Gabpa
Gene Detail

Symbol Name ID

Gabpa GA repeat binding protein, alpha MGI:95610

Synonyms

GABPalpha

Feature Type

protein coding gene

Genetic Map

Chromosome 16

46.92 cM, cytoband C3-4
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr16:84834925-84863779 bp, + strand From VEGA annotation of GRCm38   28855 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GA-binding transcription factor,alpha subunit
Gene Tree: Gabpa

Human homologs

Human Homolog		GABPA, GA binding protein transcription factor, alpha subunit 60kDa
NCBI Gene ID		2551
neXtProt AC		NX_Q06546
Human Synonyms		E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
Human Chr (Location)		21q21.3; chr21:25734947-25772460 (+)  GRCh38

Alleles and phenotypes

All alleles(102) : Gene trapped(96) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene die early in embryonic development.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	in utero embryonic development, negative regulation of megakaryocyte differentiation, ...
Component	nuclear chromatin, nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (241)    Tissues (187)    Images (29)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 18, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	179
Northern blot	16
Western blot	15
RT-PCR	31

cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(136) Genomic(2) cDNA(129) Primer pair(3) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000025176 (Evidence)
Ensembl Gene Model	ENSMUSG00000008976 (Evidence)
Entrez Gene	14390 (Evidence)
UniGene	18974
DFCI	TC1580548, TC1598601, TC1629082
DoTS	DT.101123022, DT.101343280, DT.103587081, DT.103587109, DT.99869291
NIA Mouse Gene Index	U043544
PDB	1AWC, 1SXD, 2JUO
Consensus CDS Project	CCDS28284.1
International Mouse Knockout Project Status	Gabpa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025176	VEGA Gene Model | MGI Sequence Detail	28855	C57BL/6J
transcript	OTTMUST00000061965	VEGA | MGI Sequence Detail	2202	Not Applicable
polypeptide	OTTMUSP00000030492	VEGA | MGI Sequence Detail	454	Not Applicable

All sequences(66) RefSeq(12) UniProt(6)

Polymorphisms

RFLP(2) : SNPs within 2kb(134 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000418	Ets domain
InterPro	IPR024668	GA-binding protein alpha subunit, N-terminal
InterPro	IPR003118	Pointed domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR016312	Transcription factor, GA-binding, alpha subunit
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007763	GA-binding protein alpha chain

References

(Earliest) J:20798 LaMarco K, et al., Identification of Ets- and notch-related subunits in GA binding protein [see comments]. Science. 1991 Aug 16;253(5021):789-92
(Latest) J:194335 Yang ZF, et al., GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2312-7
All references(72)

Other accession IDs

MGD-MRK-9919