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Fshr Gene Detail
Summary
  • Symbol
    Fshr
  • Name
    follicle stimulating hormone receptor
  • Synonyms
    follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:95583
    NCBI Gene: 14309
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:88985170-89200612 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 58.76 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2212 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95583
protein coding gene Chr17:88984952-89200675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024114
protein coding gene Chr17:92503961-92730974 (-)
A/J MGP_AJ_G0024074
protein coding gene Chr17:89510660-89738147 (-)
AKR/J MGP_AKRJ_G0024043
protein coding gene Chr17:91008857-91226846 (-)
BALB/cJ MGP_BALBcJ_G0024075
protein coding gene Chr17:89334558-89550567 (-)
C3H/HeJ MGP_C3HHeJ_G0023840
protein coding gene Chr17:91913574-92131326 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024520
protein coding gene Chr17:95730831-95957732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021958
protein coding gene Chr17:84561916-84763428 (-)
CAST/EiJ MGP_CASTEiJ_G0023319
protein coding gene Chr17:92781944-92999897 (-)
CBA/J MGP_CBAJ_G0023813
protein coding gene Chr17:99746990-99977967 (-)
DBA/2J MGP_DBA2J_G0023942
protein coding gene Chr17:87892679-88105200 (-)
FVB/NJ MGP_FVBNJ_G0023908
protein coding gene Chr17:87439105-87651824 (-)
LP/J MGP_LPJ_G0024026
protein coding gene Chr17:93286106-93509070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023936
protein coding gene Chr17:99510923-99740202 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024565
protein coding gene Chr17:91560462-91787735 (-)
PWK/PhJ MGP_PWKPhJ_G0023064
protein coding gene Chr17:87591748-87807459 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022875
protein coding gene Chr17:88297349-88494643 (-)
WSB/EiJ MGP_WSBEiJ_G0023385
protein coding gene Chr17:92426183-92640966 (-)



Homology
more
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FSHR1, FSHRO, LGR1, ODG1
  • Links
    NCBI Gene ID: 2492
    neXtProt AC: NX_P23945
    UniProt: P23945

  • Chr Location
    2p16.3; chr2:48953161-49154527 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human FSHR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    154 phenotypes from 8 alleles in 7 genetic backgrounds
    2 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032937 Ensembl Gene Model | MGI Sequence Detail 215443 C57BL/6J ±  kb
    transcript ENSMUST00000035701 Ensembl | MGI Sequence Detail 2079 Not Applicable  
    polypeptide ENSMUSP00000040477 Ensembl | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 7
      cDNA 5
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9876
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 10
      Gene Ontology 29
      Phenotypes 49
    • Earliest
      J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
    • Latest
      J:262869 Oduwole OO, et al., Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis. J Clin Invest. 2018 May 1;128(5):1787-1792

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory