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Gabrr1 Gene Detail
Summary
  • Symbol
    Gabrr1
  • Name
    gamma-aminobutyric acid (GABA) C receptor, subunit rho 1
  • Synonyms
    GABA-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:95625
    NCBI Gene: 14408
Location & Maps
more
  • Sequence Map
    Chr4:33132521-33163588 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31068 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GABRR1, gamma-aminobutyric acid (GABA) A receptor, rho 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABRR1, gamma-aminobutyric acid (GABA) A receptor, rho 1
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2569
    neXtProt AC: NX_P24046

  • Chr Location
    6q15; chr6:89177504-89231288 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically and radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Gabrr1
  • Incidental Mutations
Mice homozygous for a knock-out allele display altered visual processing in the retina. Mice homozygous for a different knock-out allele exhibit alterations of mechanical pain sensitivity, GABA-inhibited spinal cord responses, and olfactory function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004921 VEGA Gene Model | MGI Sequence Detail 31068 C57BL/6J ±  kb
transcript OTTMUST00000010951 VEGA | MGI Sequence Detail 2286 Not Applicable  
polypeptide OTTMUSP00000005116 VEGA | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    295 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007782 gamma-aminobutyric acid receptor subunit rho-1
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008057 Gamma-aminobutyric-acid A receptor, Rho
    IPR008058 Gamma-aminobutyric-acid A receptor, Rho1
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9944
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:2295 Cutting GR, et al., Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 1992 Apr;12(4):801-6
  • Latest
    J:212189 Blednov YA, et al., GABAA receptors containing rho1 subunits contribute to in vivo effects of ethanol in mice. PLoS One. 2014;9(1):e85525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory