Ftl1
Gene Detail

Symbol

Name
ID

Ftl1
ferritin light chain 1
MGI:95589

Synonyms

Ftl, L-ferritin

Feature Type

protein coding gene

Genetic Map

Chromosome 7
29.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:45457944-45459884 bp, - strand From VEGA annotation of GRCm38   1941 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:79330  Vertebrate Homology Class
1 human; 2 mouse; 8 rat; 1 chimpanzee; 3 rhesus macaque; 4 cattle; 2 dog; 1 western clawed frog

Protein SuperFamily: ferritin
Gene Tree: Ftl1

Human
homologs

Human Homolog		FTL, ferritin, light polypeptide
NCBI Gene ID		2512
neXtProt AC		NX_P02792
Human Synonyms		LFTD, NBIA3
Human Chr (Location)		19q13.33; chr19:48965309-48966879 (+)  GRCh38
Disease Associations		(3) Diseases Associated with Human FTL

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Gene trapped(1) Targeted(1) Transgenic(1)
Incidental mutations (data from APF )
Human Diseases Modeled in Mice Using Ftl1 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Ftl1 interacts with 60 markers (Mir22, Mir92-1, Mir133a-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (6 annotations)

Component	cytoplasm, extracellular vesicular exosome, ...
Function	identical protein binding, iron ion binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (14)    Tissues (11)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	12
RT-PCR	2

cDNA source data(38)
External Resources: GEO   Expression Atlas

Molecular
reagents

All nucleic(43) Genomic(1) cDNA(41) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000022565 (Evidence)
Ensembl Gene Model	ENSMUSG00000050708 (Evidence)
Entrez Gene	14325 (Evidence)
DoTS	DT.101123906, DT.101374525, DT.101374656, DT.103576057, DT.40170879, DT.91403229, DT.94222407, DT.94235556, DT.99871270
Consensus CDS Project	CCDS39952.1
International Mouse Knockout Project Status	Ftl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022565	VEGA Gene Model | MGI Sequence Detail	1941	C57BL/6J
transcript	OTTMUST00000054058	VEGA | MGI Sequence Detail	968	Not Applicable
polypeptide	OTTMUSP00000025746	VEGA | MGI Sequence Detail	183	Not Applicable

All sequences(80) RefSeq(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(44 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
Protein Ontology	PR:000007738	ferritin light chain 1

References

(Earliest) J:9732 Beaumont C, et al., Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. J Biol Chem. 1989 May 5;264(13):7498-504
(Latest) J:176655 Moroishi T, et al., The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo. Cell Metab. 2011 Sep 7;14(3):339-51
All references(41)

Other
accession IDs

MGD-MRK-9885, MGD-MRK-9886, MGD-MRK-9888