Fbp1
Gene Detail

Symbol Name ID

Fbp1 fructose bisphosphatase 1 MGI:95492

Synonyms

Fbp-2, Fbp3, FBPase brain isoform, FBPase liver

Feature Type

protein coding gene

Genetic Map

Chromosome 13

32.74 cM, cytoband B3-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:62864753-62888282 bp, - strand From VEGA annotation of GRCm38   23530 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55467  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: fructose-1,6-bisphosphatase/sedoheptulose-1,7-bisphosphatase
Gene Tree: Fbp1

Human homologs

Human Homolog		FBP1, fructose-1,6-bisphosphatase 1
NCBI Gene ID		2203
neXtProt AC		NX_P09467
Human Synonyms		FBP
Human Chr (Location)		9q22.3; chr9:97365415-97402531 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FBP1

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	carbohydrate metabolic process, cellular response to drug, ...
Component	cytoplasm, cytosol
Function	AMP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (317)    Tissues (298)    Images (18)
Theiler Stages: 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	309
RT-PCR	8

cDNA source data(291)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(296) Genomic(3) cDNA(291) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026406 (Evidence)
Ensembl Gene Model	ENSMUSG00000069805 (Evidence)
Entrez Gene	14121 (Evidence)
UniGene	423078
DFCI	TC1572437
DoTS	DT.87069805
NIA Mouse Gene Index	U275872
EC	3.1.3.11
Consensus CDS Project	CCDS26590.1
International Mouse Knockout Project Status	Fbp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026406	VEGA Gene Model | MGI Sequence Detail	23530	C57BL/6J
transcript	OTTMUST00000065306	VEGA | MGI Sequence Detail	1479	Not Applicable
polypeptide	OTTMUSP00000032529	VEGA | MGI Sequence Detail	338	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(249 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020548	Fructose-1,6-bisphosphatase, active site
InterPro	IPR000146	Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase
Protein Ontology	PR:000007365	fructose-1,6-bisphosphatase 1

References

(Earliest) J:8049 Nash HR, et al., Fructose bisphosphatase isozymes of the mouse. I. Inheritance. Biochem Genet. 1985 Aug;23(7-8):499-510
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(47)

Other accession IDs

MGD-MRK-9720, MGD-MRK-9722, MGI:1330236