Fkbp4
Gene Detail

Symbol Name ID

Fkbp4 FK506 binding protein 4 MGI:95543

Synonyms

FKBP52, FKBP-52

Feature Type

protein coding gene

Genetic Map

Chromosome 6

63.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:128429735-128438677 bp, - strand From VEGA annotation of GRCm38   8943 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: FK506-binding protein 5
Gene Tree: Fkbp4

Human homologs

Human Homolog		FKBP4, FK506 binding protein 4, 59kDa
NCBI Gene ID		2288
neXtProt AC		NX_Q02790
Human Synonyms		FKBP51, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase
Human Chr (Location)		12p13.33; chr12:2904108-2914589 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(16)
 

Homozygous null males show reproductive tissue defects consistent with androgen insensitivity such as ambiguous external genitalia, dysgenic prostate, malformed seminal gland and cryptorchism. Males also exhibit hypospadia and infertility. Females are sterile due to failure of implantation.

 
Human Diseases Modeled Using Mouse Fkbp4 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	androgen receptor signaling pathway, chaperone-mediated protein folding, ...
Component	axonal growth cone, cytoplasm, ...
Function	ATP binding, copper-dependent protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	1

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000024637 (Evidence)
Ensembl Gene Model	ENSMUSG00000030357 (Evidence)
Entrez Gene	14228 (Evidence)
DFCI	TC1573089, TC1617208
DoTS	DT.101124371, DT.101136380, DT.101709961, DT.537018, DT.97386313
NIA Mouse Gene Index	U027899
EC	5.2.1.8
Consensus CDS Project	CCDS20573.1
International Mouse Knockout Project Status	Fkbp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024637	VEGA Gene Model | MGI Sequence Detail	8943	C57BL/6J
transcript	OTTMUST00000060562	VEGA | MGI Sequence Detail	2217	Not Applicable
polypeptide	OTTMUSP00000029542	VEGA | MGI Sequence Detail	458	Not Applicable

All sequences(58) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023114	Elongated TPR repeat-containing domain
InterPro	IPR023566	Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro	IPR001179	Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000007540	FK506-binding protein 4

References

(Earliest) J:10145 Kuhner MK, et al., DNA sequences of mouse H-2 and Qa genes. Immunogenetics. 1989;30(6):458-64
(Latest) J:184984 Hirota Y, et al., Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52. Endocrinology. 2012 May;153(5):2486-93
All references(55)

Other accession IDs

MGD-MRK-9812, MGI:2141664, MGI:2147626