About   Help   FAQ
Gabpa Gene Detail
Summary
  • Symbol
    Gabpa
  • Name
    GA repeat binding protein, alpha
  • Synonyms
    GABPalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95610
    NCBI Gene: 14390
  • Gene Overview
    MyGene.info: GABPA
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:84834925-84863779 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 46.92 cM, cytoband C3-4
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95610
protein coding gene Chr16:84834891-84863783 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022970
protein coding gene Chr16:85418210-85450209 (+)
A/J MGP_AJ_G0022938
protein coding gene Chr16:81524718-81554142 (+)
AKR/J MGP_AKRJ_G0022908
protein coding gene Chr16:83924767-83953602 (+)
BALB/cJ MGP_BALBcJ_G0022940
protein coding gene Chr16:81983221-82012317 (+)
C3H/HeJ MGP_C3HHeJ_G0022702
protein coding gene Chr16:84499882-84528693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023387
protein coding gene Chr16:88191574-88221651 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020891
protein coding gene Chr16:79471442-79500439 (+)
CAST/EiJ MGP_CASTEiJ_G0022224
protein coding gene Chr16:84945609-84977679 (+)
CBA/J MGP_CBAJ_G0022671
protein coding gene Chr16:91949468-91983148 (+)
DBA/2J MGP_DBA2J_G0022805
protein coding gene Chr16:81404010-81432840 (+)
FVB/NJ MGP_FVBNJ_G0022780
protein coding gene Chr16:80603184-80632197 (+)
LP/J MGP_LPJ_G0022874
protein coding gene Chr16:85102518-85133817 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022799
protein coding gene Chr16:96409167-96439635 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023405
protein coding gene Chr16:84404040-84432828 (+)
PWK/PhJ MGP_PWKPhJ_G0021966
protein coding gene Chr16:81565938-81594870 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021796
protein coding gene Chr16:83900394-83930687 (+)
WSB/EiJ MGP_WSBEiJ_G0022272
protein coding gene Chr16:84652363-84681893 (+)



Homology
more
  • Human Ortholog
    GABPA, GA binding protein transcription factor subunit alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABPA, GA binding protein transcription factor subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
  • Links
    NCBI Gene ID: 2551
    neXtProt AC: NX_Q06546
    UniProt: Q06546

  • Chr Location
    21q21.3; chr21:25734947-25772460 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 7 alleles in 6 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die early in embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008976 Ensembl Gene Model | MGI Sequence Detail 28855 C57BL/6J ±  kb
    transcript ENSMUST00000114184 Ensembl | MGI Sequence Detail 2202 Not Applicable  
    polypeptide ENSMUSP00000109822 Ensembl | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 145
      Genomic 2
      cDNA 135
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9919
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 11
      Phenotypes 29
    • Earliest
      J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
    • Latest
      J:269371 Chen Y, et al., Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature. 2019 Jan;565(7738):180-185

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory