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Gabrg2
Gene Detail
 Symbol
Name
ID
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
MGI:95623
Synonyms GABAA-R, Gabrg-2, gamma2
Feature Type protein coding gene
Genetic Map
Chromosome 11
24.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:41910203-42000857 bp, - strand
From VEGA annotation of GRCm38

  90655 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gabrg2

Human
homologs
Human Homolog GABRG2, gamma-aminobutyric acid (GABA) A receptor, gamma 2
NCBI Gene ID 2566
neXtProt AC  NX_P18507
Human Synonyms  CAE2, ECA2, GEFSP3
Human Chr (Location)  5q34; chr5:162067642-162155539 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GABRG2
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(1) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit retarded postnatal growth, impaired sensorimotor function, and greatly reduced lifespan. Heterozygotes show enhanced anxiety-related behaviors.
 
Interactions
Gabrg2 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process adult behavior, cellular response to histamine, ...
Component axon, cell junction, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (284)    Tissues (54)    Images (60)
Theiler Stages: 19, 22, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 273
RT-PCR 11
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(39) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006345 (Evidence)
Ensembl Gene ModelENSMUSG00000020436 (Evidence)
Entrez Gene14406 (Evidence)
UniGene5309
DFCITC1577142, TC1589952, TC1590499, TC1635921
DoTSDT.101346459, DT.484764, DT.91280316, DT.97357474
NIA Mouse Gene IndexU032671
Consensus CDS ProjectCCDS24551.1, CCDS24552.2
International Mouse Knockout Project StatusGabrg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006345 VEGA Gene Model | MGI Sequence Detail 90655 C57BL/6J ±  kb
transcript OTTMUST00000014428 VEGA | MGI Sequence Detail 2234 Not Applicable 
polypeptide OTTMUSP00000065449 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(8) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(568 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR005439 Gamma-aminobutyric-acid A receptor, gamma 2 subunit
InterPro IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007778 gamma-aminobutyric acid receptor subunit gamma-2
References (Earliest) J:10726 Shivers BD, et al., Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 1989 Sep;3(3):327-37
(Latest) J:211348 Clopath C, et al., A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. J Neurosci. 2014 May 21;34(21):7203-15
All references(111)
Other
accession IDs
MGD-MRK-9940, MGD-MRK-9942, MGI:2144307, MGI:2144603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory