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Cidec
Gene Detail
Symbol

Name
ID
Cidec
cell death-inducing DFFA-like effector c
MGI:95585
Synonyms
CIDE-3, CIDE-3alpha, Fsp27
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.76 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:113424634-113435760 bp, - strand
From VEGA annotation of GRCm38

  11127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11128  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CIDEC
Gene Tree: Cidec

Human
homologs
CIDEC, cell death-inducing DFFA-like effector c
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 63924
neXtProt AC: NX_Q96AQ7

Human Synonyms: CIDE3, CIDE-3, FPLD5, FSP27

Human Chr (Location): 3p25.3; chr3:9866710-9880262 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CIDEC

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Spontaneous(1) Targeted(5)
Genomic Mutations involving Cidec (1)
 
Nullizygous mice exhibit leaness, high energy expenditure, improved glucose tolerance, altered brown adipocytes, and multilocular fat droplets with enhanced mitochondrial activity and lipolysis in white adipocytes, and may show resistance to age related and diet-induced obesity and liver steatosis.
 
Interactions
Cidec interacts with 107 markers (Mir17, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic process, execution phase of apoptosis, ...
Component cytosol, endoplasmic reticulum, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cidec ; ZFIN cidec    NEW 
Molecular
reagents
All nucleic(51) Genomic(1) cDNA(49) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023130 (Evidence)
Ensembl Gene Model ENSMUSG00000030278 (Evidence)
Entrez Gene 14311 (Evidence)
UniGene 10026
DFCI TC1580634
DoTS DT.101366042, DT.494107
NIA Mouse Gene Index U041045
PDB 4IKG, 4MAC
Consensus CDS Project CCDS20418.1
International Mouse Phenotyping Consortium Status Cidec
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023130 VEGA Gene Model | MGI Sequence Detail 11127 C57BL/6J ±  kb
transcript OTTMUST00000055899 VEGA | MGI Sequence Detail 785 Not Applicable 
polypeptide OTTMUSP00000026813 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003508 CIDE-N domain
Protein Ontology PR:000005494 cell death activator CIDE-3
References
(Earliest) J:154 Danesch U, et al., Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression. J Biol Chem. 1992 Apr 5;267(10):7185-93
(Latest) J:218409 Zhang X, et al., Regulation of FSP27 protein stability by AMPK and HSC70. Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1047-56
All references(46)
Other
accession IDs
MGD-MRK-9879

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory