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Fbl
Gene Detail
Symbol

Name
ID
Fbl
fibrillarin
MGI:95486
Synonyms
RNU3IP1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.67 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:28169748-28179269 bp, + strand
From NCBI annotation of GRCm38

  9522 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBL
Protein SuperFamily: fibrillarin
Gene Tree: Fbl

Human
homologs
FBL, fibrillarin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2091
neXtProt AC: NX_P22087

Human Synonyms: FIB, FLRN, RNU3IP1

Human Chr (Location): 19q13.1; chr19:39834453-39846414 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(12)
Incidental mutations (data from CvDC )
 
Homozygous null mice display embryonic lethality with morula arrest. Heterozygous null mice display partial embryonic lethality.
 
Interactions
Fbl interacts with 17 markers (Mir144, Mir329, Mir344g, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (25)    Tissues (14)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 20
cDNA source data(11)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase fbl ; ZFIN fbl    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000046865 (Evidence)
Entrez Gene 14113 (Evidence)
DFCI TC1574798
DoTS DT.102550340, DT.535245, DT.94354150, DT.94393004, DT.97348697
NIA Mouse Gene Index U017435, U055654
EC 2.1.1.-
Consensus CDS Project CCDS21036.1
International Mouse Phenotyping Consortium Status Fbl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14113 NCBI Gene Model | MGI Sequence Detail 9522 C57BL/6J ±  kb
transcript NM_007991 RefSeq | MGI Sequence Detail 1159 Not Specified 
polypeptide P35550 UniProt | EBI | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000692 Fibrillarin
InterPro IPR020813 Fibrillarin, conserved site
Protein Ontology PR:000007356 rRNA 2'-O-methyltransferase fibrillarin
Graphical View of Protein Domain Structure
References
(Earliest) J:20648 Aris JP, et al., cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):931-5
(Latest) J:197929 Sugihara Y, et al., Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Gene. 2013 May 25;521(1):91-9
All references(57)
Other
accession IDs
MGD-MRK-9714, MGI:2146948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory