele exhibit alterations of mechanical pain sensitivity, GABA-inhibited spinal cord responses, and olfactory function.
 
Interactions
Gabrr1 interacts with 162 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process chloride transport, ion transport, ...
Component cell junction, chloride channel complex, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (26)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 3
RT-PCR 23
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gabrr1    NEW 
Molecular
reagents
All nucleic(6) cDNA(4) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000004921 (Evidence)
Ensembl Gene Model ENSMUSG00000028280 (Evidence)
Entrez Gene 14408 (Evidence)
UniGene 14116
DFCI TC1592546
DoTS DT.91328276
NIA Mouse Gene Index U004173
Consensus CDS Project CCDS18021.2
International Mouse Phenotyping Consortium Status Gabrr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004921 VEGA Gene Model | MGI Sequence Detail 31068 C57BL/6J ±  kb
transcript OTTMUST00000010951 VEGA | MGI Sequence Detail 2286 Not Applicable 
polypeptide OTTMUSP00000005116 VEGA | MGI Sequence Detail 480 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(18) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR008057 Gamma-aminobutyric-acid A receptor, Rho
InterPro IPR008058 Gamma-aminobutyric-acid A receptor, Rho1
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007782 gamma-aminobutyric acid receptor subunit rho-1
References
(Earliest) J:2295 Cutting GR, et al., Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 1992 Apr;12(4):801-6
(Latest) J:212189 Blednov YA, et al., GABAA receptors containing rho1 subunits contribute to in vivo effects of ethanol in mice. PLoS One. 2014;9(1):e85525
All references(40)
Other
accession IDs
MGD-MRK-9944

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory