About   Help   FAQ
Fshb
Gene Detail
Symbol

Name
ID
Fshb
follicle stimulating hormone beta
MGI:95582
Synonyms
FSH, Fshbeta
Feature Type
protein coding gene
Genetic Map
Chromosome 2
56.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr2:107056140-107059656 bp, - strand
From VEGA annotation of GRCm38

  3517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FSHB
Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Fshb

Human
homologs
FSHB, follicle stimulating hormone, beta polypeptide
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2488
neXtProt AC: NX_P01225

Human Synonyms: HH24

Human Chr (Location): 11p13; chr11:30230688-30235277 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FSHB

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Females homozygous for a targeted null mutation are sterile with a preantral block in folliculogenesis. Mutant males have small testes and reduced Sertoli and germ cell numbers, but are fertile.
 
Interactions
Fshb interacts with 174 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (36 records)
Data Summary: Results (19)    Tissues (13)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 13
RT-PCR 2
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN fshb    NEW 
Molecular
reagents
All nucleic(60) Genomic(3) cDNA(55) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015038 (Evidence)
Ensembl Gene Model ENSMUSG00000027120 (Evidence)
Entrez Gene 14308 (Evidence)
UniGene 249525
DFCI TC1580931
DoTS DT.55239107
NIA Mouse Gene Index U023130
Consensus CDS Project CCDS16504.1
International Mouse Phenotyping Consortium Status Fshb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015038 VEGA Gene Model | MGI Sequence Detail 3517 C57BL/6J ±  kb
transcript OTTMUST00000035718 VEGA | MGI Sequence Detail 1600 Not Applicable 
polypeptide OTTMUSP00000016012 VEGA | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(4) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR001545 Gonadotropin, beta subunit
InterPro IPR018245 Gonadotropin, beta subunit, conserved site
Protein Ontology PR:000007682 follitropin subunit beta
References
(Earliest) J:4815 Glaser T, et al., A fine structure deletion map of chromosome 11p. Cytogenet Cell Genet. 1985;40:643
(Latest) J:218295 Mortensen AH, et al., Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
All references(125)
Other
accession IDs
MGD-MRK-9875

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory