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Fgg Gene Detail
Summary
  • Symbol
    Fgg
  • Name
    fibrinogen gamma chain
  • Synonyms
    3010002H13Rik, gamma-fibrinogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95526
    NCBI Gene: 99571
  • Gene Overview
    MyGene.info: FGG
Location & Maps
more
  • Sequence Map
    Chr3:83007724-83015049 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7326 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 36.94 cM
  • Mapping Data
    29 experiments
Homology
more
  • Human Ortholog
    FGG, fibrinogen gamma chain
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGG, fibrinogen gamma chain
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2266
    neXtProt AC: NX_P02679

  • Chr Location
    4q28; chr4:154604134-154612750 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 429
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FGG
  • Gene Tree
    Fgg
Human Diseases
more
  • Diseases
    1 with Fgg mouse models; 2 with human FGG associations

Human Disease Mouse Models
       Afibrinogenemia, Congenital   OMIM: 202400 View 1 model
       Dysfibrinogenemia, Congenital   OMIM: 616004
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    2 involving Fgg
  • Incidental Mutations
    APF
Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051802 VEGA Gene Model | MGI Sequence Detail 7326 C57BL/6J ±  kb
transcript OTTMUST00000130534 VEGA | MGI Sequence Detail 1741 Not Applicable  
polypeptide OTTMUSP00000069932 VEGA | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    82 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007507 fibrinogen gamma chain
  • InterPro Domains
    IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9786, MGI:1924212, MGI:2139652
References
more
  • Summaries
    All 91
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 5
    Phenotypes 35
  • Earliest
    J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
  • Latest
    J:213857 Aleman MM, et al., Factor XIII activity mediates red blood cell retention in venous thrombi. J Clin Invest. 2014 Aug 1;124(8):3590-600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory