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Fosb Gene Detail
Summary
  • Symbol
    Fosb
  • Name
    FBJ osteosarcoma oncogene B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95575
    NCBI Gene: 14282
  • Gene Overview
    MyGene.info: FOSB
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19302696-19310051 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.56 cM, cytoband A2-B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95575
protein coding gene Chr7:19302696-19310226 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031770
protein coding gene Chr7:17297480-17304801 (-)
A/J MGP_AJ_G0031746
protein coding gene Chr7:16945672-16952993 (-)
AKR/J MGP_AKRJ_G0031672
protein coding gene Chr7:17408501-17416186 (-)
BALB/cJ MGP_BALBcJ_G0031751
protein coding gene Chr7:17148550-17155874 (-)
C3H/HeJ MGP_C3HHeJ_G0031473
protein coding gene Chr7:17676358-17683679 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032217
protein coding gene Chr7:18160456-18167782 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029283
protein coding gene Chr7:18593884-18601237 (-)
CAST/EiJ MGP_CASTEiJ_G0030816
protein coding gene Chr7:14077376-14084700 (-)
CBA/J MGP_CBAJ_G0031435
protein coding gene Chr7:18832952-18840273 (-)
DBA/2J MGP_DBA2J_G0031590
protein coding gene Chr7:16887867-16895406 (-)
FVB/NJ MGP_FVBNJ_G0031542
protein coding gene Chr7:16749414-16756736 (-)
LP/J MGP_LPJ_G0031673
protein coding gene Chr7:17613808-17621129 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031578
protein coding gene Chr7:18682801-18690122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032245
protein coding gene Chr7:17016145-17023468 (-)
PWK/PhJ MGP_PWKPhJ_G0030540
protein coding gene Chr7:13977044-13984450 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030367
protein coding gene Chr7:11732315-11739650 (-)
WSB/EiJ MGP_WSBEiJ_G0030916
protein coding gene Chr7:17235501-17242835 (-)



Homology
more
  • Human Ortholog
    FOSB, FosB proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FOSB, FosB proto-oncogene, AP-1 transcription factor subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AP-1, G0S3, GOS3, GOSB
  • Links
    NCBI Gene ID: 2354
    neXtProt AC: NX_P53539
    UniProt: P53539

  • Chr Location
    19q13.32; chr19:45467995-45475179 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show impaired nurturing behavior, altered behavioral tolerance to repeated motor seizures, reduced NMDA-mediated synaptic currents, and altered paradoxical sleep. Aging mice homozygous for another null allele may exhibit occasional tonic-clonic or generalized seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003545 Ensembl Gene Model | MGI Sequence Detail 7356 C57BL/6J ±  kb
    transcript ENSMUST00000003640 Ensembl | MGI Sequence Detail 3782 Not Applicable  
    polypeptide ENSMUSP00000003640 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9867
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 13
      Gene Ontology 8
      Phenotypes 38
    • Earliest
      J:15672 Zerial M, et al., The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989 Mar;8(3):805-13
    • Latest
      J:259582 You JC, et al., Genome-wide profiling reveals functional diversification of FosB gene targets in the hippocampus of an Alzheimer's disease mouse model. PLoS One. 2018;13(2):e0192508

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory