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Fshr
Gene Detail
Symbol

Name
ID
Fshr
follicle stimulating hormone receptor
MGI:95583
Synonyms
follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
Feature Type
protein coding gene
Genetic Map
Chromosome 17
58.76 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:88985170-89200612 bp, - strand
From Ensembl annotation of GRCm38

  215443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FSHR
Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Fshr

Human
homologs
FSHR, follicle stimulating hormone receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2492
neXtProt AC: NX_P23945

Human Synonyms: FSHRO, LGR1, ODG1

Human Chr (Location): 2p21-p16; chr2:48866435-49154527 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FSHR

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.
 
Phenotype Images(2)
Interactions
Fshr interacts with 3 markers (Mir409, Mir503, Mir3572)
Expression
Literature Summary: (8 records)
Data Summary: Results (8)    Tissues (5)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 6
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fshr ; ZFIN fshr    NEW 
Molecular
reagents
All nucleic(14) Genomic(6) cDNA(5) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032937 (Evidence)
Entrez Gene 14309 (Evidence)
UniGene 57155
DFCI TC1592510
DoTS DT.55217332
NIA Mouse Gene Index U038152
Consensus CDS Project CCDS29026.1
International Mouse Phenotyping Consortium Status Fshr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032937 Ensembl Gene Model | MGI Sequence Detail 215443 C57BL/6J ±  kb
transcript ENSMUST00000035701 Ensembl | MGI Sequence Detail 2079 Not Applicable 
polypeptide ENSMUSP00000040477 Ensembl | MGI Sequence Detail 692 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(2217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002272 Follicle-stimulating hormone receptor
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR024635 Gonadotropin hormone receptor, transmembrane domain
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
Protein Ontology PR:000001581 follitropin receptor
References
(Earliest) J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
(Latest) J:215750 Stilley JA, et al., FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice. Biol Reprod. 2014 Sep;91(3):74
All references(88)
Other
accession IDs
MGD-MRK-9876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory