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Fbln2 Gene Detail
Summary
  • Symbol
    Fbln2
  • Name
    fibulin 2
  • Synonyms
    5730577E14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95488
    NCBI Gene: 14115
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:91189442-91249522 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.42 cM, cytoband D-E
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    617 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95488
 protein coding gene Chr6:91189437-91249522 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031044
 protein coding gene Chr6:92799754-92859705 (+)
A/J MGP_AJ_G0031012
 protein coding gene Chr6:89262536-89322755 (+)
AKR/J MGP_AKRJ_G0030944
 protein coding gene Chr6:91742252-91802287 (+)
BALB/cJ MGP_BALBcJ_G0031024
 protein coding gene Chr6:89202856-89264964 (+)
C3H/HeJ MGP_C3HHeJ_G0030684
 protein coding gene Chr6:92638258-92699417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031483
 protein coding gene Chr6:95216197-95279832 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028651
 protein coding gene Chr6:87242116-87302007 (+)
CAST/EiJ MGP_CASTEiJ_G0030131
 protein coding gene Chr6:91856446-91917966 (+)
CBA/J MGP_CBAJ_G0030710
 protein coding gene Chr6:98750824-98810916 (+)
DBA/2J MGP_DBA2J_G0030863
 protein coding gene Chr6:88446654-88506610 (+)
FVB/NJ MGP_FVBNJ_G0030817
 protein coding gene Chr6:87653147-87714356 (+)
LP/J MGP_LPJ_G0030943
 protein coding gene Chr6:92758707-92819035 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030851
 protein coding gene Chr6:102823852-102887081 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031510
 protein coding gene Chr6:91586217-91646256 (+)
PWK/PhJ MGP_PWKPhJ_G0029847
 protein coding gene Chr6:87395333-87455826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029676
 protein coding gene Chr6:90490129-90551259 (+)
WSB/EiJ MGP_WSBEiJ_G0030215
 protein coding gene Chr6:92045946-92107220 (+)



Homology
more
  • Human Ortholog
    FBLN2, fibulin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBLN2, fibulin 2
  • Links
    NCBI Gene ID: 2199
    neXtProt AC: NX_P98095
    UniProt: P98095

  • Chr Location
    3p25.1; chr3:13549125-13638422 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a knock-out alle are viable, fertile and grossly normal with no apparent defects in elastic fiber formation in the aorta and skin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1129
  • Tissues
    120
  • cDNA Data
    13
  • Literature Summary
    24
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14115 NCBI Gene Model | MGI Sequence Detail 60081 C57BL/6J ±  kb
transcript NM_007992 RefSeq | MGI Sequence Detail 4414 C57BL/6  
polypeptide P37889 UniProt | EBI | MGI Sequence Detail 1221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 13
    Primer pair 2
    Other 4

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-9716, MGI:1922089
References
more
  • Summaries
    All 80
    Developmental Gene Expression 24
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:16328 Pan TC, et al., Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. J Cell Biol. 1993 Dec;123(5):1269-77
  • Latest
    J:345584 Mohamedi Y, et al., Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12. Int J Mol Sci. 2024 Feb 7;25(4)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory