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Fshr Gene Detail
Summary
  • Symbol
    Fshr
  • Name
    follicle stimulating hormone receptor
  • Synonyms
    follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:95583
    NCBI Gene: 14309
Location & Maps
more
  • Sequence Map
    Chr17:88985170-89200612 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      215443 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
    Orthology source: HomoloGene
  • Synonyms
    FSHR1, FSHRO, LGR1, ODG1
  • Links
    NCBI Gene ID: 2492
    neXtProt AC: NX_P23945

  • Chr Location
    2p21-p16; chr2:48866435-49154527 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human FSHR associations

Human Disease Mouse Models
       Ovarian Dysgenesis 1; ODG1   OMIM: 233300
Ovarian Hyperstimulation Syndrome; OHSS   OMIM: 608115
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    153 phenotypes from 8 alleles in 7 genetic backgrounds
    2 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Targeted
    4
  • Transgenic
    5
  • Incidental Mutations
Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032937 Ensembl Gene Model | MGI Sequence Detail 215443 C57BL/6J ±  kb
transcript ENSMUST00000035701 Ensembl | MGI Sequence Detail 2079 Not Applicable  
polypeptide ENSMUSP00000040477 Ensembl | MGI Sequence Detail 692 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2212 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001581 follitropin receptor
  • InterPro Domains
    IPR002272 Follicle stimulating hormone receptor
    IPR002131 Glycoprotein hormone receptor family
    IPR024635 Gonadotropin hormone receptor, transmembrane domain
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR026906 Leucine rich repeat 5
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
Molecular
Reagents
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  • All nucleic 14
    Genomic 6
    cDNA 5
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9876
References
more
  • Summaries
    All 88
    Developmental Gene Expression 8
    Gene Ontology 28
    Phenotypes 47
  • Earliest
    J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
  • Latest
    J:226139 Laissue P, Aetiological coding sequence variants in non-syndromic premature ovarian failure: From genetic linkage analysis to next generation sequencing. Mol Cell Endocrinol. 2015 Aug 15;411:243-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory