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Gabrg2 Gene Detail
Summary
  • Symbol
    Gabrg2
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
  • Synonyms
    GABAA-R, Gabrg-2, gamma2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95623
    NCBI Gene: 14406
  • Gene Overview
    MyGene.info: GABRG2
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:41910190-42000840 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 24.80 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    563 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95623
 protein coding gene Chr11:41910190-42000857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018165
 protein coding gene Chr11:40579228-40674910 (-)
A/J MGP_AJ_G0018137
 protein coding gene Chr11:39037354-39133455 (-)
AKR/J MGP_AKRJ_G0018101
 protein coding gene Chr11:40173893-40267556 (-)
BALB/cJ MGP_BALBcJ_G0018106
 protein coding gene Chr11:39225364-39316168 (-)
C3H/HeJ MGP_C3HHeJ_G0017919
 protein coding gene Chr11:40209702-40309005 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018560
 protein coding gene Chr11:41851972-41951101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016215
 protein coding gene Chr11:37200723-37292269 (-)
CAST/EiJ MGP_CASTEiJ_G0017483
 protein coding gene Chr11:40223448-40326852 (-)
CBA/J MGP_CBAJ_G0017892
 protein coding gene Chr11:43737829-43848764 (-)
DBA/2J MGP_DBA2J_G0018002
 protein coding gene Chr11:38809221-38900020 (-)
FVB/NJ MGP_FVBNJ_G0017996
 protein coding gene Chr11:38566225-38656826 (-)
LP/J MGP_LPJ_G0018074
 protein coding gene Chr11:40809012-40911694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018020
 protein coding gene Chr11:45216443-45346075 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018599
 protein coding gene Chr11:40289808-40384497 (-)
PWK/PhJ MGP_PWKPhJ_G0017264
 protein coding gene Chr11:38828495-38924498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017056
 protein coding gene Chr11:40082638-40173709 (-)
WSB/EiJ MGP_WSBEiJ_G0017532
 protein coding gene Chr11:39967330-40065572 (-)



Homology
more
  • Human Ortholog
    GABRG2, gamma-aminobutyric acid type A receptor gamma2 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABRG2, gamma-aminobutyric acid type A receptor gamma2 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAE2, ECA2, GEFSP3
  • Links
    NCBI Gene ID: 2566
    neXtProt AC: NX_P18507
    UniProt: P18507

  • Chr Location
    5q34; chr5:162067642-162155539 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 22443
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GABRG2
  • Gene Tree
    Gabrg2
Human Diseases
more
  • Diseases
    2 with human GABRG2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 11 alleles in 14 genetic backgrounds
    1 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit retarded postnatal growth, impaired sensorimotor function, and greatly reduced lifespan. Heterozygotes show enhanced anxiety-related behaviors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    90
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    293
  • Tissues
    58
  • cDNA Data
    40
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14406 NCBI Gene Model | MGI Sequence Detail 90651 C57BL/6J ±  kb
    transcript NM_008073 RefSeq | MGI Sequence Detail 4078 C57BL/6  
    polypeptide P22723 UniProt | EBI | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007778 gamma-aminobutyric acid receptor subunit gamma-2
      (term hierarchy)
    • InterPro Domains
      IPR005439 Gamma-aminobutyric-acid A receptor, gamma 2 subunit
      IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 1
      cDNA 42
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9940, MGD-MRK-9942, MGI:2144307, MGI:2144603
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 21
      Gene Ontology 12
      Phenotypes 63
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266486 Weyn-Vanhentenryck SM, et al., Precise temporal regulation of alternative splicing during neural development. Nat Commun. 2018 Jun 6;9(1):2189
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Send questions and comments to User Support.     		last database update
    01/08/2019
    MGI 6.13     		The Jackson Laboratory