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Folr1 Gene Detail
Summary
  • Symbol
    Folr1
  • Name
    folate receptor 1 (adult)
  • Synonyms
    FBP1, folate-binding protein 1, folate receptor [a], Folbp1, Folbp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95568
    NCBI Gene: 14275
  • Gene Overview
    MyGene.info: FOLR1
  • Alliance
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101858331-101870788 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95568
protein coding gene Chr7:101858331-101870788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032590
protein coding gene Chr7:104870039-104884081 (-)
A/J MGP_AJ_G0032566
protein coding gene Chr7:102201541-102213934 (-)
AKR/J MGP_AKRJ_G0032502
protein coding gene Chr7:104647503-104660100 (-)
BALB/cJ MGP_BALBcJ_G0032577
protein coding gene Chr7:101900890-101913390 (-)
C3H/HeJ MGP_C3HHeJ_G0032291
protein coding gene Chr7:105020855-105033567 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033074
protein coding gene Chr7:108820929-108835940 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030068
protein coding gene Chr7:104557405-104571872 (-)
CAST/EiJ MGP_CASTEiJ_G0031617
protein coding gene Chr7:96574999-96587353 (-)
CBA/J MGP_CBAJ_G0032257
protein coding gene Chr7:112585904-112600583 (-)
DBA/2J MGP_DBA2J_G0032409
protein coding gene Chr7:100529397-100541838 (-)
FVB/NJ MGP_FVBNJ_G0032365
protein coding gene Chr7:100310859-100323299 (-)
LP/J MGP_LPJ_G0032498
protein coding gene Chr7:106187919-106200321 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032399
protein coding gene Chr7:113923846-113936832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033096
protein coding gene Chr7:103914896-103929333 (-)
PWK/PhJ MGP_PWKPhJ_G0031335
protein coding gene Chr7:93640731-93653627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031179
protein coding gene Chr7:91200567-91216435 (-)
WSB/EiJ MGP_WSBEiJ_G0031734
protein coding gene Chr7:104601965-104614368 (-)



Homology
more
  • Human Ortholog
    FOLR1, folate receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOLR1, folate receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBP, FOLR
  • Links
    NCBI Gene ID: 2348
    neXtProt AC: NX_P15328
    UniProt: P15328

  • Chr Location
    11q13.4; chr11:72189558-72196323 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FOLR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 2 alleles in 3 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are growth retarded and malformed, show multiple developmental anomalies, including neural and craniofacial defects, and die by E10. Folate supplementation of pregnant dams reduces embryonic mortality and improves many of the adverse developmental effects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14275 NCBI Gene Model | MGI Sequence Detail 12458 C57BL/6J ±  kb
    transcript NM_001252552 RefSeq | MGI Sequence Detail 1411 Not Specified  
    polypeptide P35846 UniProt | EBI | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-9854, MGD-MRK-9856
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 14
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:244712 Navarro N, et al., Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?. G3 (Bethesda). 2016 May 03;6(5):1153-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/07/2019
    MGI 6.14
    The Jackson Laboratory