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Fshb
Gene Detail
 Symbol
Name
ID
Fshb
follicle stimulating hormone beta
MGI:95582
Synonyms FSH, Fshbeta
Feature Type protein coding gene
Genetic Map
Chromosome 2
56.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)
Sequence Map
Chr2:107056140-107059656 bp, - strand
From VEGA annotation of GRCm38

  3517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pituitary glycoprotein hormone beta chain
Gene Tree: Fshb

Human
homologs
Human Homolog FSHB, follicle stimulating hormone, beta polypeptide
NCBI Gene ID 2488
neXtProt AC  NX_P01225
Human Chr (Location)  11p13; chr11:30231016-30235277 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FSHB
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Females homozygous for a targeted null mutation are sterile with a preantral block in folliculogenesis. Mutant males have small testes and reduced Sertoli and germ cell numbers, but are fertile.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process follicle-stimulating hormone signaling pathway, ovarian follicle development, ...
Component cytoplasm, extracellular region, ...
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (19)    Tissues (12)    Images (1)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 13
RT-PCR 2
cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) Genomic(3) cDNA(55) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015038 (Evidence)
Ensembl Gene ModelENSMUSG00000027120 (Evidence)
Entrez Gene14308 (Evidence)
UniGene249525
DFCITC1580931
DoTSDT.55239107
NIA Mouse Gene IndexU023130
Consensus CDS ProjectCCDS16504.1
International Mouse Knockout Project StatusFshb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015038 VEGA Gene Model | MGI Sequence Detail 3517 C57BL/6J ±  kb
transcript OTTMUST00000035718 VEGA | MGI Sequence Detail 1600 Not Applicable 
polypeptide OTTMUSP00000016012 VEGA | MGI Sequence Detail 130 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms RFLP(4) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR001545 Gonadotropin, beta subunit
InterPro IPR018245 Gonadotropin, beta subunit, conserved site
Protein Ontology PR:000007682 follitropin subunit beta
References (Earliest) J:4815 Glaser T, et al., A fine structure deletion map of chromosome 11p. Cytogenet Cell Genet. 1985;40:643
(Latest) J:208630 Wang H, et al., Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5735-40
All references(124)
Other
accession IDs
MGD-MRK-9875

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory