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Gabra6 Gene Detail
Summary
  • Symbol
    Gabra6
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
  • Synonyms
    alpha6, GABA-ARalpha6, Gabra-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95618
    NCBI Gene: 14399
  • Gene Overview
    MyGene.info: GABRA6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:42306437-42321072 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 25.03 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95618
protein coding gene Chr11:42306437-42321130 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018167
protein coding gene Chr11:40997460-41017272 (-)
A/J MGP_AJ_G0018139
protein coding gene Chr11:39447445-39461946 (-)
AKR/J MGP_AKRJ_G0018103
protein coding gene Chr11:40604843-40619738 (-)
BALB/cJ MGP_BALBcJ_G0018108
protein coding gene Chr11:39629776-39646138 (-)
C3H/HeJ MGP_C3HHeJ_G0017921
protein coding gene Chr11:40637840-40652944 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018562
protein coding gene Chr11:42281784-42298438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016217
protein coding gene Chr11:37591028-37605414 (-)
CAST/EiJ MGP_CASTEiJ_G0017485
protein coding gene Chr11:40665408-40681395 (-)
CBA/J MGP_CBAJ_G0017894
protein coding gene Chr11:44218664-44238311 (-)
DBA/2J MGP_DBA2J_G0018004
protein coding gene Chr11:39230191-39245019 (-)
FVB/NJ MGP_FVBNJ_G0017998
protein coding gene Chr11:38959301-38973827 (-)
LP/J MGP_LPJ_G0018076
protein coding gene Chr11:41249042-41263559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018022
protein coding gene Chr11:45792868-45809213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018601
protein coding gene Chr11:40724906-40741132 (-)
PWK/PhJ MGP_PWKPhJ_G0017266
protein coding gene Chr11:39246720-39261619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017058
protein coding gene Chr11:40495804-40510330 (-)
WSB/EiJ MGP_WSBEiJ_G0017534
protein coding gene Chr11:40388439-40404161 (-)



Homology
more
  • Human Ortholog
    GABRA6, gamma-aminobutyric acid type A receptor alpha6 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABRA6, gamma-aminobutyric acid type A receptor alpha6 subunit
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2559
    neXtProt AC: NX_Q16445
    UniProt: Q16445

  • Chr Location
    5q34; chr5:161685652-161702592 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20220
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GABRA6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with normal cerebellar cytoarchitecture and normal responses to ethanol, pentobarbital and general anesthetics. Mice homozygous for a reporter allele are behaviorally normal and lack a cochlear phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020428 Ensembl Gene Model | MGI Sequence Detail 14636 C57BL/6J ±  kb
transcript ENSMUST00000155218 Ensembl | MGI Sequence Detail 2467 Not Applicable  
polypeptide ENSMUSP00000126114 Ensembl | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007771 gamma-aminobutyric acid receptor subunit alpha-6
  • InterPro Domains
    IPR005436 Gamma-aminobutyric-acid A receptor, alpha 6 subunit
    IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Molecular
Reagents
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  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-9926, MGD-MRK-9932
References
more
  • Summaries
    All 113
    Developmental Gene Expression 21
    Gene Ontology 6
    Phenotypes 34
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:265566 Ezra-Nevo G, et al., Cerebellar Learning Properties Are Modulated by the CRF Receptor. J Neurosci. 2018 Jul 25;38(30):6751-6765

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory