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Gabrb2
Gene Detail
 Symbol
Name
ID
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
MGI:95620
Synonyms C030002O17Rik, C030021G16Rik, Gabrb-2
Feature Type protein coding gene
Genetic Map
Chromosome 11
25.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:42419757-42629028 bp, + strand
From VEGA annotation of GRCm38

  209272 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gabrb2

Human
homologs
Human Homolog GABRB2, gamma-aminobutyric acid (GABA) A receptor, beta 2
NCBI Gene ID 2561
neXtProt AC  NX_P47870
Human Chr (Location)  5q34; chr5:161288429-161548124 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show hyperactivity and abnormal GABA-mediated receptor currents. Homozygotes for a derivative of this allele show a sexually dimorphic cochlear phenotype associated with OHC dysfunction. Homozygotes for a knock-in allele show altered behavioral response to etomidate.
 
Interactions
Gabrb2 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cellular response to histamine, chloride transmembrane transport, ...
Component cell junction, chloride channel complex, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (227)    Tissues (138)    Images (43)
Theiler Stages: 19, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 207
RT-PCR 17
cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000006331 (Evidence)
Ensembl Gene ModelENSMUSG00000007653 (Evidence)
Entrez Gene14401 (Evidence)
DFCITC1579844, TC1582526, TC1597995
DoTSDT.101299072, DT.87049149, DT.94175080
NIA Mouse Gene IndexU012468
Consensus CDS ProjectCCDS24555.1
International Mouse Knockout Project StatusGabrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006331 VEGA Gene Model | MGI Sequence Detail 209272 C57BL/6J ±  kb
transcript OTTMUST00000014382 VEGA | MGI Sequence Detail 3989 Not Applicable 
polypeptide OTTMUSP00000006670 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(1665 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1667)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR002289 Gamma-aminobutyric-acid A receptor, beta subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007773 gamma-aminobutyric acid receptor subunit beta-2
References (Earliest) J:654 Wang JB, et al., Differential expression of two forms of GABAA receptor gamma 2-subunit in mice. Brain Res Bull. 1991 Nov;27(5):731-5
(Latest) J:192470 Oberlander JG, et al., Estrous cycle variations in GABA(A) receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area. Neuroscience. 2012 Dec 13;226:397-410
All references(70)
Other
accession IDs
MGD-MRK-9934, MGD-MRK-9937, MGI:1924780, MGI:1925783, MGI:2144269

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory