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Gabra4
Gene Detail
 Symbol
Name
ID
Gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
MGI:95616
Synonyms Gabra-4
Feature Type protein coding gene
Genetic Map
Chromosome 5
38.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr5:71569734-71658308 bp, - strand
From NCBI annotation of GRCm38

  88575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:631  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gabra4

Human
homologs
Human Homolog GABRA4, gamma-aminobutyric acid (GABA) A receptor, alpha 4
NCBI Gene ID 2557
neXtProt AC  NX_P48169
Human Chr (Location)  4p12; chr4:46918900-46994407 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene does not appear to result in a phenotype.
 
Interactions
Gabra4 interacts with 307 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process central nervous system development, chloride transport, ...
Component cell junction, chloride channel complex, ...
Function chloride channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (146)    Tissues (93)    Images (33)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 12
In situ reporter (knock in) 73
RT-PCR 61
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(15) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029211 (Evidence)
Entrez Gene14397 (Evidence)
UniGene248731
DFCITC1581797, TC1611605, TC1672074, TC1679178
DoTSDT.101180475, DT.101360149, DT.55135489, DT.94227715
NIA Mouse Gene IndexU026283
Consensus CDS ProjectCCDS39107.1
International Mouse Knockout Project StatusGabra4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14397 NCBI Gene Model | MGI Sequence Detail 88575 C57BL/6J ±  kb
transcript NM_010251 RefSeq | MGI Sequence Detail 4123 C57BL/6 
polypeptide Q9D6F4 UniProt | EBI | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(285 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR005434 Gamma-aminobutyric-acid A receptor, alpha 4 subunit
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007769 gamma-aminobutyric acid receptor subunit alpha-4
Graphical View of Protein Domain Structure
References (Earliest) J:43551 Ymer S, et al., Sequence and expression of a novel GABAA receptor alpha subunit. FEBS Lett. 1989 Nov 20;258(1):119-22
(Latest) J:205569 Maguire EP, et al., Tonic Inhibition of Accumbal Spiny Neurons by Extrasynaptic alpha4betadelta GABAA Receptors Modulates the Actions of Psychostimulants. J Neurosci. 2014 Jan 15;34(3):823-38
All references(62)
Other
accession IDs
MGD-MRK-9925, MGD-MRK-9930

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory