Gabra2
Gene Detail

Symbol Name ID

Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 MGI:95614

STS

D5Buc15, D5Buc16, D5Buc17, D5Buc18

Synonyms

C630048P16Rik, Gabra-2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

37.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr5:70961057-71095849 bp, - strand From NCBI annotation of GRCm38   134793 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20217  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Gabra2

Human homologs

Human Homolog		GABRA2, gamma-aminobutyric acid (GABA) A receptor, alpha 2
NCBI Gene ID		2555
neXtProt AC		NX_P47869
Human Chr (Location)		4p12; chr4:46251575-46392056 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GABRA2

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a knockout allele are resistant to the anxiolytic effects of diazepam (DZP). Mice homozygous for a different knock-out allele exhibit reduced DZP-induced antihyperalgesia.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	chloride transport, gamma-aminobutyric acid signaling pathway, ...
Component	axon, cell junction, ...
Function	benzodiazepine receptor activity, chloride channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (53)    Tissues (12)    Images (24)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	42
Western blot	1
RT-PCR	9

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(12) cDNA(13) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000000560 (Evidence)
Entrez Gene	14395 (Evidence)
DFCI	TC1589022, TC1598547
DoTS	DT.40142109, DT.55205789, DT.94165402
NIA Mouse Gene Index	U026281
Consensus CDS Project	CCDS19327.1
International Mouse Knockout Project Status	Gabra2

Sequences

Length	Strain/Species
genomic	14395	NCBI Gene Model | MGI Sequence Detail	134793	C57BL/6J
transcript	NM_008066	RefSeq | MGI Sequence Detail	2392	C57BL/6
polypeptide	P26048	UniProt | EBI | MGI Sequence Detail	451	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(455 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR005432	Gamma-aminobutyric-acid A receptor, alpha 2 subunit
InterPro	IPR001390	Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007767	gamma-aminobutyric acid receptor subunit alpha-2

Graphical View of Protein Domain Structure

References

(Earliest) J:23686 Buckle VJ, et al., Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron. 1989 Nov;3(5):647-54
(Latest) J:192286 Dixon CI, et al., Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration. PLoS One. 2012;7(10):e47135
All references(77)

Other accession IDs

MGD-MRK-9923, MGD-MRK-9928, MGI:1925960