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Ftl1 Gene Detail
Summary
  • Symbol
    Ftl1
  • Name
    ferritin light polypeptide 1
  • Synonyms
    Ftl, L-ferritin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95589
    NCBI Gene: 14325
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45107368-45109308 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95589
 protein coding gene Chr7:45107368-45109310 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032223
 protein coding gene Chr7:45721128-45724303 (-)
A/J MGP_AJ_G0032202
 protein coding gene Chr7:44844587-44846701 (-)
AKR/J MGP_AKRJ_G0032138
 protein coding gene Chr7:46088783-46090217 (-)
BALB/cJ MGP_BALBcJ_G0032214
 protein coding gene Chr7:44833702-44835914 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032706
 protein coding gene Chr7:47990591-47995147 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029720
 protein coding gene Chr7:47393031-47394947 (-)
CAST/EiJ MGP_CASTEiJ_G0031258
 protein coding gene Chr7:37996874-37999856 (-)
CBA/J MGP_CBAJ_G0031894
 protein coding gene Chr7:49573778-49578569 (-)
DBA/2J MGP_DBA2J_G0032052
 protein coding gene Chr7:44508115-44510062 (-)
FVB/NJ MGP_FVBNJ_G0032003
 protein coding gene Chr7:44292830-44294830 (-)
LP/J MGP_LPJ_G0032130
 protein coding gene Chr7:46419134-46420904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032040
 protein coding gene Chr7:48270049-48271562 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032722
 protein coding gene Chr7:45301040-45304309 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030818
 protein coding gene Chr7:33309055-33310825 (-)
WSB/EiJ MGP_WSBEiJ_G0031375
 protein coding gene Chr7:45797341-45799270 (-)



Homology
more
  • Human Ortholog
    FTL, ferritin light chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FTL, ferritin light chain
  • Synonyms
    LFTD, NBIA3
  • Links
    NCBI Gene ID: 2512
    neXtProt AC: NX_P02792
    UniProt: P02792

  • Chr Location
    19q13.33; chr19:48965309-48966879 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    4 with human FTL associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 2 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial lethality during organogenesis, decreased circulating, liver and reticuloendothelial cell iron levels, head tilt, and unidirectional circling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    11
  • cDNA Data
    37
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050708 Ensembl Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
    transcript ENSMUST00000094434 Ensembl | MGI Sequence Detail 968 Not Applicable  
    polypeptide ENSMUSP00000092002 Ensembl | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 41
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9885, MGD-MRK-9886, MGD-MRK-9888
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:9732 Beaumont C, et al., Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. J Biol Chem. 1989 May 5;264(13):7498-504
    • Latest
      J:317814 Fan L, et al., Lif Deficiency Leads to Iron Transportation Dysfunction in Ameloblasts. J Dent Res. 2022 Jan;101(1):63-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    08/03/2022
    MGI 6.21     		The Jackson Laboratory