Gabpa MGI Mouse Gene Detail - MGI:95610 - GA repeat binding protein, alpha

Symbol

Gabpa
Name

GA repeat binding protein, alpha
Synonyms

GABPalpha

Feature Type

protein coding gene
IDs

MGI:95610
NCBI Gene: 14390
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr16:84631813-84660667 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 46.92 cM, cytoband C3-4
Mapping Data

9 experiments

SNPs within 2kb

1553 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95610	protein coding gene	Chr16:84631795-84660671 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022970	protein coding gene	Chr16:85418210-85450209 (+)
A/J	MGP_AJ_G0022938	protein coding gene	Chr16:81524718-81554142 (+)
AKR/J	MGP_AKRJ_G0022908	protein coding gene	Chr16:83924767-83953602 (+)
BALB/cJ	MGP_BALBcJ_G0022940	protein coding gene	Chr16:81983221-82012317 (+)
C3H/HeJ	MGP_C3HHeJ_G0022702	protein coding gene	Chr16:84499882-84528693 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023387	protein coding gene	Chr16:88191574-88221651 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020891	protein coding gene	Chr16:79471442-79500439 (+)
CAST/EiJ	MGP_CASTEiJ_G0022224	protein coding gene	Chr16:84945609-84977679 (+)
CBA/J	MGP_CBAJ_G0022671	protein coding gene	Chr16:91949468-91983148 (+)
DBA/2J	MGP_DBA2J_G0022805	protein coding gene	Chr16:81404010-81432840 (+)
FVB/NJ	MGP_FVBNJ_G0022780	protein coding gene	Chr16:80603184-80632197 (+)
LP/J	MGP_LPJ_G0022874	protein coding gene	Chr16:85102518-85133817 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022799	protein coding gene	Chr16:96409167-96439635 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023405	protein coding gene	Chr16:84404040-84432828 (+)
PWK/PhJ	MGP_PWKPhJ_G0021966	protein coding gene	Chr16:81565938-81594870 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021796	protein coding gene	Chr16:83900394-83930687 (+)
WSB/EiJ	MGP_WSBEiJ_G0022272	protein coding gene	Chr16:84652363-84681893 (+)

Human Ortholog

GABPA, GA binding protein transcription factor subunit alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GABPA, GA binding protein transcription factor subunit alpha
Synonyms

E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
Links

HGNC:4071

NCBI Gene ID: 2551

UniProt: Q06546
Chr Location

21q21.3; chr21:25734570-25772460 (+) GRCh38

MGI Vertebrate Homology

Gabpa stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GABPA
Protein SuperFamily

GABP_alpha
Gene Tree

Gabpa

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References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 6 alleles in 5 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

96
Endonuclease-mediated

4
Gene trapped

82
Targeted

9
Genomic Mutations

4 involving Gabpa
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die early in embryonic development.

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All GO Annotations

39
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1072
Tissues

243
cDNA Data

134
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GABPA

Xenbase gabpa

ZFIN gabpa

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All Sequences

78
RefSeq

23
UniProt

6
CCDS

CCDS28284.1

Ensembl

ENSMUSG00000008976 (Evidence)
NCBI Gene

14390

			Length	Strain/Species	Flank
genomic	ENSMUSG00000008976	Ensembl Gene Model \| MGI Sequence Detail	28855	C57BL/6J	± kb
transcript	ENSMUST00000114184	Ensembl \| MGI Sequence Detail	2202	Not Applicable
polypeptide	ENSMUSP00000109822	Ensembl \| MGI Sequence Detail	454	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007763 GA-binding protein alpha chain

(term hierarchy)
PDB

1AWC, 1SXD, 2JUO
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR024668 GA-binding protein alpha subunit, N-terminal

IPR003118 Pointed domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR016312 Transcription factor, GA-binding, alpha subunit

IPR029071 Ubiquitin-like domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q00422 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 148

Genomic 2

cDNA 136

Primer pair 6

Other 4

Microarray probesets 7

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MGD-MRK-9919

Summaries

All 103

Developmental Gene Expression 22

Diseases 1

Gene Ontology 14

Phenotypes 36
Earliest

J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Gabpa:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139194	Chr16:84631768-84631775 (+)	-41 bp
Tssr139195	Chr16:84631789-84631829 (+)	-4 bp
Tssr139196	Chr16:84631831-84631843 (+)	24 bp
Tssr139197	Chr16:84631931-84631944 (+)	125 bp
Tssr139198	Chr16:84631958-84631985 (+)	159 bp
Tssr139199	Chr16:84632213-84632227 (+)	407 bp
Tssr139200	Chr16:84632228-84632239 (+)	421 bp
Tssr139201	Chr16:84632248-84632309 (+)	466 bp
Tssr139202	Chr16:84649498-84649507 (+)	17,690 bp
Tssr139203	Chr16:84649779-84649785 (+)	17,969 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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