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Gabpb1 Gene Detail
Summary
  • Symbol
    Gabpb1
  • Name
    GA repeat binding protein, beta 1
  • Synonyms
    BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4Tf1B, GABPB1-1, GABPB1-2, NRF2B1, NRF2B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95611
    NCBI Gene: 14391
  • Gene Overview
    MyGene.info: GABPB1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126628907-126676551 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95611
protein coding gene Chr2:126627442-126676551 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026442
protein coding gene Chr2:129850834-129902974 (-)
A/J MGP_AJ_G0026405
protein coding gene Chr2:124591095-124640300 (-)
AKR/J MGP_AKRJ_G0026381
protein coding gene Chr2:128160965-128209739 (-)
BALB/cJ MGP_BALBcJ_G0026417
protein coding gene Chr2:124858389-124907527 (-)
C3H/HeJ MGP_C3HHeJ_G0026161
protein coding gene Chr2:128651047-128702194 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026863
protein coding gene Chr2:133981998-134033115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024240
protein coding gene Chr2:119313759-119365349 (-)
CAST/EiJ MGP_CASTEiJ_G0025622
protein coding gene Chr2:128869819-128920013 (-)
CBA/J MGP_CBAJ_G0026141
protein coding gene Chr2:138889173-138941517 (-)
DBA/2J MGP_DBA2J_G0026275
protein coding gene Chr2:124002437-124051773 (-)
FVB/NJ MGP_FVBNJ_G0026239
protein coding gene Chr2:122660877-122709852 (-)
LP/J MGP_LPJ_G0026380
protein coding gene Chr2:130111786-130162665 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026259
protein coding gene Chr2:142965237-143016991 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026918
protein coding gene Chr2:128183223-128232071 (-)
PWK/PhJ MGP_PWKPhJ_G0025358
protein coding gene Chr2:123542988-123592631 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025160
protein coding gene Chr2:127256555-127313316 (-)
WSB/EiJ MGP_WSBEiJ_G0025696
protein coding gene Chr2:129064336-129116549 (-)



Homology
more
  • Human Ortholog
    GABPB1, GA binding protein transcription factor subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABPB1, GA binding protein transcription factor subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB-1, GABPB2, NRF2B1, NRF2B2
  • Links
    NCBI Gene ID: 2553
    neXtProt AC: NX_Q06547
    UniProt: Q06547

  • Chr Location
    15q21.2; chr15:50277192-50355429 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality by E12.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14391 NCBI Gene Model | MGI Sequence Detail 47645 C57BL/6J ±  kb
    transcript NM_001271492 RefSeq | MGI Sequence Detail 3254 C57BL/6  
    polypeptide Q00420 UniProt | EBI | MGI Sequence Detail 383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 187
      Genomic 1
      cDNA 181
      Primer pair 3
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-9920
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:272987 Ryu D, et al., A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metab. 2014 Nov 4;20(5):856-869

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory