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Cidec Gene Detail
Summary
  • Symbol
    Cidec
  • Name
    cell death-inducing DFFA-like effector c
  • Synonyms
    CIDE-3, CIDE-3alpha, Fsp27
  • Feature Type
    protein coding gene
  • IDs
    MGI:95585
    NCBI Gene: 14311
Location & Maps
more
  • Sequence Map
    Chr6:113424634-113435760 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11127 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CIDEC, cell death inducing DFFA like effector c
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CIDEC, cell death inducing DFFA like effector c
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIDE3, CIDE-3, FPLD5, FSP27
  • Links
    NCBI Gene ID: 63924
    neXtProt AC: NX_Q96AQ7

  • Chr Location
    3p25.3; chr3:9866710-9880262 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CIDEC associations

Human Disease Mouse Models
       Lipodystrophy, Familial Partial, Type 5; FPLD5   OMIM: 615238
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    29 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    8
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Cidec
Nullizygous mice exhibit leaness, high energy expenditure, improved glucose tolerance, altered brown adipocytes, and multilocular fat droplets with enhanced mitochondrial activity and lipolysis in white adipocytes, and may show resistance to age related and diet-induced obesity and liver steatosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023130 VEGA Gene Model | MGI Sequence Detail 11127 C57BL/6J ±  kb
transcript OTTMUST00000055899 VEGA | MGI Sequence Detail 785 Not Applicable  
polypeptide OTTMUSP00000026813 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    Genomic 1
    cDNA 49
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9879
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:154 Danesch U, et al., Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression. J Biol Chem. 1992 Apr 5;267(10):7185-93
  • Latest
    J:226899 Tanaka N, et al., Adipocyte-specific disruption of fat-specific protein 27 causes hepatosteatosis and insulin resistance in high-fat diet-fed mice. J Biol Chem. 2015 Jan 30;290(5):3092-105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory