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Ftl1 Gene Detail
Summary
  • Symbol
    Ftl1
  • Name
    ferritin light polypeptide 1
  • Synonyms
    Ftl, L-ferritin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95589
    NCBI Gene: 14325
  • Gene Overview
    MyGene.info: FTL
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:45457944-45459884 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      1941 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FTL, ferritin light chain
  • Vertebrate Orthologs
    22
  • Human Ortholog
    FTL, ferritin light chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LFTD, NBIA3
  • Links
    NCBI Gene ID: 2512
    neXtProt AC: NX_P02792
    UniProt: P02792

  • Chr Location
    19q13.33; chr19:48965309-48966879 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human FTL associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial lethality during organogenesis, decreased circulating, liver and reticuloendothelial cell iron levels, head tilt, and unidirectional circling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    14
  • Tissues
    11
  • cDNA Data
    37
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022565 VEGA Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
    transcript OTTMUST00000054058 VEGA | MGI Sequence Detail 968 Not Applicable  
    polypeptide OTTMUSP00000025746 VEGA | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      44 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 41
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9885, MGD-MRK-9886, MGD-MRK-9888
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:9732 Beaumont C, et al., Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. J Biol Chem. 1989 May 5;264(13):7498-504
    • Latest
      J:254339 Garringer HJ, et al., Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy. PLoS One. 2016;11(8):e0161341
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory