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Gabpb2
Gene Detail
 Symbol
Name
ID
Gabpb2
GA repeat binding protein, beta 2
MGI:95612
Synonyms 1810015F01Rik, 9430006E19Rik, A430024B14Rik, Gabpb2-1
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr3:95181766-95217916 bp, - strand
From VEGA annotation of GRCm38

  36151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:34921  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: nuclear respiratory factor-2 beta-1 chain
Gene Tree: Gabpb2

Human
homologs
Human Homolog GABPB2, GA binding protein transcription factor, beta subunit 2
NCBI Gene ID 126626
neXtProt AC  NX_Q8TAK5
Human Chr (Location)  1q21.3; chr1:151070311-151118531 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(31) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trapped allele are viable with normal T and B cell development but show increased B cell proliferation in response to B cell receptor stimulation, and moderately increased antibody production and germinal center responses when challenged with T-dependent antigens.
 
Interactions
Gabpb2 interacts with 510 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function protein heterodimerization activity, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(95)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) Genomic(1) cDNA(96)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022326 (Evidence)
Ensembl Gene ModelENSMUSG00000038766 (Evidence)
Entrez Gene213054 (Evidence)
UniGene224820
DFCITC1585878, TC1589391, TC1590723, TC1613055, TC1619445, TC1625372, TC1668696, TC1715350
DoTSDT.101721913, DT.101725257, DT.111040721, DT.40181807, DT.531046, DT.60101129, DT.91335548, DT.91404714, DT.94125503, DT.94146100, DT.94187678
NIA Mouse Gene IndexU024357, U055686
Consensus CDS ProjectCCDS17605.1
International Mouse Knockout Project StatusGabpb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022326 VEGA Gene Model | MGI Sequence Detail 36151 C57BL/6J ±  kb
transcript OTTMUST00000053223 VEGA | MGI Sequence Detail 8357 Not Applicable 
polypeptide OTTMUSP00000025296 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(12) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000007765 GA-binding protein subunit beta-2
References (Earliest) J:19614 de la Brousse FC, et al., Molecular and genetic characterization of GABP beta. Genes Dev. 1994 Aug 1;8(15):1853-65
(Latest) J:206588 Mardaryev AN, et al., p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development. 2014 Jan;141(1):101-11
All references(40)
Other
accession IDs
MGD-MRK-9921, MGI:1916324, MGI:1924499, MGI:2139930, MGI:2443474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory