About   Help   FAQ
Folr1
Gene Detail
 Symbol
Name
ID
Folr1
folate receptor 1 (adult)
MGI:95568
Synonyms FBP1, folate-binding protein 1, folate receptor [a], Folbp1, Folbp-1
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:101858331-101870788 bp, - strand
From VEGA annotation of GRCm38

  12458 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: folate-binding protein
Gene Tree: Folr1

Human
homologs
Human Homolog FOLR1, folate receptor 1 (adult)
NCBI Gene ID 2348
neXtProt AC  NX_P15328
Human Synonyms  FBP, FOLR
Human Chr (Location)  11q13.3-q14.1; chr11:72189558-72196323 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FOLR1
Alleles
and
phenotypes
All alleles(359) : Targeted(3) Gene trapped(356)
 
Embryos homozygous for a knock-out allele are growth retarded and malformed, show multiple developmental anomalies, including neural and craniofacial defects, and die by E10. Folate supplementation of pregnant dams reduces embryonic mortality and improves many of the adverse developmental effects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process folic acid metabolic process, folic acid transport, ...
Component anchored component of external side of plasma membrane, anchored component of membrane, ...
Function folic acid binding, folic acid transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (226)    Tissues (148)    Images (27)
Theiler Stages: 12, 14, 16, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 215
RNase protection 11
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022222 (Evidence)
Ensembl Gene ModelENSMUSG00000001827 (Evidence)
Entrez Gene14275 (Evidence)
DFCITC1577359, TC1664564, TC1668506
DoTSDT.101189550, DT.101366044, DT.101372961, DT.101373102, DT.110990581, DT.535729, DT.91447910, DT.94304303
NIA Mouse Gene IndexU028931
Consensus CDS ProjectCCDS21517.1
International Mouse Knockout Project StatusFolr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022222 VEGA Gene Model | MGI Sequence Detail 12458 C57BL/6J ±  kb
transcript OTTMUST00000052825 VEGA | MGI Sequence Detail 960 Not Applicable 
polypeptide OTTMUSP00000025095 VEGA | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(141) RefSeq(30) UniProt(11)
Polymorphisms SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004269 Folate receptor
InterPro IPR018143 Folate receptor-like
Protein Ontology PR:000007594 folate receptor alpha
References (Earliest) J:11440 Brigle KE, et al., Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement. J Biol Chem. 1991 Sep 15;266(26):17243-9
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(63)
Other
accession IDs
MGD-MRK-9854, MGD-MRK-9856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory