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Gabra5 Gene Detail
Summary
  • Symbol
    Gabra5
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
  • Synonyms
    A230018I05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95617
    NCBI Gene: 110886
Location & Maps
more
  • Sequence Map
    Chr7:57407690-57510009 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102320 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GABRA5, gamma-aminobutyric acid (GABA) A receptor, alpha 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GABRA5, gamma-aminobutyric acid (GABA) A receptor, alpha 5
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2558
    neXtProt AC: NX_P31644

  • Chr Location
    15q12; chr15:26866719-26949210 (+)  GRCh38.p2

Human Diseases
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  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    1
  • Radiation induced
    8
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    10 involving Gabra5
  • Incidental Mutations
Mice having disruptions in this gene display abnormalities in hearing and in ear structure. Subtle abnormalities in learning and in conditioning have also been reported.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055078 Ensembl Gene Model | MGI Sequence Detail 102320 C57BL/6J ±  kb
transcript ENSMUST00000068456 Ensembl | MGI Sequence Detail 2653 Not Applicable  
polypeptide ENSMUSP00000063276 Ensembl | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1135 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007770 gamma-aminobutyric acid receptor subunit alpha-5
  • InterPro Domains
    IPR005435 Gamma-aminobutyric-acid A receptor, alpha 5 subunit
    IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-9931, MGI:2442273
References
more
  • Summaries
    All 79
    Developmental Gene Expression 9
    Diseases 7
    Gene Ontology 9
    Phenotypes 68
  • Earliest
    J:16353 Khrestchatisky M, et al., A novel alpha subunit in rat brain GABAA receptors. Neuron. 1989 Dec;3(6):745-53
  • Latest
    J:226239 Botta P, et al., Regulating anxiety with extrasynaptic inhibition. Nat Neurosci. 2015 Oct;18(10):1493-500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory