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Fcgr1 Gene Detail
Summary
  • Symbol
    Fcgr1
  • Name
    Fc receptor, IgG, high affinity I
  • Synonyms
    CD64, FcgammaRI
  • Feature Type
    protein coding gene
  • IDs
    MGI:95498
    NCBI Gene: 14129
  • Gene Overview
    MyGene.info: FCGR1A
Location & Maps
more
  • Sequence Map
    Chr3:96282909-96293969 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11061 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.72 cM
  • Mapping Data
    18 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    FCGR1A, Fc fragment of IgG receptor Ia
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FCGR1A, Fc fragment of IgG receptor Ia
    Orthology source: HomoloGene
  • Synonyms
    CD64, CD64A, FCRI, IGFR1
  • Links
    NCBI Gene ID: 2209
    neXtProt AC: NX_P12314

  • Chr Location
    1q21.2-q21.3; chr1:149781275-149792518 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Fcgr1
  • Incidental Mutations
Homozygous mutation of this gene results immune response defects including a decreased inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053089 VEGA Gene Model | MGI Sequence Detail 11061 C57BL/6J ±  kb
transcript OTTMUST00000132765 VEGA | MGI Sequence Detail 2589 Not Applicable  
polypeptide OTTMUSP00000070740 VEGA | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    127 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 4
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-9732, MGI:2139673, MGI:2139933
References
more
  • Summaries
    All 130
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 71
  • Earliest
    J:8413 Hibbs ML, et al., The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980-4
  • Latest
    J:225895 Ngiow SF, et al., A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1. Cancer Res. 2015 Sep 15;75(18):3800-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory