About   Help   FAQ
Gabra2
Gene Detail
 Symbol
Name
ID
Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
MGI:95614
STS D5Buc15, D5Buc16, D5Buc17, D5Buc18
Synonyms C630048P16Rik, Gabra-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
37.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr5:70961057-71095849 bp, - strand
From NCBI annotation of GRCm38

  134793 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20217  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Gabra2

Human
homologs
Human Homolog GABRA2, gamma-aminobutyric acid (GABA) A receptor, alpha 2
NCBI Gene ID 2555
neXtProt AC  NX_P47869
Human Chr (Location)  4p12; chr4:46244453-46390039 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GABRA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele are resistant to the anxiolytic effects of diazepam (DZP). Mice homozygous for a different knock-out allele exhibit reduced DZP-induced antihyperalgesia.
 
Interactions
Gabra2 interacts with 207 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process chloride transport, gamma-aminobutyric acid signaling pathway, ...
Component axon, cell junction, ...
Function benzodiazepine receptor activity, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (53)    Tissues (13)    Images (24)
Theiler Stages: 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 42
Western blot 1
RT-PCR 9
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(12) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000000560 (Evidence)
Entrez Gene14395 (Evidence)
DFCITC1589022, TC1598547
DoTSDT.40142109, DT.55205789, DT.94165402
NIA Mouse Gene IndexU026281
Consensus CDS ProjectCCDS19327.1
International Mouse Knockout Project StatusGabra2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14395 NCBI Gene Model | MGI Sequence Detail 134793 C57BL/6J ±  kb
transcript NM_008066 RefSeq | MGI Sequence Detail 2392 C57BL/6 
polypeptide P26048 UniProt | EBI | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(479 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006028 Gamma-aminobutyric acid A receptor
InterPro IPR005432 Gamma-aminobutyric-acid A receptor, alpha 2 subunit
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007767 gamma-aminobutyric acid receptor subunit alpha-2
Graphical View of Protein Domain Structure
References (Earliest) J:23686 Buckle VJ, et al., Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron. 1989 Nov;3(5):647-54
(Latest) J:205980 Heistek TS, et al., alpha2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations. J Physiol. 2013 Feb 15;591(Pt 4):845-58
All references(79)
Other
accession IDs
MGD-MRK-9923, MGD-MRK-9928, MGI:1925960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory