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Fgg
Gene Detail
Symbol

Name
ID
Fgg
fibrinogen gamma chain
MGI:95526
Synonyms
3010002H13Rik, gamma-fibrinogen
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr3:83007724-83015049 bp, + strand
From VEGA annotation of GRCm38

  7326 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGG
Gene Tree: Fgg

Human
homologs
FGG, fibrinogen gamma chain
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2266
neXtProt AC: NX_P02679

Human Chr (Location): 4q28; chr4:154604134-154612750 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FGG

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.
 
Human Diseases Modeled in Mice Using Fgg (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fgg interacts with 54 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process adaptive immune response, blood coagulation, ...
Component blood microparticle, cell cortex, ...
Function cell adhesion molecule binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (126)    Tissues (44)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 94
RT-PCR 2
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGG ; Xenbase fgg ; ZFIN fgg    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000051802 (Evidence)
Ensembl Gene Model ENSMUSG00000033860 (Evidence)
Entrez Gene 99571 (Evidence)
DFCI TC1572343
DoTS DT.101133819, DT.496475
NIA Mouse Gene Index U003363
Consensus CDS Project CCDS38462.1
International Mouse Phenotyping Consortium Status Fgg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051802 VEGA Gene Model | MGI Sequence Detail 7326 C57BL/6J ±  kb
transcript OTTMUST00000130534 VEGA | MGI Sequence Detail 1741 Not Applicable 
polypeptide OTTMUSP00000069932 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007507 fibrinogen gamma chain
References
(Earliest) J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
(Latest) J:213857 Aleman MM, et al., Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest. 2014 Aug 1;124(8):3590-600
All references(94)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-9786, MGI:1924212, MGI:2139652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory