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Fbl Gene Detail
Summary
  • Symbol
    Fbl
  • Name
    fibrillarin
  • Synonyms
    RNU3IP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95486
    NCBI Gene: 14113
Location & Maps
more
  • Sequence Map
    Chr7:28169748-28179269 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9522 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FBL, fibrillarin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FBL, fibrillarin
    Orthology source: HomoloGene
  • Synonyms
    FIB, FLRN, RNU3IP1
  • Links
    NCBI Gene ID: 2091
    neXtProt AC: NX_P22087

  • Chr Location
    19q13.1; chr19:39834453-39846414 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    12
  • Incidental Mutations
Homozygous null mice display embryonic lethality with morula arrest. Heterozygous null mice display partial embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14113 NCBI Gene Model | MGI Sequence Detail 9522 C57BL/6J ±  kb
transcript NM_007991 RefSeq | MGI Sequence Detail 1159 Not Specified  
polypeptide P35550 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007356 rRNA 2'-O-methyltransferase fibrillarin
  • EC
  • InterPro Domains
    IPR000692 Fibrillarin
    IPR020813 Fibrillarin, conserved site
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-9714, MGI:2146948
References
more
  • Summaries
    All 55
    Developmental Gene Expression 14
    Gene Ontology 19
    Phenotypes 6
  • Earliest
    J:20648 Aris JP, et al., cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):931-5
  • Latest
    J:197929 Sugihara Y, et al., Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Gene. 2013 May 25;521(1):91-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory