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Fbp1 Gene Detail
Summary
  • Symbol
    Fbp1
  • Name
    fructose bisphosphatase 1
  • Synonyms
    Fbp-2, Fbp3, FBPase brain isoform, FBPase liver
  • Feature Type
    protein coding gene
  • IDs
    MGI:95492
    NCBI Gene: 14121
  • Gene Overview
    MyGene.info: FBP1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:62864753-62888282 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 32.74 cM, cytoband B3-C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95492
protein coding gene Chr13:62864753-62888298 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020667
protein coding gene Chr13:62794578-62817684 (-)
A/J MGP_AJ_G0020621
protein coding gene Chr13:60538676-60561799 (-)
AKR/J MGP_AKRJ_G0020598
protein coding gene Chr13:62557489-62581021 (-)
BALB/cJ MGP_BALBcJ_G0020619
protein coding gene Chr13:60956221-60979350 (-)
C3H/HeJ MGP_C3HHeJ_G0020414
protein coding gene Chr13:62096392-62120670 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021053
protein coding gene Chr13:64860030-64883553 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018631
protein coding gene Chr13:58217632-58241282 (-)
CAST/EiJ MGP_CASTEiJ_G0019930
protein coding gene Chr13:62082081-62105469 (-)
CBA/J MGP_CBAJ_G0020374
protein coding gene Chr13:67349049-67372584 (-)
DBA/2J MGP_DBA2J_G0020499
protein coding gene Chr13:60380807-60404695 (-)
FVB/NJ MGP_FVBNJ_G0020478
protein coding gene Chr13:59492949-59516472 (-)
LP/J MGP_LPJ_G0020573
protein coding gene Chr13:63091615-63115442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020507
protein coding gene Chr13:66365640-66388854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021097
protein coding gene Chr13:61856326-61880936 (-)
PWK/PhJ MGP_PWKPhJ_G0019684
protein coding gene Chr13:59927447-59951558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019511
protein coding gene Chr13:60017255-60042696 (-)
WSB/EiJ MGP_WSBEiJ_G0019991
protein coding gene Chr13:62363582-62387103 (-)



Homology
more
  • Human Ortholog
    FBP1, fructose-bisphosphatase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FBP1, fructose-bisphosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBP
  • Links
    NCBI Gene ID: 2203
    neXtProt AC: NX_P09467
    UniProt: P09467

  • Chr Location
    9q22.32; chr9:94603133-94640257 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit reduced fasting glucose levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069805 Ensembl Gene Model | MGI Sequence Detail 23530 C57BL/6J ±  kb
    transcript ENSMUST00000092888 Ensembl | MGI Sequence Detail 1479 Not Applicable  
    polypeptide ENSMUSP00000090564 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 297
      Genomic 3
      cDNA 292
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9720, MGD-MRK-9722, MGI:1330236
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 18
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:265912 Cong J, et al., Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression. Cell Metab. 2018 Aug 7;28(2):243-255.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory