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Gabra5
Gene Detail
Symbol

Name
ID
Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
MGI:95617
Synonyms
A230018I05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
33.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr7:57407690-57510009 bp, - strand
From Ensembl annotation of GRCm38

  102320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gabra5

Human
homologs
Human Homolog GABRA5, gamma-aminobutyric acid (GABA) A receptor, alpha 5
NCBI Gene ID 2558
neXtProt AC  NX_P31644
Human Chr (Location)  15q12; chr15:26866719-26949210 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(6) Transgenic(1)
Genomic Mutations involving Gabra5 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice having disruptions in this gene display abnormalities in hearing and in ear structure. Subtle abnormalities in learning and in conditioning have also been reported.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Gabra5 interacts with 198 markers (Mir1b, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process associative learning, behavioral fear response, ...
Component cell body, cell junction, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000055078 (Evidence)
Entrez Gene110886 (Evidence)
UniGene273114
DFCITC1580419
DoTSDT.91335776, DT.99847687
NIA Mouse Gene IndexU028622
Consensus CDS ProjectCCDS21322.1
International Mouse Knockout Project StatusGabra5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055078 Ensembl Gene Model | MGI Sequence Detail 102320 C57BL/6J ±  kb
transcript ENSMUST00000068456 Ensembl | MGI Sequence Detail 2653 Not Applicable 
polypeptide ENSMUSP00000063276 Ensembl | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(1135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR005435 Gamma-aminobutyric-acid A receptor, alpha 5 subunit
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007770 gamma-aminobutyric acid receptor subunit alpha-5
References
(Earliest) J:16353 Khrestchatisky M, et al., A novel alpha subunit in rat brain GABAA receptors. Neuron. 1989 Dec;3(6):745-53
(Latest) J:200188 Bonin RP, et al., Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice. PLoS One. 2013;8(3):e58679
All references(78)
Other
accession IDs
MGD-MRK-9931, MGI:2442273

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory