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Gabrg3 Gene Detail
Summary
  • Symbol
    Gabrg3
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3
  • Synonyms
    B230362M20Rik, Gabrg-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95624
    NCBI Gene: 14407
  • Gene Overview
    MyGene.info: GABRG3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:56716465-57387188 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 33.48 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6584 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95624
protein coding gene Chr7:56716465-57387217 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032318
protein coding gene Chr7:57521048-58204710 (-)
A/J MGP_AJ_G0032297
protein coding gene Chr7:56654316-57322742 (-)
AKR/J MGP_AKRJ_G0032233
protein coding gene Chr7:57955917-58649756 (-)
BALB/cJ MGP_BALBcJ_G0032309
protein coding gene Chr7:56255681-56908735 (-)
C3H/HeJ MGP_C3HHeJ_G0032022
protein coding gene Chr7:58298529-58996404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032802
protein coding gene Chr7:60120850-60838880 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029809
protein coding gene Chr7:59274920-59893967 (-)
CAST/EiJ MGP_CASTEiJ_G0031351
protein coding gene Chr7:49518274-50172430 (-)
CBA/J MGP_CBAJ_G0031987
protein coding gene Chr7:62218546-62942435 (-)
DBA/2J MGP_DBA2J_G0032144
protein coding gene Chr7:55678507-56318037 (-)
FVB/NJ MGP_FVBNJ_G0032098
protein coding gene Chr7:55604649-56260534 (-)
LP/J MGP_LPJ_G0032225
protein coding gene Chr7:58603501-59315949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032135
protein coding gene Chr7:61742112-62527517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032819
protein coding gene Chr7:56969601-57648293 (-)
PWK/PhJ MGP_PWKPhJ_G0031071
protein coding gene Chr7:48918396-49535507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030912
protein coding gene Chr7:44987561-45688677 (-)
WSB/EiJ MGP_WSBEiJ_G0031469
protein coding gene Chr7:57591611-58253643 (-)



Homology
more
  • Human Ortholog
    GABRG3, gamma-aminobutyric acid type A receptor gamma3 subunit
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GABRG3, gamma-aminobutyric acid type A receptor gamma3 subunit
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2567
    neXtProt AC: NX_Q99928
    UniProt: Q99928

  • Chr Location
    15q12; chr15:26971282-27537112 (+)  GRCh38.p7

Human Diseases
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  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055026 Ensembl Gene Model | MGI Sequence Detail 670724 C57BL/6J ±  kb
transcript ENSMUST00000068911 Ensembl | MGI Sequence Detail 9767 Not Applicable  
polypeptide ENSMUSP00000067632 Ensembl | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007779 gamma-aminobutyric acid receptor subunit gamma-3
  • InterPro Domains
    IPR005440 Gamma-aminobutyric-acid A receptor, gamma 3 subunit
    IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-9941, MGD-MRK-9943, MGI:2444828
References
more
  • Summaries
    All 82
    Developmental Gene Expression 4
    Diseases 4
    Gene Ontology 7
    Phenotypes 47
  • Earliest
    J:263492 Sulpizio A, et al., Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Life Sci. 1978 Apr 24;22(16):1439-46
  • Latest
    J:260252 Nakai N, et al., Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice. Sci Adv. 2017 Jun;3(6):e1603001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory