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Fshr
Gene Detail
 Symbol
Name
ID
Fshr
follicle stimulating hormone receptor
MGI:95583
Synonyms follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
Feature Type protein coding gene
Genetic Map
Chromosome 17
58.76 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:88985170-89200612 bp, - strand
From Ensembl annotation of GRCm38

  215443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Fshr

Human
homologs
Human Homolog FSHR, follicle stimulating hormone receptor
NCBI Gene ID 2492
neXtProt AC  NX_P23945
Human Synonyms  FSHRO, LGR1, ODG1
Human Chr (Location)  2p21-p16; chr2:48962157-49154527 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FSHR
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component cell surface, endosome, ...
Function follicle-stimulating hormone receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (8)    Tissues (5)    Images (2)
Theiler Stages: 1, 2, 24, 28
Assay TypeResults
RNA in situ 2
RT-PCR 6
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(6) cDNA(5) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032937 (Evidence)
Entrez Gene14309 (Evidence)
UniGene57155
DFCITC1592510
DoTSDT.55217332
NIA Mouse Gene IndexU038152
Consensus CDS ProjectCCDS29026.1
International Mouse Knockout Project StatusFshr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032937 Ensembl Gene Model | MGI Sequence Detail 215443 C57BL/6J ±  kb
transcript ENSMUST00000035701 Ensembl | MGI Sequence Detail 2079 Not Applicable 
polypeptide ENSMUSP00000040477 Ensembl | MGI Sequence Detail 692 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(2217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002272 Follicle-stimulating hormone receptor
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR024635 Gonadotropin hormone receptor, transmembrane domain
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
Protein Ontology PR:000001581 follitropin receptor
References (Earliest) J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
(Latest) J:195723 Migrenne S, et al., Mouse testis development and function are differently regulated by follicle-stimulating hormone receptors signaling during fetal and prepubertal life. PLoS One. 2012;7(12):e53257
All references(86)
Other
accession IDs
MGD-MRK-9876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory