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Xrcc6 Gene Detail
Summary
  • Symbol
    Xrcc6
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 6
  • Synonyms
    G22p1, Ku70, Ku p70
  • Feature Type
    protein coding gene
  • IDs
    MGI:95606
    NCBI Gene: 14375
  • Gene Overview
    MyGene.info: XRCC6
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:81987835-82040085 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 38.33 cM, cytoband E-F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95606
protein coding gene Chr15:81987825-82040085 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022129
protein coding gene Chr15:82468938-82523117 (+)
A/J MGP_AJ_G0022090
protein coding gene Chr15:79552738-79605103 (+)
AKR/J MGP_AKRJ_G0022065
protein coding gene Chr15:81751795-81803614 (+)
BALB/cJ MGP_BALBcJ_G0022095
protein coding gene Chr15:79598629-79651390 (+)
C3H/HeJ MGP_C3HHeJ_G0021866
protein coding gene Chr15:81772236-81827349 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022538
protein coding gene Chr15:85704646-85757554 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020067
protein coding gene Chr15:75993345-76046489 (+)
CAST/EiJ MGP_CASTEiJ_G0021386
protein coding gene Chr15:82561223-82618920 (+)
CBA/J MGP_CBAJ_G0021831
protein coding gene Chr15:88377297-88431517 (+)
DBA/2J MGP_DBA2J_G0021960
protein coding gene Chr15:79025380-79077420 (+)
FVB/NJ MGP_FVBNJ_G0021937
protein coding gene Chr15:78072593-78127384 (+)
LP/J MGP_LPJ_G0022028
protein coding gene Chr15:82609199-82666937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021958
protein coding gene Chr15:93302006-93355312 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022553
protein coding gene Chr15:81850164-81908796 (+)
PWK/PhJ MGP_PWKPhJ_G0021128
protein coding gene Chr15:79074913-79129669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020967
protein coding gene Chr15:81645128-81705013 (+)
WSB/EiJ MGP_WSBEiJ_G0021438
protein coding gene Chr15:82281359-82332868 (+)



Homology
more
  • Human Ortholog
    XRCC6, X-ray repair cross complementing 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    XRCC6, X-ray repair cross complementing 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTC75, CTCBF, G22P1, KU70, ML8, TLAA
  • Links
    NCBI Gene ID: 2547
    neXtProt AC: NX_P12956
    UniProt: P12956

  • Chr Location
    22q13.2; chr22:41621163-41664048 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neuron apoptosis, decreased body size, abnormal B and T cell morphology, increased incidence of tumorigenesis, and increased cellular sensitivity to irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022471 Ensembl Gene Model | MGI Sequence Detail 52251 C57BL/6J ±  kb
    transcript ENSMUST00000100399 Ensembl | MGI Sequence Detail 3296 Not Applicable  
    polypeptide ENSMUSP00000097968 Ensembl | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 2
      cDNA 99
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9914
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 13
      Phenotypes 65
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:261945 Maekawa T, et al., ATF7 mediates TNF-alpha-induced telomere shortening. Nucleic Acids Res. 2018 May 18;46(9):4487-4504

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory