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Folr1 Gene Detail
Summary
  • Symbol
    Folr1
  • Name
    folate receptor 1 (adult)
  • Synonyms
    FBP1, folate-binding protein 1, folate receptor [a], Folbp1, Folbp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95568
    NCBI Gene: 14275
  • Gene Overview
    MyGene.info: FOLR1
Location & Maps
more
  • Sequence Map
    Chr7:101858331-101870788 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12458 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOLR1, folate receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOLR1, folate receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBP, FOLR
  • Links
    NCBI Gene ID: 2348
    neXtProt AC: NX_P15328

  • Chr Location
    11q13.4; chr11:72189558-72196323 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FOLR1 associations

Human Disease Mouse Models
       Neurodegeneration Due to Cerebral Folate Transport Deficiency   OMIM: 613068
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    362
  • Chemically induced (other)
    1
  • Gene trapped
    356
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Folr1
  • Incidental Mutations
Embryos homozygous for a knock-out allele are growth retarded and malformed, show multiple developmental anomalies, including neural and craniofacial defects, and die by E10. Folate supplementation of pregnant dams reduces embryonic mortality and improves many of the adverse developmental effects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022222 VEGA Gene Model | MGI Sequence Detail 12458 C57BL/6J ±  kb
transcript OTTMUST00000052825 VEGA | MGI Sequence Detail 960 Not Applicable  
polypeptide OTTMUSP00000025095 VEGA | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    124 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-9854, MGD-MRK-9856
References
more
  • Summaries
    All 66
    Developmental Gene Expression 13
    Gene Ontology 8
    Phenotypes 32
  • Earliest
    J:11440 Brigle KE, et al., Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement. J Biol Chem. 1991 Sep 15;266(26):17243-9
  • Latest
    J:214694 Kur E, et al., LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory