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Fshr Gene Detail
Summary
  • Symbol
    Fshr
  • Name
    follicle stimulating hormone receptor
  • Synonyms
    follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:95583
    NCBI Gene: 14309
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:88985170-89200612 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      215443 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 58.76 cM, cytoband E5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FSHR1, FSHRO, LGR1, ODG1
  • Links
    NCBI Gene ID: 2492
    neXtProt AC: NX_P23945
    UniProt: P23945

  • Chr Location
    2p16.3; chr2:48953161-49154527 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human FSHR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    154 phenotypes from 8 alleles in 7 genetic backgrounds
    2 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032937 Ensembl Gene Model | MGI Sequence Detail 215443 C57BL/6J ±  kb
    transcript ENSMUST00000035701 Ensembl | MGI Sequence Detail 2079 Not Applicable  
    polypeptide ENSMUSP00000040477 Ensembl | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2212 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 7
      cDNA 5
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9876
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 10
      Gene Ontology 28
      Phenotypes 48
    • Earliest
      J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
    • Latest
      J:262869 Oduwole OO, et al., Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis. J Clin Invest. 2018 May 1;128(5):1787-1792

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory