About   Help   FAQ
Ftl1 Gene Detail
Summary
  • Symbol
    Ftl1
  • Name
    ferritin light polypeptide 1
  • Synonyms
    Ftl, L-ferritin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95589
    NCBI Gene: 14325
Location & Maps
more
  • Sequence Map
    Chr7:45457944-45459884 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1941 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FTL, ferritin, light polypeptide
  • Vertebrate Orthologs
    22
  • Human Ortholog
    FTL, ferritin, light polypeptide
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LFTD, NBIA3
  • Links
    NCBI Gene ID: 2512
    neXtProt AC: NX_P02792

  • Chr Location
    19q13.33; chr19:48965309-48966879 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human FTL associations

Human Disease Mouse Models
       Hyperferritinemia with or without Cataract   OMIM: 600886
L-Ferritin Deficiency; LFTD   OMIM: 615604
Neurodegeneration with Brain Iron Accumulation 3; NBIA3   OMIM: 606159 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    1
  • Transgenic
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022565 VEGA Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
transcript OTTMUST00000054058 VEGA | MGI Sequence Detail 968 Not Applicable  
polypeptide OTTMUSP00000025746 VEGA | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    44 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 1
    cDNA 41
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9885, MGD-MRK-9886, MGD-MRK-9888
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:9732 Beaumont C, et al., Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. J Biol Chem. 1989 May 5;264(13):7498-504
  • Latest
    J:218500 Fan Y, et al., The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages. Biochim Biophys Acta. 2014 Nov;1843(11):2775-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory