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Ftl1
Gene Detail
Symbol

Name
ID
Ftl1
ferritin light chain 1
MGI:95589
Synonyms
Ftl, L-ferritin
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45457944-45459884 bp, - strand
From VEGA annotation of GRCm38

  1941 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:79330  Vertebrate Homology Class
1 human; 2 mouse; 8 rat; 1 chimpanzee; 3 rhesus macaque; 4 cattle; 2 dog; 1 western clawed frog

HCOP human homology predictions: FTL
Protein SuperFamily: ferritin
Gene Tree: Ftl1

Human
homologs
FTL, ferritin, light polypeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2512
neXtProt AC: NX_P02792

Human Synonyms: LFTD, NBIA3

Human Chr (Location): 19q13.33; chr19:48965309-48966879 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human FTL

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(1) Transgenic(1)
Incidental mutations (data from APF )
Mutations Annotated to Human Diseases (1)   
Interactions
Ftl1 interacts with 60 markers (Mir22, Mir92-1, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Component cytoplasm, extracellular exosome, ...
Function identical protein binding, iron ion binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (14)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
RT-PCR 2
cDNA source data(38)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(41) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022565 (Evidence)
Ensembl Gene Model ENSMUSG00000050708 (Evidence)
Entrez Gene 14325 (Evidence)
DoTS DT.101123906, DT.101374525, DT.101374656, DT.103576057, DT.40170879, DT.91403229, DT.94222407, DT.94235556, DT.99871270
Consensus CDS Project CCDS39952.1
International Mouse Phenotyping Consortium Status Ftl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022565 VEGA Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
transcript OTTMUST00000054058 VEGA | MGI Sequence Detail 968 Not Applicable 
polypeptide OTTMUSP00000025746 VEGA | MGI Sequence Detail 183 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000007738 ferritin light chain 1
References
(Earliest) J:9732 Beaumont C, et al., Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse. Unambiguous identification of mouse ferritin subunits and in vitro formation of the ferritin shells. J Biol Chem. 1989 May 5;264(13):7498-504
(Latest) J:218500 Fan Y, et al., The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages. Biochim Biophys Acta. 2014 Nov;1843(11):2775-83
All references(42)
Other
accession IDs
MGD-MRK-9885, MGD-MRK-9886, MGD-MRK-9888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory