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Fuca1
Gene Detail
 Symbol
Name
ID
Fuca1
fucosidase, alpha-L- 1, tissue
MGI:95593
Synonyms 0610006A03Rik, 9530055J05Rik, Afuc
Feature Type protein coding gene
Genetic Map
Chromosome 4
68.01 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr4:135920735-135940311 bp, + strand
From VEGA annotation of GRCm38

  19577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20078  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: alpha-L-fucosidase
Gene Tree: Fuca1

Human
homologs
Human Homolog FUCA1, fucosidase, alpha-L- 1, tissue
NCBI Gene ID 2517
neXtProt AC  NX_P04066
Human Synonyms  FUCA
Human Chr (Location)  1p34; chr1:23845077-23868369 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FUCA1
Alleles
and
phenotypes
All alleles(14) : Targeted(4) Gene trapped(10)
 
Strain differences are probably due to a structural variant in Fuca1. Strains A/J, BDP, LP, P, SEA/Gn and 129/J have high FUCA activity and high heat stability; C57BL/6, C3H/He, DBA/2, BALB/c and 22 other strains have low activity and low heat stability.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process carbohydrate metabolic process, fucose metabolic process, ...
Component extracellular vesicular exosome, lysosome
Function alpha-L-fucosidase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (95)    Tissues (95)    Images (12)
Theiler Stages: 22
Assay TypeResults
RNA in situ 95
cDNA source data(135)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(138) Genomic(3) cDNA(135)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009850 (Evidence)
Ensembl Gene ModelENSMUSG00000028673 (Evidence)
Entrez Gene71665 (Evidence)
UniGene439940
DFCITC1572263, TC1608502, TC1723403
DoTSDT.101394384, DT.110841549, DT.110841836, DT.536420, DT.94271134, DT.94326307, DT.97352583
NIA Mouse Gene IndexU004955
EC3.2.1.51
Consensus CDS ProjectCCDS18794.1
International Mouse Knockout Project StatusFuca1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009850 VEGA Gene Model | MGI Sequence Detail 19577 C57BL/6J ±  kb
transcript OTTMUST00000022831 VEGA | MGI Sequence Detail 2525 Not Applicable 
polypeptide OTTMUSP00000010414 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR000933 Glycoside hydrolase, family 29
InterPro IPR016286 Glycoside hydrolase, family 29, bacteria/metazoa/fungi
InterPro IPR018526 Glycoside hydrolase, family 29, conserved site
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR013780 Glycosyl hydrolase, family 13, all-beta
Protein Ontology PR:000007697 tissue alpha-L-fucosidase
References (Earliest) J:6100 Self SJ, et al., Strain variation in spermatozoal glycosidases in inbred mice. Genet Res. 1978 Oct;32(2):183-93
(Latest) J:196085 Phopin K, et al., Roles of mouse sperm-associated alpha-L-fucosidases in fertilization. Mol Reprod Dev. 2013 Apr;80(4):273-85
All references(52)
Other
accession IDs
MGD-MRK-1179, MGD-MRK-9892, MGI:1918915, MGI:1925799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory