Fgg
Gene Detail

Symbol Name ID

Fgg fibrinogen gamma chain MGI:95526

Synonyms

3010002H13Rik, gamma-fibrinogen

Feature Type

protein coding gene

Genetic Map

Chromosome 3

36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(29)

Sequence Map

Chr3:83007896-83015049 bp, + strand From NCBI annotation of GRCm38   7154 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fgg

Human homologs

Human Homolog		FGG, fibrinogen gamma chain
NCBI Gene ID		2266
neXtProt AC		NX_P02679
Human Chr (Location)		4q28; chr4:155525286-155533902 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Pregnant homozygous null mice exhibit retarded embryo-placental development, spontaneous abortion, and maternal death through excessive uterine bleeding. Mutants expressing a truncated polypeptide show reduced platelet aggregation, increased bleeding time, and occasional fatal neonatal bleeding.

 
Human Diseases Modeled Using Mouse Fgg (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	blood coagulation, hemostasis, ...
Component	blood microparticle, cell cortex, ...
Function	eukaryotic cell surface binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (126)    Tissues (44)    Images (44)
Theiler Stages: 12, 13, 20, 21, 22, 23, 24, 25

Assay Type	Results
Immunohistochemistry	30
RNA in situ	94
RT-PCR	2

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000033860 (Evidence)
Entrez Gene	99571 (Evidence)
DFCI	TC1572343
DoTS	DT.101133819, DT.496475
NIA Mouse Gene Index	U003363
Consensus CDS Project	CCDS38462.1
International Mouse Knockout Project Status	Fgg

Sequences

Length	Strain/Species
genomic	99571	NCBI Gene Model | MGI Sequence Detail	7154	C57BL/6J
transcript	NM_133862	RefSeq | MGI Sequence Detail	1536	FVB/N
polypeptide	Q8VCM7	UniProt | EBI | MGI Sequence Detail	436	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
InterPro	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular
InterPro	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro	IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro	IPR020837	Fibrinogen, conserved site
Protein Ontology	PR:000007507	fibrinogen gamma chain

Graphical View of Protein Domain Structure

References

(Earliest) J:9073 Blatt C, et al., Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet. 1988 Mar;14(2):133-42
(Latest) J:194757 Flick MJ, et al., Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood. 2013 Mar 7;121(10):1783-94
All references(96)

Other accession IDs

MGD-MRK-9786, MGI:1924212, MGI:2139652