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Gabpa
Gene Detail
 Symbol
Name
ID
Gabpa
GA repeat binding protein, alpha
MGI:95610
Synonyms GABPalpha
Feature Type protein coding gene
Genetic Map
Chromosome 16
46.92 cM, cytoband C3-4
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr16:84834925-84863779 bp, + strand
From VEGA annotation of GRCm38

  28855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: GA-binding transcription factor,alpha subunit
Gene Tree: Gabpa

Human
homologs
Human Homolog GABPA, GA binding protein transcription factor, alpha subunit 60kDa
NCBI Gene ID 2551
neXtProt AC  NX_Q06546
Human Synonyms  E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
Human Chr (Location)  21q21.3; chr21:25734947-25772460 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(104) : Gene trapped(96) Targeted(8)
Genomic Mutations involving Gabpa (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die early in embryonic development.
 
Interactions
Gabpa interacts with 376 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process in utero embryonic development, negative regulation of megakaryocyte differentiation, ...
Component nuclear chromatin, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (234)    Tissues (182)    Images (29)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 18, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 179
Northern blot 16
Western blot 15
RT-PCR 24
cDNA source data(127)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(136) Genomic(2) cDNA(129) Primer pair(3) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000025176 (Evidence)
Ensembl Gene ModelENSMUSG00000008976 (Evidence)
Entrez Gene14390 (Evidence)
UniGene18974
DFCITC1580548, TC1598601, TC1629082
DoTSDT.101123022, DT.101343280, DT.103587081, DT.103587109, DT.99869291
NIA Mouse Gene IndexU043544
PDB1AWC, 1SXD, 2JUO
Consensus CDS ProjectCCDS28284.1
International Mouse Knockout Project StatusGabpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025176 VEGA Gene Model | MGI Sequence Detail 28855 C57BL/6J ±  kb
transcript OTTMUST00000061964 VEGA | MGI Sequence Detail 4987 Not Applicable 
polypeptide OTTMUSP00000030491 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(12) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR024668 GA-binding protein alpha subunit, N-terminal
InterPro IPR003118 Pointed domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR016312 Transcription factor, GA-binding, alpha subunit
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007763 GA-binding protein alpha chain
References (Earliest) J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
(Latest) J:194335 Yang ZF, et al., GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2312-7
All references(72)
Other
accession IDs
MGD-MRK-9919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory