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Gabra2
Gene Detail
Symbol

Name
ID
Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
MGI:95614
Synonyms
C630048P16Rik, Gabra-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
37.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr5:70957597-71095849 bp, - strand
From VEGA annotation of GRCm38

  138253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20217  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GABRA2
Gene Tree: Gabra2

Human
homologs
GABRA2, gamma-aminobutyric acid (GABA) A receptor, alpha 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2555
neXtProt AC: NX_P47869

Human Chr (Location): 4p12; chr4:46243548-46390039 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GABRA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(7)
Genomic Mutations involving Gabra2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knockout allele are resistant to the anxiolytic effects of diazepam (DZP). Mice homozygous for a different knock-out allele exhibit reduced DZP-induced antihyperalgesia.
 
Phenotype Images(4)
Interactions
Gabra2 interacts with 206 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process chloride transport, gamma-aminobutyric acid signaling pathway, ...
Component axon, cell junction, ...
Function benzodiazepine receptor activity, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (53)    Tissues (13)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 42
Western blot 1
RT-PCR 9
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gabra2    NEW 
Molecular
reagents
All nucleic(28) Genomic(12) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000054189 (Evidence)
Ensembl Gene Model ENSMUSG00000000560 (Evidence)
Entrez Gene 14395 (Evidence)
DFCI TC1589022, TC1598547
DoTS DT.40142109, DT.55205789, DT.94165402
NIA Mouse Gene Index U026281
Consensus CDS Project CCDS19327.1
International Mouse Phenotyping Consortium Status Gabra2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054189 VEGA Gene Model | MGI Sequence Detail 138253 C57BL/6J ±  kb
transcript OTTMUST00000134556 VEGA | MGI Sequence Detail 5852 Not Applicable 
polypeptide OTTMUSP00000071349 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(480 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005432 Gamma-aminobutyric-acid A receptor, alpha 2 subunit
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology PR:000007767 gamma-aminobutyric acid receptor subunit alpha-2
References
(Earliest) J:23686 Buckle VJ, et al., Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron. 1989 Nov;3(5):647-54
(Latest) J:222724 Ralvenius WT, et al., Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype. Nat Commun. 2015;6:6803
All references(79)
Other
accession IDs
MGD-MRK-9923, MGD-MRK-9928, MGI:1925960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory