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Fosb Gene Detail
Summary
  • Symbol
    Fosb
  • Name
    FBJ osteosarcoma oncogene B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95575
    NCBI Gene: 14282
  • Gene Overview
    MyGene.info: FOSB
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:19302696-19310051 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7356 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.56 cM, cytoband A2-B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOSB, FosB proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOSB, FosB proto-oncogene, AP-1 transcription factor subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP-1, G0S3, GOS3, GOSB
  • Links
    NCBI Gene ID: 2354
    neXtProt AC: NX_P53539
    UniProt: P53539

  • Chr Location
    19q13.32; chr19:45467995-45475179 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show impaired nurturing behavior, altered behavioral tolerance to repeated motor seizures, reduced NMDA-mediated synaptic currents, and altered paradoxical sleep. Aging mice homozygous for another null allele may exhibit occasional tonic-clonic or generalized seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059145 VEGA Gene Model | MGI Sequence Detail 7356 C57BL/6J ±  kb
    transcript OTTMUST00000145066 VEGA | MGI Sequence Detail 3782 Not Applicable  
    polypeptide OTTMUSP00000075582 VEGA | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      94 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 17
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9867
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 13
      Gene Ontology 6
      Phenotypes 37
    • Earliest
      J:15672 Zerial M, et al., The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989 Mar;8(3):805-13
    • Latest
      J:259582 You JC, et al., Genome-wide profiling reveals functional diversification of FosB gene targets in the hippocampus of an Alzheimer's disease mouse model. PLoS One. 2018;13(2):e0192508

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory