Xrcc6
Gene Detail

Symbol Name ID

Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 MGI:95606

Synonyms

G22p1, Ku70, Ku p70

Feature Type

protein coding gene

Genetic Map

Chromosome 15

38.33 cM, cytoband E-F
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:81987835-82040085 bp, + strand From VEGA annotation of GRCm38   52251 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37483  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Ku DNA-binding complex, Ku70 subunit
Gene Tree: Xrcc6

Human homologs

Human Homolog		XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6
NCBI Gene ID		2547
neXtProt AC		NX_P12956
Human Synonyms		CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Human Chr (Location)		22q13.2; chr22:42017295-42060052 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(43) : Targeted(6) Gene trapped(36) Chemically induced(1)
 

Mice homozygous for a knock-out allele exhibit neuron apoptosis, decreased body size, abnormal B and T cell morphology, increased incidence of tumorigenesis, and increased cellular sensitivity to irradiation.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	cellular hyperosmotic salinity response, cellular response to X-ray, ...
Component	chromosome, cytoplasm, ...
Function	5'-deoxyribose-5-phosphate lyase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (110)    Tissues (27)    Images (24)
Theiler Stages: 2, 3, 4, 5, 19, 23, 28

Assay Type	Results
RNA in situ	95
RT-PCR	15

cDNA source data(100)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) Genomic(2) cDNA(102) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035734 (Evidence)
Ensembl Gene Model	ENSMUSG00000022471 (Evidence)
Entrez Gene	14375 (Evidence)
UniGene	288809
DFCI	TC1575377, TC1629928, TC1684514
DoTS	DT.101390581, DT.110810173, DT.491519, DT.94216367
EC	3.6.4.-, 4.2.99.-
Consensus CDS Project	CCDS37153.1
International Mouse Knockout Project Status	Xrcc6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035734	VEGA Gene Model | MGI Sequence Detail	52251	C57BL/6J
transcript	OTTMUST00000091361	VEGA | MGI Sequence Detail	3296	Not Applicable
polypeptide	OTTMUSP00000050322	VEGA | MGI Sequence Detail	608	Not Applicable

All sequences(80) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006165	Ku70
InterPro	IPR006164	Ku70/Ku80 beta-barrel domain
InterPro	IPR005160	Ku70/Ku80 C-terminal arm
InterPro	IPR005161	Ku70/Ku80, N-terminal alpha/beta
InterPro	IPR003034	SAP domain
InterPro	IPR016194	SPOC like C-terminal domain
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000017509	ATP-dependent DNA helicase 2 subunit 1

References

(Earliest) J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
(Latest) J:194333 Oksenych V, et al., Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2234-9
All references(94)

Other accession IDs

MGD-MRK-9914