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Gabrb2
Gene Detail
Symbol

Name
ID
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
MGI:95620
Synonyms
C030002O17Rik, C030021G16Rik, Gabrb-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
25.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:42419757-42629028 bp, + strand
From VEGA annotation of GRCm38

  209272 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7327  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GABRB2
Gene Tree: Gabrb2

Human
homologs
GABRB2, gamma-aminobutyric acid (GABA) A receptor, beta 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2561
neXtProt AC: NX_P47870

Human Chr (Location): 5q34; chr5:161288419-161548124 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show hyperactivity and abnormal GABA-mediated receptor currents. Homozygotes for a derivative of this allele show a sexually dimorphic cochlear phenotype associated with OHC dysfunction. Homozygotes for a knock-in allele show altered behavioral response to etomidate.
 
Interactions
Gabrb2 interacts with 364 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (227)    Tissues (138)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 207
RT-PCR 17
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000006331 (Evidence)
Ensembl Gene Model ENSMUSG00000007653 (Evidence)
Entrez Gene 14401 (Evidence)
DFCI TC1579844, TC1582526, TC1597995
DoTS DT.101299072, DT.87049149, DT.94175080
NIA Mouse Gene Index U012468
Consensus CDS Project CCDS24555.1
International Mouse Phenotyping Consortium Status Gabrb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006331 VEGA Gene Model | MGI Sequence Detail 209272 C57BL/6J ±  kb
transcript OTTMUST00000131092 VEGA | MGI Sequence Detail 1539 Not Applicable 
polypeptide OTTMUSP00000070164 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1665 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1667)
Protein-related
information
ResourceIDDescription
InterPro IPR002289 Gamma-aminobutyric-acid A receptor, beta subunit
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007773 gamma-aminobutyric acid receptor subunit beta-2
References
(Earliest) J:654 Wang JB, et al., Differential expression of two forms of GABAA receptor gamma 2-subunit in mice. Brain Res Bull. 1991 Nov;27(5):731-5
(Latest) J:207429 Milenkovic I, et al., The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits alpha1, beta2, and delta along their extrasynaptic cell membrane. Neuroscience. 2013 Dec 19;254:80-96
All references(69)
Other
accession IDs
MGD-MRK-9934, MGD-MRK-9937, MGI:1924780, MGI:1925783, MGI:2144269

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory