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Gabpa
Gene Detail
Symbol

Name
ID
Gabpa
GA repeat binding protein, alpha
MGI:95610
Synonyms
GABPalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 16
46.92 cM, cytoband C3-4
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr16:84834925-84863779 bp, + strand
From VEGA annotation of GRCm38

  28855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GABPA
Protein SuperFamily: GA-binding transcription factor,alpha subunit
Gene Tree: Gabpa

Human
homologs
GABPA, GA binding protein transcription factor, alpha subunit 60kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2551
neXtProt AC: NX_Q06546

Human Synonyms: E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07

Human Chr (Location): 21q21.3; chr21:25734947-25772460 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(104) : Gene trapped(96) Targeted(8)
Genomic Mutations involving Gabpa (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die early in embryonic development.
 
Interactions
Gabpa interacts with 375 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell differentiation, in utero embryonic development, ...
Component nuclear chromatin, nucleoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (234)    Tissues (183)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 179
Northern blot 16
Western blot 15
RT-PCR 24
cDNA source data(127)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GABPA ; Xenbase gabpa ; ZFIN gabpa    NEW 
Molecular
reagents
All nucleic(136) Genomic(2) cDNA(129) Primer pair(3) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000025176 (Evidence)
Ensembl Gene Model ENSMUSG00000008976 (Evidence)
Entrez Gene 14390 (Evidence)
UniGene 18974
DFCI TC1580548, TC1598601, TC1629082
DoTS DT.101123022, DT.101343280, DT.103587081, DT.103587109, DT.99869291
NIA Mouse Gene Index U043544
PDB 1AWC, 1SXD, 2JUO
Consensus CDS Project CCDS28284.1
International Mouse Phenotyping Consortium Status Gabpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025176 VEGA Gene Model | MGI Sequence Detail 28855 C57BL/6J ±  kb
transcript OTTMUST00000061964 VEGA | MGI Sequence Detail 4987 Not Applicable 
polypeptide OTTMUSP00000030491 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(9) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR024668 GA-binding protein alpha subunit, N-terminal
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR016312 Transcription factor, GA-binding, alpha subunit
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007763 GA-binding protein alpha chain
References
(Earliest) J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
(Latest) J:194335 Yang ZF, et al., GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2312-7
All references(70)
Other
accession IDs
MGD-MRK-9919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory