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Fosb
Gene Detail
 Symbol
Name
ID
Fosb
FBJ osteosarcoma oncogene B
MGI:95575
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.56 cM, cytoband A2-B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:19302721-19310045 bp, - strand
From Ensembl annotation of GRCm38

  7325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31403  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: fos transforming protein
Gene Tree: Fosb

Human
homologs
Human Homolog FOSB, FBJ murine osteosarcoma viral oncogene homolog B
NCBI Gene ID 2354
neXtProt AC  NX_P53539
Human Synonyms  AP-1, G0S3, GOS3, GOSB
Human Chr (Location)  19q13.32; chr19:45467995-45475179 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show impaired nurturing behavior, altered behavioral tolerance to repeated motor seizures, reduced NMDA-mediated synaptic currents, and altered paradoxical sleep. Aging mice homozygous for another null allele may exhibit occasional tonic-clonic or generalized seizures.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cellular response to calcium ion, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (159)    Tissues (152)    Images (4)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 138
Western blot 6
RT-PCR 15
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003545 (Evidence)
Entrez Gene14282 (Evidence)
UniGene248335
DoTSDT.101395135, DT.94303090
NIA Mouse Gene IndexU028220
Consensus CDS ProjectCCDS20897.1
International Mouse Knockout Project StatusFosb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003545 Ensembl Gene Model | MGI Sequence Detail 7325 C57BL/6J ±  kb
transcript ENSMUST00000003640 Ensembl | MGI Sequence Detail 3751 Not Applicable 
polypeptide ENSMUSP00000003640 Ensembl | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR000837 Fos transforming protein
Protein Ontology PR:000007598 protein fosB
References (Earliest) J:15672 Zerial M, et al., The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989 Mar;8(3):805-13
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(59)
Other
accession IDs
MGD-MRK-9867

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory