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Flt3l
Gene Detail
Symbol

Name
ID
Flt3l
FMS-like tyrosine kinase 3 ligand
MGI:95560
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.14 cM, cytoband B2-C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45131188-45136432 bp, - strand
From VEGA annotation of GRCm38

  5245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48021  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Fms-related tyrosine kinase 3 ligand/SL cytokine
Gene Tree: Flt3l

Human
homologs
Human Homolog FLT3LG, fms-related tyrosine kinase 3 ligand
NCBI Gene ID 2323
neXtProt AC  NX_P49771
Human Synonyms  FL, FLT3L
Human Chr (Location)  19q13.3; chr19:49474201-49486234 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable, fertile and healthy but exhibit reduced cellularity in a number of hematopoietic tissues, reduced numbers of myeloid and lymphoid progenitors in the bone marrow, and reduced numbers of dendritic cells and natural killer cells in the lymphoid organs.
 
Interactions
Flt3l interacts with 65 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process embryonic hemopoiesis, lymphocyte differentiation, ...
Component cell surface, extracellular region, ...
Function cytokine activity, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (61)    Tissues (43)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
Northern blot 11
RT-PCR 7
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(3) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033411 (Evidence)
Ensembl Gene ModelENSMUSG00000089989 (Evidence)
Entrez Gene14256 (Evidence)
UniGene1658
DFCITC1586549, TC1595577, TC1612838, TC1629619
DoTSDT.40145610, DT.60101971, DT.91337531, DT.94295950
NIA Mouse Gene IndexU028517
Consensus CDS ProjectCCDS39948.1
International Mouse Knockout Project StatusFlt3l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033411 VEGA Gene Model | MGI Sequence Detail 5245 C57BL/6J ±  kb
transcript OTTMUST00000083899 VEGA | MGI Sequence Detail 834 Not Applicable 
polypeptide OTTMUSP00000045138 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(23) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004213 Flt3 ligand
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
Protein Ontology PR:000007564 fms-related tyrosine kinase 3 ligand
References
(Earliest) J:16458 Lyman SD, et al., Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell. 1993 Dec 17;75(6):1157-67
(Latest) J:213070 Busch M, et al., Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PLoS One. 2014;9(2):e88452
All references(103)
Other
accession IDs
MGD-MRK-9838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory