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Xrcc6
Gene Detail
Symbol

Name
ID
Xrcc6
X-ray repair complementing defective repair in Chinese hamster cells 6
MGI:95606
Synonyms
G22p1, Ku70, Ku p70
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.33 cM, cytoband E-F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:81987835-82040085 bp, + strand
From VEGA annotation of GRCm38

  52251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: XRCC6
Protein SuperFamily: Ku DNA-binding complex, Ku70 subunit
Gene Tree: Xrcc6

Human
homologs
XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2547
neXtProt AC: NX_P12956

Human Synonyms: CTC75, CTCBF, G22P1, KU70, ML8, TLAA

Human Chr (Location): 22q13.2; chr22:41621163-41664048 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Chemically induced (ENU)(1) Gene trapped(36) Radiation induced(1) Targeted(6)
Genomic Mutations involving Xrcc6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neuron apoptosis, decreased body size, abnormal B and T cell morphology, increased incidence of tumorigenesis, and increased cellular sensitivity to irradiation.
 
Phenotype Images(2)
Interactions
Xrcc6 interacts with 64 markers (Mir17, Mir20b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process cellular hyperosmotic salinity response, cellular response to DNA damage stimulus, ...
Component chromosome, cytoplasm, ...
Function 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (103)    Tissues (22)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
RT-PCR 8
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase xrcc6 ; ZFIN xrcc6    NEW 
Molecular
reagents
All nucleic(101) Genomic(2) cDNA(98) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035734 (Evidence)
Ensembl Gene Model ENSMUSG00000022471 (Evidence)
Entrez Gene 14375 (Evidence)
UniGene 288809
DFCI TC1575377, TC1629928, TC1684514
DoTS DT.101390581, DT.110810173, DT.491519, DT.94216367
EC 3.6.4.-, 4.2.99.-
Consensus CDS Project CCDS37153.1
International Mouse Phenotyping Consortium Status Xrcc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035734 VEGA Gene Model | MGI Sequence Detail 52251 C57BL/6J ±  kb
transcript OTTMUST00000091361 VEGA | MGI Sequence Detail 3296 Not Applicable 
polypeptide OTTMUSP00000050322 VEGA | MGI Sequence Detail 608 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(15) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(332 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006165 Ku70
InterPro IPR027388 Ku70, bridge and pillars domain
InterPro IPR006164 Ku70/Ku80 beta-barrel domain
InterPro IPR005160 Ku70/Ku80 C-terminal arm
InterPro IPR005161 Ku70/Ku80, N-terminal alpha/beta
InterPro IPR003034 SAP domain
InterPro IPR016194 SPOC like C-terminal domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000017509 X-ray repair cross-complementing protein 6
References
(Earliest) J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
(Latest) J:220823 Jiang W, et al., Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Mol Cell. 2015 Apr 2;58(1):172-85
All references(100)
Other
accession IDs
MGD-MRK-9914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory