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Fuca1 Gene Detail
Summary
  • Symbol
    Fuca1
  • Name
    fucosidase, alpha-L- 1, tissue
  • Synonyms
    0610006A03Rik, 9530055J05Rik, Afuc
  • Feature Type
    protein coding gene
  • IDs
    MGI:95593
    NCBI Gene: 71665
  • Gene Overview
    MyGene.info: FUCA1
Location & Maps
more
  • Sequence Map
    Chr4:135920735-135940311 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19577 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.01 cM, cytoband D3
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    FUCA1, fucosidase, alpha-L- 1, tissue
  • Vertebrate Orthologs
    12
  • Human Ortholog
    FUCA1, fucosidase, alpha-L- 1, tissue
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FUCA
  • Links
    NCBI Gene ID: 2517
    neXtProt AC: NX_P04066

  • Chr Location
    1p34; chr1:23845077-23868369 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FUCA1 associations

Human Disease Mouse Models
       Fucosidosis   OMIM: 230000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    10
  • Targeted
    5
  • Genomic Mutations
    3 involving Fuca1
  • Incidental Mutations
Strain differences are probably due to a structural variant in Fuca1. Strains A/J, BDP, LP, P, SEA/Gn and 129/J have high FUCA activity and high heat stability; C57BL/6, C3H/He, DBA/2, BALB/c and 22 other strains have low activity and low heat stability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009850 VEGA Gene Model | MGI Sequence Detail 19577 C57BL/6J ±  kb
transcript OTTMUST00000022831 VEGA | MGI Sequence Detail 2525 Not Applicable  
polypeptide OTTMUSP00000010414 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 138
    Genomic 3
    cDNA 135

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1179, MGD-MRK-9892, MGI:1918915, MGI:1925799
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:6100 Self SJ, et al., Strain variation in spermatozoal glycosidases in inbred mice. Genet Res. 1978 Oct;32(2):183-93
  • Latest
    J:196085 Phopin K, et al., Roles of mouse sperm-associated alpha-L-fucosidases in fertilization. Mol Reprod Dev. 2013 Apr;80(4):273-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory