Fshb
Gene Detail

Symbol Name ID

Fshb follicle stimulating hormone beta MGI:95582

Synonyms

FSH, Fshbeta

Feature Type

protein coding gene

Genetic Map

Chromosome 2

56.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr2:107056140-107059656 bp, - strand From VEGA annotation of GRCm38   3517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Fshb

Human homologs

Human Homolog		FSHB, follicle stimulating hormone, beta polypeptide
NCBI Gene ID		2488
neXtProt AC		NX_P01225
Human Chr (Location)		11p13; chr11:30252563-30256824 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FSHB

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Females homozygous for a targeted null mutation are sterile with a preantral block in folliculogenesis. Mutant males have small testes and reduced Sertoli and germ cell numbers, but are fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	follicle-stimulating hormone signaling pathway, ovarian follicle development, ...
Component	cytoplasm, extracellular region
Function	hormone activity

External Resources: FuncBase

Expression

Literature Summary: (29 records)
Data Summary: Results (19)    Tissues (12)    Images (1)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	13
RT-PCR	2

cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(3) cDNA(55) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015038 (Evidence)
Ensembl Gene Model	ENSMUSG00000027120 (Evidence)
Entrez Gene	14308 (Evidence)
UniGene	249525
DFCI	TC1580931
DoTS	DT.55239107
NIA Mouse Gene Index	U023130
Consensus CDS Project	CCDS16504.1
International Mouse Knockout Project Status	Fshb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015038	VEGA Gene Model | MGI Sequence Detail	3517	C57BL/6J
transcript	OTTMUST00000035718	VEGA | MGI Sequence Detail	1600	Not Applicable
polypeptide	OTTMUSP00000016012	VEGA | MGI Sequence Detail	130	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006208	Cystine knot
InterPro	IPR001545	Gonadotropin, beta subunit
InterPro	IPR018245	Gonadotropin, beta subunit, conserved site
Protein Ontology	PR:000007682	follitropin subunit beta

References

(Earliest) J:4815 Glaser T, et al., A fine structure deletion map of chromosome 11p. Cytogenet Cell Genet. 1985;40:643
(Latest) J:192381 Demeestere I, et al., Follicle-stimulating hormone accelerates mouse oocyte development in vivo. Biol Reprod. 2012 Jul;87(1):3, 1-11
All references(117)

Other accession IDs

MGD-MRK-9875