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Fcer1a Gene Detail
Summary
  • Symbol
    Fcer1a
  • Name
    Fc receptor, IgE, high affinity I, alpha polypeptide
  • Synonyms
    Fce1a, FcERI, Fcr-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95494
    NCBI Gene: 14125
  • Gene Overview
    MyGene.info: FCER1A
Location & Maps
more
  • Sequence Map
    Chr1:173221284-173227214 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5931 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    FCER1A, Fc fragment of IgE receptor Ia
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FCER1A, Fc fragment of IgE receptor Ia
    Orthology source: HomoloGene
  • Synonyms
    FCE1A, FcERI
  • Links
    NCBI Gene ID: 2205
    neXtProt AC: NX_P12319

  • Chr Location
    1q23; chr1:159283888-159308224 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Targeted
    2
  • Transgenic
    2
  • Genomic Mutations
    2 involving Fcer1a
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal mast cell physiology and altered susceptibility to type I hypersensitivity reaction. Mice homozygous for another knock-out allele display altered development of allergic airway inflammation and airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050168 VEGA Gene Model | MGI Sequence Detail 5931 C57BL/6J ±  kb
transcript OTTMUST00000127524 VEGA | MGI Sequence Detail 998 Not Applicable  
polypeptide OTTMUSP00000068777 VEGA | MGI Sequence Detail 250 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    128 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007431 high affinity immunoglobulin epsilon receptor subunit alpha
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
Molecular
Reagents
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  • All nucleic 31
    Genomic 21
    cDNA 8
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9724, MGD-MRK-9728, MGD-MRK-9741
References
more
  • Summaries
    All 98
    Gene Ontology 7
    Phenotypes 43
  • Earliest
    J:8867 Kinet JP, et al., A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E [published erratum appears in Biochemistry 1988 Nov 15;27(23):8694]. Biochemistry. 1987 Jul 28;26(15):4605-10
  • Latest
    J:233772 Akasaki S, et al., Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. Int Immunol. 2016 Feb;28(2):65-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory