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Flt3l
Gene Detail
Symbol

Name
ID
Flt3l
FMS-like tyrosine kinase 3 ligand
MGI:95560
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.14 cM, cytoband B2-C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45131188-45136432 bp, - strand
From VEGA annotation of GRCm38

  5245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: FLT3LG
Protein SuperFamily: Fms-related tyrosine kinase 3 ligand/SL cytokine
Gene Tree: Flt3l

Human
homologs
FLT3LG, fms-related tyrosine kinase 3 ligand
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2323
neXtProt AC: NX_P49771

Human Synonyms: FL, FLT3L

Human Chr (Location): 19q13.3; chr19:49474172-49486234 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable, fertile and healthy but exhibit reduced cellularity in a number of hematopoietic tissues, reduced numbers of myeloid and lymphoid progenitors in the bone marrow, and reduced numbers of dendritic cells and natural killer cells in the lymphoid organs.
 
Interactions
Flt3l interacts with 65 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process embryonic hemopoiesis, lymphocyte differentiation, ...
Component cell surface, extracellular region, ...
Function cytokine activity, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (61)    Tissues (43)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
Northern blot 11
RT-PCR 7
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(3) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033411 (Evidence)
Ensembl Gene Model ENSMUSG00000089989 (Evidence)
Entrez Gene 14256 (Evidence)
UniGene 1658
DFCI TC1586549, TC1595577, TC1612838, TC1629619
DoTS DT.40145610, DT.60101971, DT.91337531, DT.94295950
NIA Mouse Gene Index U028517
Consensus CDS Project CCDS39948.1
International Mouse Phenotyping Consortium Status Flt3l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033411 VEGA Gene Model | MGI Sequence Detail 5245 C57BL/6J ±  kb
transcript OTTMUST00000083899 VEGA | MGI Sequence Detail 834 Not Applicable 
polypeptide OTTMUSP00000045138 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(29) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004213 Flt3 ligand
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
Protein Ontology PR:000007564 fms-related tyrosine kinase 3 ligand
References
(Earliest) J:16458 Lyman SD, et al., Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell. 1993 Dec 17;75(6):1157-67
(Latest) J:220361 Evrard M, et al., Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopy. J Leukoc Biol. 2015 Mar;97(3):611-9
All references(105)
Other
accession IDs
MGD-MRK-9838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory