Gabrd
Gene Detail

Symbol Name ID

Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta MGI:95622

Feature Type

protein coding gene

Genetic Map

Chromosome 4

86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:155384980-155398112 bp, - strand From VEGA annotation of GRCm38   13133 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gabrd

Human homologs

Human Homolog		GABRD, gamma-aminobutyric acid (GABA) A receptor, delta
NCBI Gene ID		2563
neXtProt AC		NX_O14764
Human Synonyms		EIG10, EJM7, GEFSP5
Human Chr (Location)		1p36.3; chr1:1950768-1962192 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GABRD

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele exhibit increased postpartum depression and anxiety behaviors, lethality of pups due to materal neglect, and increased cued and contextual conditional freezing.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	chloride transport, ion transport, ...
Component	cell junction, chloride channel complex, ...
Function	chloride channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (253)    Tissues (41)    Images (26)
Theiler Stages: 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	244
RT-PCR	9

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(4) cDNA(9) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000010612 (Evidence)
Ensembl Gene Model	ENSMUSG00000029054 (Evidence)
Entrez Gene	14403 (Evidence)
UniGene	388925
DFCI	TC1582932, TC1655103, TC1733886
NIA Mouse Gene Index	U025869
Consensus CDS Project	CCDS19028.1
International Mouse Knockout Project Status	Gabrd

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010612	VEGA Gene Model | MGI Sequence Detail	13133	C57BL/6J
transcript	OTTMUST00000024803	VEGA | MGI Sequence Detail	1921	Not Applicable
polypeptide	OTTMUSP00000011385	VEGA | MGI Sequence Detail	449	Not Applicable

All sequences(31) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR008098	Gamma-aminobutyric-acid A receptor delta subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007775	gamma-aminobutyric acid receptor subunit delta

References

(Earliest) J:10726 Shivers BD, et al., Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 1989 Sep;3(3):327-37
(Latest) J:188413 Absalom N, et al., alpha4betadelta GABA(A) receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13404-9
All references(69)

Other accession IDs

MGD-MRK-9939, MGI:2140393