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Fbl Gene Detail
Summary
  • Symbol
    Fbl
  • Name
    fibrillarin
  • Synonyms
    RNU3IP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95486
    NCBI Gene: 14113
  • Gene Overview
    MyGene.info: FBL
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28169748-28179269 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.67 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95486
protein coding gene Chr7:28169710-28179269 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031932
protein coding gene Chr7:26938316-26948350 (+)
A/J MGP_AJ_G0031911
protein coding gene Chr7:26286330-26295852 (+)
AKR/J MGP_AKRJ_G0031842
protein coding gene Chr7:26960694-26970128 (+)
BALB/cJ MGP_BALBcJ_G0031917
protein coding gene Chr7:26442475-26451910 (+)
C3H/HeJ MGP_C3HHeJ_G0031639
protein coding gene Chr7:27341255-27351060 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032382
protein coding gene Chr7:27809505-27819483 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029434
protein coding gene Chr7:27385032-27394304 (+)
CAST/EiJ MGP_CASTEiJ_G0030974
protein coding gene Chr7:20633626-20643352 (+)
CBA/J MGP_CBAJ_G0031602
protein coding gene Chr7:29049868-29071017 (+)
DBA/2J MGP_DBA2J_G0031755
protein coding gene Chr7:26049770-26059603 (+)
FVB/NJ MGP_FVBNJ_G0031712
protein coding gene Chr7:26123647-26133553 (+)
LP/J MGP_LPJ_G0031836
protein coding gene Chr7:27262049-27281205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031747
protein coding gene Chr7:28563465-28574383 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032412
protein coding gene Chr7:26435450-26445311 (+)
PWK/PhJ MGP_PWKPhJ_G0030697
protein coding gene Chr7:21057512-21068903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030532
protein coding gene Chr7:17427301-17437745 (+)
WSB/EiJ MGP_WSBEiJ_G0031081
protein coding gene Chr7:26771011-26781833 (+)



Homology
more
  • Human Ortholog
    FBL, fibrillarin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FBL, fibrillarin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIB, FLRN, Nop1, RNU3IP1
  • Links
    NCBI Gene ID: 2091
    neXtProt AC: NX_P22087
    UniProt: P22087

  • Chr Location
    19q13.2; chr19:39834453-39846414 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with morula arrest. Heterozygous null mice display partial embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14113 NCBI Gene Model | MGI Sequence Detail 9522 C57BL/6J ±  kb
transcript NM_007991 RefSeq | MGI Sequence Detail 1159 Not Specified  
polypeptide P35550 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9714, MGI:2146948
References
more
  • Summaries
    All 58
    Developmental Gene Expression 16
    Gene Ontology 19
    Phenotypes 6
  • Earliest
    J:20648 Aris JP, et al., cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):931-5
  • Latest
    J:264747 Shannon ML, et al., Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors. Am J Pathol. 2018 Jun;188(6):1334-1344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory