Ftl1 MGI Mouse Gene Detail - MGI:95589 - ferritin light polypeptide 1

Ftl1 Gene Detail

Symbol

Ftl1
Name

ferritin light polypeptide 1
Synonyms

Ftl, L-ferritin

Feature Type

protein coding gene
IDs

MGI:95589
NCBI Gene: 14325
Gene Overview

MyGene.info: FTL

Sequence Map

Chr7:45457944-45459884 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

1941 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.32 cM
Mapping Data

4 experiments

Human Ortholog

FTL, ferritin light chain

Vertebrate Orthologs

22

Human Ortholog

FTL, ferritin light chain
Orthology source: HomoloGene, HGNC
Synonyms

LFTD, NBIA3
Links

HGNC:3999

NCBI Gene ID: 2512

neXtProt AC: NX_P02792

UniProt: P02792
Chr Location

19q13.33; chr19:48965309-48966879 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 79330
1 human;2 mouse;8 rat;1 chimpanzee;4 cattle;2 dog;1 frog, western clawed;3 macaque, rhesus
HCOP

human homology predictions: FTL
Protein SuperFamily

ferritin
Gene Tree

Ftl1

Diseases

1 with human FTL associations

Human Disease

Mouse Models

neurodegeneration with brain iron accumulation 3

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

21 phenotypes from multigenic genotypes
7 phenotype references

All Mutations and Alleles

4
Gene trapped

1
Targeted

1
Transgenic

2
Incidental Mutations

APF
Find Mice (IMSR)

4 strains or lines available

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All GO Annotations

11
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

14
Tissues

11
cDNA Data

37
Literature Summary

5

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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Ftl1 interacts with 60 markers (Mir22, Mir92-1, Mir133a-1, ...) View All

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All Sequences

80
RefSeq

2
UniProt

1
CCDS

CCDS39952.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022565	VEGA Gene Model \| MGI Sequence Detail	1941	C57BL/6J	± kb
transcript	OTTMUST00000054058	VEGA \| MGI Sequence Detail	968	Not Applicable
polypeptide	OTTMUSP00000025746	VEGA \| MGI Sequence Detail	183	Not Applicable

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SNPs within 2kb

44 from dbSNP Build 142

RFLP

1

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UniProt

1 Sequence
Protein Ontology

PR:000007738 ferritin light chain 1

(term hierarchy)

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All nucleic 43

Genomic 1

cDNA 41

Primer pair 1

Microarray probesets 3

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MGD-MRK-9885, MGD-MRK-9886, MGD-MRK-9888

Summaries

All 51

Developmental Gene Expression 5

Diseases 2

Gene Ontology 5

Phenotypes 7
Earliest

J:9732 Beaumont C, et al., Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. J Biol Chem. 1989 May 5;264(13):7498-504
Latest

J:237101 Arosio P, et al., The importance of eukaryotic ferritins in iron handling and cytoprotection. Biochem J. 2015 Nov 15;472(1):1-15

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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