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Fbl
Gene Detail
Symbol

Name
ID
Fbl
fibrillarin
MGI:95486
Synonyms
RNU3IP1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.67 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:28169748-28179269 bp, + strand
From NCBI annotation of GRCm38

  9522 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fibrillarin
Gene Tree: Fbl

Human
homologs
Human Homolog FBL, fibrillarin
NCBI Gene ID 2091
neXtProt AC  NX_P22087
Human Synonyms  FIB, FLRN, RNU3IP1
Human Chr (Location)  19q13.1; chr19:39834453-39846414 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(12)
 
Homozygous null mice display embryonic lethality with morula arrest. Heterozygous null mice display partial embryonic lethality.
 
Interactions
Fbl interacts with 17 markers (Mir144, Mir329, Mir344g, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (25)    Tissues (14)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 20
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000046865 (Evidence)
Entrez Gene14113 (Evidence)
DFCITC1574798
DoTSDT.102550340, DT.535245, DT.94354150, DT.94393004, DT.97348697
NIA Mouse Gene IndexU017435, U055654
EC2.1.1.-
Consensus CDS ProjectCCDS21036.1
International Mouse Knockout Project StatusFbl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14113 NCBI Gene Model | MGI Sequence Detail 9522 C57BL/6J ±  kb
transcript NM_007991 RefSeq | MGI Sequence Detail 1159 Not Specified 
polypeptide P35550 UniProt | EBI | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000692 Fibrillarin
InterPro IPR020813 Fibrillarin, conserved site
Protein Ontology PR:000007356 rRNA 2'-O-methyltransferase fibrillarin
Graphical View of Protein Domain Structure
References
(Earliest) J:20648 Aris JP, et al., cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):931-5
(Latest) J:197929 Sugihara Y, et al., Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Gene. 2013 May 25;521(1):91-9
All references(57)
Other
accession IDs
MGD-MRK-9714, MGI:2146948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory