Gabpa MGI Mouse Gene Detail - MGI:95610 - GA repeat binding protein, alpha

Gabpa Gene Detail

Symbol

Gabpa
Name

GA repeat binding protein, alpha
Synonyms

GABPalpha

Feature Type

protein coding gene
IDs

MGI:95610
NCBI Gene: 14390
Gene Overview

MyGene.info: GABPA

Sequence Map

Chr16:84834925-84863779 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

28855 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 46.92 cM, cytoband C3-4
Mapping Data

9 experiments

Human Ortholog

GABPA, GA binding protein transcription factor alpha subunit

Vertebrate Orthologs

10

Human Ortholog

GABPA, GA binding protein transcription factor alpha subunit
Orthology source: HomoloGene, HGNC
Synonyms

E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
Links

HGNC:4071

NCBI Gene ID: 2551

neXtProt AC: NX_Q06546
Chr Location

21q21.3; chr21:25734947-25772460 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 1543
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: GABPA
Protein SuperFamily

GA-binding transcription factor,alpha subunit
Gene Tree

Gabpa

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References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 6 alleles in 5 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

105
Gene trapped

96
Targeted

9
Genomic Mutations

3 involving Gabpa
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for disruptions in this gene die early in embryonic development.

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All GO Annotations

22
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

234
Tissues

183
cDNA Data

127
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA GABPA

Xenbase gabpa

ZFIN gabpa

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Gabpa interacts with 375 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

58
RefSeq

13
UniProt

6
CCDS

CCDS28284.1
UniGene

18974

			Length	Strain/Species	Flank
genomic	OTTMUSG00000025176	VEGA Gene Model \| MGI Sequence Detail	28855	C57BL/6J	± kb
transcript	OTTMUST00000061964	VEGA \| MGI Sequence Detail	4987	Not Applicable
polypeptide	OTTMUSP00000030491	VEGA \| MGI Sequence Detail	454	Not Applicable

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SNPs within 2kb

131 from dbSNP Build 142

RFLP

2

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UniProt

6 Sequences
Protein Ontology

PR:000007763 GA-binding protein alpha chain
PDB

1AWC, 1SXD, 2JUO
InterPro Domains

IPR000418 Ets domain

IPR024668 GA-binding protein alpha subunit, N-terminal

IPR003118 Pointed domain

IPR013761 Sterile alpha motif/pointed domain

IPR016312 Transcription factor, GA-binding, alpha subunit

IPR029071 Ubiquitin-related domain

IPR011991 Winged helix-turn-helix DNA-binding domain

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All nucleic 136

Genomic 2

cDNA 129

Primer pair 3

Other 2

Microarray probesets 7

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MGD-MRK-9919

Summaries

All 67

Developmental Gene Expression 16

Diseases 1

Gene Ontology 9

Phenotypes 23
Earliest

J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
Latest

J:224266 Yang ZF, et al., GABP transcription factor (nuclear respiratory factor 2) is required for mitochondrial biogenesis. Mol Cell Biol. 2014 Sep;34(17):3194-201

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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