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Xrcc6 Gene Detail
Summary
  • Symbol
    Xrcc6
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 6
  • Synonyms
    G22p1, Ku70, Ku p70
  • Feature Type
    protein coding gene
  • IDs
    MGI:95606
    NCBI Gene: 14375
  • Gene Overview
    MyGene.info: XRCC6
Location & Maps
more
  • Sequence Map
    Chr15:81987835-82040085 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52251 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6
    Orthology source: HomoloGene
  • Synonyms
    CTC75, CTCBF, G22P1, KU70, ML8, TLAA
  • Links
    NCBI Gene ID: 2547
    neXtProt AC: NX_P12956

  • Chr Location
    22q13.2; chr22:41621163-41664048 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    36
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Xrcc6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit neuron apoptosis, decreased body size, abnormal B and T cell morphology, increased incidence of tumorigenesis, and increased cellular sensitivity to irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035734 VEGA Gene Model | MGI Sequence Detail 52251 C57BL/6J ±  kb
transcript OTTMUST00000091361 VEGA | MGI Sequence Detail 3296 Not Applicable  
polypeptide OTTMUSP00000050322 VEGA | MGI Sequence Detail 608 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    330 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 101
    Genomic 2
    cDNA 98
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9914
References
more
  • Summaries
    All 99
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 12
    Phenotypes 62
  • Earliest
    J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
  • Latest
    J:220823 Jiang W, et al., Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Mol Cell. 2015 Apr 2;58(1):172-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory