Fuca1
Gene Detail

Symbol Name ID

Fuca1 fucosidase, alpha-L- 1, tissue MGI:95593

Synonyms

0610006A03Rik, 9530055J05Rik, Afuc

Feature Type

protein coding gene

Genetic Map

Chromosome 4

68.01 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr4:135920735-135940311 bp, + strand From VEGA annotation of GRCm38   19577 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: alpha-L-fucosidase
Gene Tree: Fuca1

Human homologs

Human Homolog		FUCA1, fucosidase, alpha-L- 1, tissue
NCBI Gene ID		2517
neXtProt AC		NX_P04066
Human Synonyms		FUCA
Human Chr (Location)		1p34; chr1:24171567-24194859 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FUCA1

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Strain differences are probably due to a structural variant in Fuca1. Strains A/J, BDP, LP, P, SEA/Gn and 129/J have high FUCA activity and high heat stability; C57BL/6, C3H/He, DBA/2, BALB/c and 22 other strains have low activity and low heat stability.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	carbohydrate metabolic process, fucose metabolic process, ...
Component	lysosome
Function	alpha-L-fucosidase activity, carbohydrate binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (95)    Tissues (95)    Images (12)
Theiler Stages: 22

Assay Type	Results
RNA in situ	95

cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) Genomic(3) cDNA(135)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000009850 (Evidence)
Ensembl Gene Model	ENSMUSG00000028673 (Evidence)
Entrez Gene	71665 (Evidence)
UniGene	439940
DFCI	TC1572263, TC1608502, TC1723403
DoTS	DT.101394384, DT.110841549, DT.110841836, DT.536420, DT.94271134, DT.94326307, DT.97352583
NIA Mouse Gene Index	U004955
EC	3.2.1.51
Consensus CDS Project	CCDS18794.1
International Mouse Knockout Project Status	Fuca1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009850	VEGA Gene Model | MGI Sequence Detail	19577	C57BL/6J
transcript	OTTMUST00000022831	VEGA | MGI Sequence Detail	2525	Not Applicable
polypeptide	OTTMUSP00000010414	VEGA | MGI Sequence Detail	452	Not Applicable

All sequences(51) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(131 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013781	Glycoside hydrolase, catalytic domain
InterPro	IPR000933	Glycoside hydrolase, family 29
InterPro	IPR016286	Glycoside hydrolase, family 29, bacteria/metazoa/fungi
InterPro	IPR018526	Glycoside hydrolase, family 29, conserved site
InterPro	IPR017853	Glycoside hydrolase, superfamily
Protein Ontology	PR:000007697	tissue alpha-L-fucosidase

References

(Earliest) J:6100 Self SJ, et al., Strain variation in spermatozoal glycosidases in inbred mice. Genet Res. 1978 Oct;32(2):183-93
(Latest) J:182706 Phopin K, et al., Distribution, crypticity, stability, and localization of alpha-L-fucosidase of mouse cauda epididymal sperm. Mol Reprod Dev. 2012 Mar;79(3):208-17
All references(50)

Other accession IDs

MGD-MRK-1179, MGD-MRK-9892, MGI:1918915, MGI:1925799