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Fosb
Gene Detail
Symbol

Name
ID
Fosb
FBJ osteosarcoma oncogene B
MGI:95575
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.56 cM, cytoband A2-B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:19302721-19310045 bp, - strand
From Ensembl annotation of GRCm38

  7325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31403  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOSB
Protein SuperFamily: fos transforming protein
Gene Tree: Fosb

Human
homologs
FOSB, FBJ murine osteosarcoma viral oncogene homolog B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2354
neXtProt AC: NX_P53539

Human Synonyms: AP-1, G0S3, GOS3, GOSB

Human Chr (Location): 19q13.32; chr19:45467995-45475179 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a null allele show impaired nurturing behavior, altered behavioral tolerance to repeated motor seizures, reduced NMDA-mediated synaptic currents, and altered paradoxical sleep. Aging mice homozygous for another null allele may exhibit occasional tonic-clonic or generalized seizures.
 
Interactions
Fosb interacts with 290 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cellular response to calcium ion, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (152)    Tissues (148)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
Western blot 6
RT-PCR 8
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000003545 (Evidence)
Entrez Gene 14282 (Evidence)
UniGene 248335
DoTS DT.101395135, DT.94303090
NIA Mouse Gene Index U028220
Consensus CDS Project CCDS20897.1
International Mouse Phenotyping Consortium Status Fosb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003545 Ensembl Gene Model | MGI Sequence Detail 7325 C57BL/6J ±  kb
transcript ENSMUST00000003640 Ensembl | MGI Sequence Detail 3751 Not Applicable 
polypeptide ENSMUSP00000003640 Ensembl | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR000837 Fos transforming protein
Protein Ontology PR:000007598 protein fosB
References
(Earliest) J:15672 Zerial M, et al., The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989 Mar;8(3):805-13
(Latest) J:219418 Heller EA, et al., Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nat Neurosci. 2014 Dec;17(12):1720-7
All references(65)
Other
accession IDs
MGD-MRK-9867

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory