About   Help   FAQ
Gabra2 Gene Detail
Summary
  • Symbol
    Gabra2
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
  • Synonyms
    C630048P16Rik, Gabra-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95614
    NCBI Gene: 14395
  • Gene Overview
    MyGene.info: GABRA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:70957597-71095849 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      138253 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 37.59 cM
  • Mapping Data
    14 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    GABRA2, gamma-aminobutyric acid type A receptor alpha2 subunit
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GABRA2, gamma-aminobutyric acid type A receptor alpha2 subunit
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2555
    neXtProt AC: NX_P47869
    UniProt: P47869

  • Chr Location
    4p12; chr4:46243548-46390039 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20217
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GABRA2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human GABRA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 6 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele are resistant to the anxiolytic effects of diazepam (DZP). Mice homozygous for a different knock-out allele exhibit reduced DZP-induced antihyperalgesia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054189 VEGA Gene Model | MGI Sequence Detail 138253 C57BL/6J ±  kb
    transcript OTTMUST00000134556 VEGA | MGI Sequence Detail 5852 Not Applicable  
    polypeptide OTTMUSP00000071349 VEGA | MGI Sequence Detail 451 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      480 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
    • InterPro Domains
      IPR005432 Gamma-aminobutyric-acid A receptor, alpha 2 subunit
      IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 12
      cDNA 13
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9923, MGD-MRK-9928, MGI:1925960
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 12
      Gene Ontology 7
      Phenotypes 48
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:249622 Benham RS, et al., Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking alpha2-containing GABAA receptors. Behav Brain Res. 2017 Aug 14;332:172-179

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory