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Fgg Gene Detail
Summary
  • Symbol
    Fgg
  • Name
    fibrinogen gamma chain
  • Synonyms
    3010002H13Rik, gamma-fibrinogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95526
    NCBI Gene: 99571
  • Gene Overview
    MyGene.info: FGG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:83007724-83015049 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7326 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.94 cM
  • Mapping Data
    29 experiments
Homology
more
  • Human Ortholog
    FGG, fibrinogen gamma chain
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGG, fibrinogen gamma chain
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2266
    neXtProt AC: NX_P02679
    UniProt: P02679

  • Chr Location
    4q32.1; chr4:154604134-154612808 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 429
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FGG
  • Gene Tree
    Fgg
Human Diseases
more
  • Diseases
    1 with Fgg mouse models; 1 with human FGG associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051802 VEGA Gene Model | MGI Sequence Detail 7326 C57BL/6J ±  kb
    transcript OTTMUST00000130534 VEGA | MGI Sequence Detail 1741 Not Applicable  
    polypeptide OTTMUSP00000069932 VEGA | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      82 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
      IPR020837 Fibrinogen, conserved site
      IPR037581 Fibrinogen gamma chain
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9786, MGI:1924212, MGI:2139652
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
    • Latest
      J:245099 Kopec AK, et al., Thrombin promotes diet-induced obesity through fibrin-driven inflammation. J Clin Invest. 2017 Aug 01;127(8):3152-3166

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory