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Gabra2 Gene Detail
Summary
  • Symbol
    Gabra2
  • Name
    gamma-aminobutyric acid type A receptor subunit alpha 2
  • Synonyms
    C630048P16Rik, Gabra-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95614
    NCBI Gene: 14395
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:71115735-71253192 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 37.59 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3483 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95614
 protein coding gene Chr5:71114940-71253192 (-)
129S1/SvImJ ENSMUSG00200035195
 protein coding gene Chr5:66763054-66901292 (-)
A/J ENSMUSG00195029625
 protein coding gene Chr5:66095757-66234028 (-)
AKR/J ENSMUSG00220003938
 protein coding gene Chr5:66199111-66337390 (-)
BALB/cJ ENSMUSG00180019183
 protein coding gene Chr5:65850730-65989055 (-)
C3H/HeJ ENSMUSG00175024438
 protein coding gene Chr5:67917033-68055283 (-)
C57BL/6NJ ENSMUSG00215004545
 protein coding gene Chr5:66672205-66810449 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027277
 protein coding gene Chr5:63983093-64116611 (-)
CAST/EiJ ENSTCUG00005031165
 protein coding gene Chr5:65707680-65844392 (-)
CBA/J ENSMUSG00210023303
 protein coding gene Chr5:66844381-66982631 (-)
DBA/2J ENSMUSG00185005464
 protein coding gene Chr5:68685061-68823327 (-)
FVB/NJ ENSMUSG00205022647
 protein coding gene Chr5:65651522-65789804 (-)
JF1/MsJ ENSUMUG00000004815
 protein coding gene Chr5:73173620-73308371 (-)
LP/J ENSMUSG00230017641
 protein coding gene Chr5:73345997-73484254 (-)
NOD/ShiLtJ ENSMUSG00190004084
 protein coding gene Chr5:65780483-65918758 (-)
NZO/HlLtJ ENSMUSG00225008405
 protein coding gene Chr5:78418405-78556740 (-)
PWK/PhJ ENSLUMG00010013597
 protein coding gene Chr5:65761131-65895021 (-)
SPRET/EiJ ENSMSPG00010029001
 protein coding gene Chr5:67672296-67802394 (-)
WSB/EiJ ENSIUOG00005018023
 protein coding gene Chr5:68612285-68750574 (-)



Homology
more
  • Human Ortholog
    GABRA2, gamma-aminobutyric acid type A receptor subunit alpha2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRA2, gamma-aminobutyric acid type A receptor subunit alpha2
  • Synonyms
    DEE78, EIEE78
  • Links
    NCBI Gene ID: 2555
    UniProt: P47869

  • Chr Location
    4p12; chr4:46243548-46475230 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human GABRA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 7 alleles in 7 genetic backgrounds
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele are resistant to the anxiolytic effects of diazepam (DZP). Mice homozygous for a different knock-out allele exhibit reduced DZP-induced antihyperalgesia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    33
  • cDNA Data
    11
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14395 NCBI Gene Model | MGI Sequence Detail 137458 C57BL/6J ±  kb
    transcript NM_001428488 RefSeq | MGI Sequence Detail 5970 C57BL/6  
    polypeptide P26048 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007767 gamma-aminobutyric acid receptor subunit alpha-2
      (term hierarchy)
    • PDB
      5OSC
    • InterPro Domains
      IPR005432 Gamma-aminobutyric-acid A receptor, alpha 2 subunit
      IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR047024 Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
      IPR047023 Gamma-aminobutyric acid receptor subunit alpha-2, extracellular domain
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      P26048 3 sites, 7 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 12
      cDNA 14
      Primer pair 4
      Antibodies 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9923, MGD-MRK-9928, MGI:1925960
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 28
      Gene Ontology 14
      Phenotypes 99
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:386376 Faraci G, et al., The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2026 Apr 29;165:24-37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory