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Fbp2 Gene Detail
Summary
  • Symbol
    Fbp2
  • Name
    fructose bisphosphatase 2
  • Synonyms
    Fbp-1, FBPase muscle
  • Feature Type
    protein coding gene
  • IDs
    MGI:95491
    NCBI Gene: 14120
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:62836885-62858370 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21486 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 32.74 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBP2, fructose-bisphosphatase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBP2, fructose-bisphosphatase 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8789
    neXtProt AC: NX_O00757
    UniProt: O00757

  • Chr Location
    9q22.32; chr9:94558714-94593832 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This locus controls electrophoretic variation of fructose bisphosphatase isozymes in muscle. Isozymes of kidney, liver and testis are not affected. P, SEA, SWR and Peru-Coppock have a slow migrating band; SM, C3H/He, C57BL/Go, CE and DBA/2 have a fast migrating band. Heterozygotes are intermediate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14120 NCBI Gene Model | MGI Sequence Detail 21486 C57BL/6J ±  kb
    transcript NM_007994 RefSeq | MGI Sequence Detail 1294 C57BL/6  
    polypeptide P70695 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      339 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 33
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9719, MGD-MRK-9721
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 10
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:246667 Cortez-Toledo O, et al., Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PLoS One. 2017;12(2):e0171268

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory