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Gabrd
Gene Detail
Symbol

Name
ID
Gabrd
gamma-aminobutyric acid (GABA) A receptor, subunit delta
MGI:95622
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:155384980-155398112 bp, - strand
From VEGA annotation of GRCm38

  13133 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GABRD
Gene Tree: Gabrd

Human
homologs
GABRD, gamma-aminobutyric acid (GABA) A receptor, delta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2563
neXtProt AC: NX_O14764

Human Synonyms: EIG10, EJM7, GEFSP5

Human Chr (Location): 1p36.3; chr1:2019329-2030753 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GABRD

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased postpartum depression and anxiety behaviors, lethality of pups due to materal neglect, and increased cued and contextual conditional freezing.
 
Interactions
Gabrd interacts with 60 markers (Mir26a-2, Mir26b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chloride transport, ion transport, ...
Component cell junction, chloride channel complex, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (253)    Tissues (42)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
RT-PCR 9
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gabrd    NEW 
Molecular
reagents
All nucleic(14) Genomic(4) cDNA(9) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000010612 (Evidence)
Ensembl Gene Model ENSMUSG00000029054 (Evidence)
Entrez Gene 14403 (Evidence)
UniGene 388925
DFCI TC1582932, TC1655103, TC1733886
NIA Mouse Gene Index U025869
Consensus CDS Project CCDS19028.1
International Mouse Phenotyping Consortium Status Gabrd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010612 VEGA Gene Model | MGI Sequence Detail 13133 C57BL/6J ±  kb
transcript OTTMUST00000024803 VEGA | MGI Sequence Detail 1921 Not Applicable 
polypeptide OTTMUSP00000011385 VEGA | MGI Sequence Detail 449 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR008098 Gamma-aminobutyric-acid A receptor delta subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007775 gamma-aminobutyric acid receptor subunit delta
References
(Earliest) J:10726 Shivers BD, et al., Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 1989 Sep;3(3):327-37
(Latest) J:211067 Abramian AM, et al., Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7132-7
All references(76)
Other
accession IDs
MGD-MRK-9939, MGI:2140393

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory