Gabra5
Gene Detail

Symbol Name ID

Gabra5 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 MGI:95617

Synonyms

A230018I05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 7

33.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr7:57407690-57510009 bp, - strand From Ensembl annotation of GRCm38   102320 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gabra5

Human homologs

Human Homolog		GABRA5, gamma-aminobutyric acid (GABA) A receptor, alpha 5
NCBI Gene ID		2558
neXtProt AC		NX_P31644
Human Chr (Location)		15q12; chr15:27111866-27194357 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Mice having disruptions in this gene display abnormalities in hearing and in ear structure. Subtle abnormalities in learning and in conditioning have also been reported.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	associative learning, behavioral fear response, ...
Component	cell body, cell junction, ...
Function	chloride channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000055078 (Evidence)
Entrez Gene	110886 (Evidence)
UniGene	273114
DFCI	TC1580419
DoTS	DT.91335776, DT.99847687
NIA Mouse Gene Index	U028622
Consensus CDS Project	CCDS21322.1
International Mouse Knockout Project Status	Gabra5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000055078	Ensembl Gene Model | MGI Sequence Detail	102320	C57BL/6J
transcript	ENSMUST00000068456	Ensembl | MGI Sequence Detail	2653	Not Applicable
polypeptide	ENSMUSP00000063276	Ensembl | MGI Sequence Detail	463	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(648 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR005435	Gamma-aminobutyric-acid A receptor, alpha 5 subunit
InterPro	IPR001390	Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007770	gamma-aminobutyric acid receptor subunit alpha-5

References

(Earliest) J:16353 Khrestchatisky M, et al., A novel alpha subunit in rat brain GABAA receptors. Neuron. 1989 Dec;3(6):745-53
(Latest) J:190498 Telegdy G, et al., Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav Brain Res. 2012 Jul 15;233(1):232-6
All references(75)

Other accession IDs

MGD-MRK-9931, MGI:2442273