Fshr
Gene Detail

Symbol Name ID

Fshr follicle stimulating hormone receptor MGI:95583

Synonyms

follicle-stimulating hormone receptor, Follitropin receptor, FSH-R

Feature Type

protein coding gene

Genetic Map

Chromosome 17

58.76 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:88985170-89200612 bp, - strand From Ensembl annotation of GRCm38   215443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Fshr

Human homologs

Human Homolog		FSHR, follicle stimulating hormone receptor
NCBI Gene ID		2492
neXtProt AC		NX_P23945
Human Synonyms		FSHRO, LGR1, ODG1
Human Chr (Location)		2p21-p16; chr2:49189296-49381666 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FSHR

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, ...
Component	cell surface, endosome, ...
Function	follicle-stimulating hormone receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (8)    Tissues (5)    Images (2)
Theiler Stages: 1, 2, 24, 28

Assay Type	Results
RNA in situ	2
RT-PCR	6

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(6) cDNA(5) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032937 (Evidence)
Entrez Gene	14309 (Evidence)
UniGene	57155
DFCI	TC1592510
DoTS	DT.55217332
NIA Mouse Gene Index	U038152
Consensus CDS Project	CCDS29026.1
International Mouse Knockout Project Status	Fshr

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032937	Ensembl Gene Model | MGI Sequence Detail	215443	C57BL/6J
transcript	ENSMUST00000035701	Ensembl | MGI Sequence Detail	2079	Not Applicable
polypeptide	ENSMUSP00000040477	Ensembl | MGI Sequence Detail	692	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(340 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002272	Follicle-stimulating hormone receptor
InterPro	IPR002131	Glycoprotein hormone receptor
InterPro	IPR024635	Gonadotropin hormone receptor, transmembrane domain
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
Protein Ontology	PR:000001581	follitropin receptor

References

(Earliest) J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
(Latest) J:189895 Zhu LL, et al., Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14574-9
All references(85)

Other accession IDs

MGD-MRK-9876