Fut4
Gene Detail

Symbol Name ID

Fut4 fucosyltransferase 4 MGI:95594

Synonyms

3-fucosyl-N-acetyl-lactosamine epitope, FAL, FucT-IV, LeX, Ssea1, SSEA-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

4.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:14748459-14752122 bp, - strand From NCBI annotation of GRCm38   3664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: fucosyltransferase
Gene Tree: Fut4

Human homologs

Human Homolog		FUT4, fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
NCBI Gene ID		2526
neXtProt AC		NX_P22083
Human Synonyms		CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1
Human Chr (Location)		11q21; chr11:94277017-94283064 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele show a modest increase in blood neutrophils, monocytes and eosinophils, and increased leukocyte rolling velocities.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	fucosylation, protein glycosylation
Component	cell periphery, cell surface, ...
Function	alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (73 records)
Data Summary: Results (209)    Tissues (185)    Images (33)
Theiler Stages: 1, 2, 3, 5, 9, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	115
RNA in situ	94

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(2) cDNA(11) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000049307 (Evidence)
Entrez Gene	14345 (Evidence)
UniGene	63450
DFCI	TC1585571, TC1661089
DoTS	DT.40171675, DT.91334210
NIA Mouse Gene Index	U030486
EC	2.4.1.-
Consensus CDS Project	CCDS22825.1
International Mouse Knockout Project Status	Fut4

Sequences

Length	Strain/Species
genomic	14345	NCBI Gene Model | MGI Sequence Detail	3664	C57BL/6J
transcript	NM_010242	RefSeq | MGI Sequence Detail	3664	C57BL/6
polypeptide	Q11127	UniProt | EBI | MGI Sequence Detail	433	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001503	Glycosyl transferase, family 10
Protein Ontology	PR:000001456	alpha-(1,3)-fucosyltransferase FUT4

Graphical View of Protein Domain Structure

References

(Earliest) J:71489 Solter D, et al., Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U S A. 1978 Nov;75(11):5565-9
(Latest) J:191131 Chen L, et al., Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15;22(2):313-27
All references(142)

Other accession IDs

MGD-MRK-9894, MGI:2143062