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Fkbp4
Gene Detail
Symbol

Name
ID
Fkbp4
FK506 binding protein 4
MGI:95543
Synonyms
FKBP52, FKBP-52
Feature Type
protein coding gene
Genetic Map
Chromosome 6
63.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:128429735-128438677 bp, - strand
From VEGA annotation of GRCm38

  8943 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: FK506-binding protein 5
Gene Tree: Fkbp4

Human
homologs
Human Homolog FKBP4, FK506 binding protein 4, 59kDa
NCBI Gene ID 2288
neXtProt AC  NX_Q02790
Human Synonyms  FKBP51, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase
Human Chr (Location)  12p13.33; chr12:2794942-2805423 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null males show reproductive tissue defects consistent with androgen insensitivity such as ambiguous external genitalia, dysgenic prostate, malformed seminal gland and cryptorchism. Males also exhibit hypospadia and infertility. Females are sterile due to failure of implantation.
 
Human Diseases Modeled Using Mouse Fkbp4 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Fkbp4 interacts with 210 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process androgen receptor signaling pathway, chaperone-mediated protein folding, ...
Component axonal growth cone, cytoplasm, ...
Function ATP binding, copper-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000024637 (Evidence)
Ensembl Gene ModelENSMUSG00000030357 (Evidence)
Entrez Gene14228 (Evidence)
DFCITC1573089, TC1617208
DoTSDT.101124371, DT.101136380, DT.101709961, DT.537018, DT.97386313
NIA Mouse Gene IndexU027899
EC5.2.1.8
Consensus CDS ProjectCCDS20573.1
International Mouse Knockout Project StatusFkbp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024637 VEGA Gene Model | MGI Sequence Detail 8943 C57BL/6J ±  kb
transcript OTTMUST00000060562 VEGA | MGI Sequence Detail 2217 Not Applicable 
polypeptide OTTMUSP00000029542 VEGA | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023114 Elongated TPR repeat-containing domain
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000007540 peptidyl-prolyl cis-trans isomerase FKBP4
References
(Earliest) J:10145 Kuhner MK, et al., DNA sequences of mouse H-2 and Qa genes. Immunogenetics. 1989;30(6):458-64
(Latest) J:203921 Blair LJ, et al., Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest. 2013 Oct 1;123(10):4158-69
All references(56)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-9812, MGI:2141664, MGI:2147626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory