About   Help   FAQ
Fasn Gene Detail
Summary
  • Symbol
    Fasn
  • Name
    fatty acid synthase
  • Synonyms
    A630082H08Rik, FAS
  • Feature Type
    protein coding gene
  • IDs
    MGI:95485
    NCBI Gene: 14104
  • Gene Overview
    MyGene.info: FASN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120805958-120824547 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.56 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95485
protein coding gene Chr11:120805846-120824547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019531
protein coding gene Chr11:125312964-125331665 (-)
A/J MGP_AJ_G0019498
protein coding gene Chr11:119717508-119736209 (-)
AKR/J MGP_AKRJ_G0019468
protein coding gene Chr11:123339171-123357872 (-)
BALB/cJ MGP_BALBcJ_G0019473
protein coding gene Chr11:120077569-120096270 (-)
C3H/HeJ MGP_C3HHeJ_G0019279
protein coding gene Chr11:123666294-123684995 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019922
protein coding gene Chr11:129112906-129131607 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017547
protein coding gene Chr11:116706358-116725233 (-)
CAST/EiJ MGP_CASTEiJ_G0018833
protein coding gene Chr11:125168590-125187274 (-)
CBA/J MGP_CBAJ_G0019250
protein coding gene Chr11:134137581-134156282 (-)
DBA/2J MGP_DBA2J_G0019363
protein coding gene Chr11:119090747-119109448 (-)
FVB/NJ MGP_FVBNJ_G0019354
protein coding gene Chr11:118804815-118823516 (-)
LP/J MGP_LPJ_G0019434
protein coding gene Chr11:125602481-125621182 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019387
protein coding gene Chr11:132969818-132988519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019961
protein coding gene Chr11:124009362-124028063 (-)
PWK/PhJ MGP_PWKPhJ_G0018599
protein coding gene Chr11:120528183-120547226 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018391
protein coding gene Chr11:123770732-123789453 (-)
WSB/EiJ MGP_WSBEiJ_G0018886
protein coding gene Chr11:123999167-124017867 (-)



Homology
more
  • Human Ortholog
    FASN, fatty acid synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FASN, fatty acid synthase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FAS, OA-519, SDR27X1
  • Links
    NCBI Gene ID: 2194
    neXtProt AC: NX_P49327
    UniProt: P49327

  • Chr Location
    17q25.3; chr17:82078338-82098303 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14104 NCBI Gene Model | MGI Sequence Detail 18590 C57BL/6J ±  kb
    transcript NM_007988 RefSeq | MGI Sequence Detail 9938 C57BL/6  
    polypeptide P19096 UniProt | EBI | MGI Sequence Detail 2504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 27
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9712, MGI:2443287
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 27
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:9167 Paulauskis JD, et al., Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3-L1 cells. J Biol Chem. 1988 May 25;263(15):7049-54
    • Latest
      J:247887 Young KE, et al., Fatty acid synthase regulates the pathogenicity of Th17 cells. J Leukoc Biol. 2017 Nov;102(5):1229-1235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory