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Fgg
Gene Detail
 Symbol
Name
ID
Fgg
fibrinogen gamma chain
MGI:95526
Synonyms 3010002H13Rik, gamma-fibrinogen
Feature Type protein coding gene
Genetic Map
Chromosome 3
36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)
Sequence Map
Chr3:83007896-83015049 bp, + strand
From NCBI annotation of GRCm38

  7154 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fgg

Human
homologs
Human Homolog FGG, fibrinogen gamma chain
NCBI Gene ID 2266
neXtProt AC  NX_P02679
Human Chr (Location)  4q28; chr4:154604134-154612750 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.
 
Human Diseases Modeled Using Mouse Fgg (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process blood coagulation, cell-matrix adhesion, ...
Component blood microparticle, cell cortex, ...
Function cell adhesion molecule binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (126)    Tissues (44)    Images (44)
Theiler Stages: 12, 13, 20, 21, 22, 23, 24, 25
Assay TypeResults
Immunohistochemistry 30
RNA in situ 94
RT-PCR 2
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033860 (Evidence)
Entrez Gene99571 (Evidence)
DFCITC1572343
DoTSDT.101133819, DT.496475
NIA Mouse Gene IndexU003363
Consensus CDS ProjectCCDS38462.1
International Mouse Knockout Project StatusFgg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 99571 NCBI Gene Model | MGI Sequence Detail 7154 C57BL/6J ±  kb
transcript NM_133862 RefSeq | MGI Sequence Detail 1536 FVB/N 
polypeptide Q8VCM7 UniProt | EBI | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007507 fibrinogen gamma chain
Graphical View of Protein Domain Structure
References (Earliest) J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
(Latest) J:194757 Flick MJ, et al., Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood. 2013 Mar 7;121(10):1783-94
All references(97)
Other
accession IDs
MGD-MRK-9786, MGI:1924212, MGI:2139652

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory