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Gabpb2 Gene Detail
Summary
  • Symbol
    Gabpb2
  • Name
    GA repeat binding protein, beta 2
  • Synonyms
    1810015F01Rik, 9430006E19Rik, A430024B14Rik, Gabpb2-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95612
    NCBI Gene: 213054
Location & Maps
more
  • Sequence Map
    Chr3:95181766-95217916 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36151 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    GABPB2, GA binding protein transcription factor beta subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GABPB2, GA binding protein transcription factor beta subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GABPB-2
  • Links
    NCBI Gene ID: 126626
    neXtProt AC: NX_Q8TAK5

  • Chr Location
    1q21.3; chr1:151070604-151129119 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    31
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Gabpb2
  • Incidental Mutations
    APF
Mice homozygous for a gene trapped allele are viable with normal T and B cell development but show increased B cell proliferation in response to B cell receptor stimulation, and moderately increased antibody production and germinal center responses when challenged with T-dependent antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022326 VEGA Gene Model | MGI Sequence Detail 36151 C57BL/6J ±  kb
transcript OTTMUST00000053220 VEGA | MGI Sequence Detail 8661 Not Applicable  
polypeptide OTTMUSP00000025295 VEGA | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    94 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007765 GA-binding protein subunit beta-2
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
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  • All nucleic 97
    Genomic 1
    cDNA 96

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-9921, MGI:1916324, MGI:1924499, MGI:2139930, MGI:2443474
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:19614 de la Brousse FC, et al., Molecular and genetic characterization of GABP beta. Genes Dev. 1994 Aug 1;8(15):1853-65
  • Latest
    J:206588 Mardaryev AN, et al., p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development. 2014 Jan;141(1):101-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory