Gabrg2
Gene Detail

Symbol Name ID

Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 MGI:95623

Synonyms

GABAA-R, Gabrg-2, gamma2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

24.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr11:41910203-42000857 bp, - strand From VEGA annotation of GRCm38   90655 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gabrg2

Human homologs

Human Homolog		GABRG2, gamma-aminobutyric acid (GABA) A receptor, gamma 2
NCBI Gene ID		2566
neXtProt AC		NX_P18507
Human Synonyms		CAE2, ECA2, GEFSP3
Human Chr (Location)		5q34; chr5:161494648-161582545 (+)  GRCh37.p13
Disease Associations		(2) Diseases Associated with Human GABRG2

Alleles and phenotypes

All alleles(14) : Targeted(13) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit retarded postnatal growth, impaired sensorimotor function, and greatly reduced lifespan. Heterozygotes show enhanced anxiety-related behaviors.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	adult behavior, chloride transmembrane transport, ...
Component	axon, cell junction, ...
Function	chloride channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)

Data Summary: Results (284)    Tissues (53)    Images (60)
Theiler Stages: 19, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	273
RT-PCR	11

cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(39) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006345 (Evidence)
Ensembl Gene Model	ENSMUSG00000020436 (Evidence)
Entrez Gene	14406 (Evidence)
UniGene	5309
DFCI	TC1577142, TC1589952, TC1590499, TC1635921
DoTS	DT.101346459, DT.484764, DT.91280316, DT.97357474
NIA Mouse Gene Index	U032671
Consensus CDS Project	CCDS24551.1, CCDS24552.1
International Mouse Knockout Project Status	Gabrg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006345	VEGA Gene Model | MGI Sequence Detail	90655	C57BL/6J
transcript	OTTMUST00000014428	VEGA | MGI Sequence Detail	2234	Not Applicable
polypeptide	OTTMUSP00000065449	VEGA | MGI Sequence Detail	474	Not Applicable

All sequences(83) RefSeq(8) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(568 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR005439	Gamma-aminobutyric-acid A receptor, gamma 2 subunit
InterPro	IPR005437	Gamma-aminobutyric-acid A receptor, gamma subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007778	gamma-aminobutyric acid receptor subunit gamma-2

References

(Earliest) J:10726 Shivers BD, et al., Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 1989 Sep;3(3):327-37
(Latest) J:203975 Vargas E, et al., Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility. J Physiol. 2013 Jan 1;591(Pt 1):57-65
All references(108)

Other accession IDs

MGD-MRK-9940, MGD-MRK-9942, MGI:2144307, MGI:2144603