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Fkbp4 Gene Detail
Summary
  • Symbol
    Fkbp4
  • Name
    FK506 binding protein 4
  • Synonyms
    FKBP52, FKBP-52
  • Feature Type
    protein coding gene
  • IDs
    MGI:95543
    NCBI Gene: 14228
  • Gene Overview
    MyGene.info: FKBP4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:128429735-128438677 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8943 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.00 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FKBP4, FK506 binding protein 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FKBP4, FK506 binding protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKBP51, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase
  • Links
    NCBI Gene ID: 2288
    neXtProt AC: NX_Q02790
    UniProt: Q02790

  • Chr Location
    12p13.33; chr12:2794942-2805423 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fkbp4 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null males show reproductive tissue defects consistent with androgen insensitivity such as ambiguous external genitalia, dysgenic prostate, malformed seminal gland and cryptorchism. Males also exhibit hypospadia and infertility. Females are sterile due to failure of implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024637 VEGA Gene Model | MGI Sequence Detail 8943 C57BL/6J ±  kb
    transcript OTTMUST00000060562 VEGA | MGI Sequence Detail 2217 Not Applicable  
    polypeptide OTTMUSP00000029542 VEGA | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      36 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9812, MGI:2141664, MGI:2147626
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:10145 Kuhner MK, et al., DNA sequences of mouse H-2 and Qa genes. Immunogenetics. 1989;30(6):458-64
    • Latest
      J:258557 Tu Z, et al., Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 2016 Jan;23(1):169-81

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory