Gabra4
Gene Detail

Symbol Name ID

Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 MGI:95616

Synonyms

Gabra-4

Feature Type

protein coding gene

Genetic Map

Chromosome 5

38.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr5:71569734-71658308 bp, - strand From NCBI annotation of GRCm38   88575 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gabra4

Human homologs

Human Homolog		GABRA4, gamma-aminobutyric acid (GABA) A receptor, alpha 4
NCBI Gene ID		2557
neXtProt AC		NX_P48169
Human Chr (Location)		4p12; chr4:46920917-46996424 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutation of this gene does not appear to result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	central nervous system development, chloride transport, ...
Component	cell junction, chloride channel complex, ...
Function	chloride channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (93)    Images (33)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	12
In situ reporter (knock in)	73
RT-PCR	61

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(15) Primer pair(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000029211 (Evidence)
Entrez Gene	14397 (Evidence)
UniGene	248731
DFCI	TC1581797, TC1611605, TC1672074, TC1679178
DoTS	DT.101180475, DT.101360149, DT.55135489, DT.94227715
NIA Mouse Gene Index	U026283
Consensus CDS Project	CCDS39107.1
International Mouse Knockout Project Status	Gabra4

Sequences

Length	Strain/Species
genomic	14397	NCBI Gene Model | MGI Sequence Detail	88575	C57BL/6J
transcript	NM_010251	RefSeq | MGI Sequence Detail	4123	C57BL/6
polypeptide	Q9D6F4	UniProt | EBI | MGI Sequence Detail	552	Not Applicable

All sequences(34) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(261 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR005434	Gamma-aminobutyric-acid A receptor, alpha 4 subunit
InterPro	IPR001390	Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007769	gamma-aminobutyric acid receptor subunit alpha-4

Graphical View of Protein Domain Structure

References

(Earliest) J:43551 Ymer S, et al., Sequence and expression of a novel GABAA receptor alpha subunit. FEBS Lett. 1989 Nov 20;258(1):119-22
(Latest) J:190498 Telegdy G, et al., Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav Brain Res. 2012 Jul 15;233(1):232-6
All references(59)

Other accession IDs

MGD-MRK-9925, MGD-MRK-9930