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Gabpb1 Gene Detail
Summary
  • Symbol
    Gabpb1
  • Name
    GA repeat binding protein, beta 1
  • Synonyms
    BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4Tf1B, GABPB1-1, GABPB1-2, NRF2B1, NRF2B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95611
    NCBI Gene: 14391
  • Gene Overview
    MyGene.info: GABPB1
Location & Maps
more
  • Sequence Map
    Chr2:126627442-126676337 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48896 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.76 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GABPB1, GA binding protein transcription factor beta subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABPB1, GA binding protein transcription factor beta subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB-1, GABPB2, NRF2B1, NRF2B2
  • Links
    NCBI Gene ID: 2553
    neXtProt AC: NX_Q06547

  • Chr Location
    15q21.2; chr15:50277192-50355408 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    76
  • Chemically induced (other)
    1
  • Gene trapped
    70
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gabpb1
  • Incidental Mutations
Mice homozygous for a null allele exhibit embryonic lethality by E12.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015863 VEGA Gene Model | MGI Sequence Detail 48896 C57BL/6J ±  kb
transcript OTTMUST00000037695 VEGA | MGI Sequence Detail 4153 Not Applicable  
polypeptide OTTMUSP00000016906 VEGA | MGI Sequence Detail 383 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    232 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000007764 GA-binding protein subunit beta-1
  • PDB
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
less
  • All nucleic 182
    Genomic 1
    cDNA 179
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-9920
References
more
  • Summaries
    All 38
    Developmental Gene Expression 7
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory