About   Help   FAQ
Fasn Gene Detail
Summary
  • Symbol
    Fasn
  • Name
    fatty acid synthase
  • Synonyms
    A630082H08Rik, FAS
  • Feature Type
    protein coding gene
  • IDs
    MGI:95485
    NCBI Gene: 14104
  • Gene Overview
    MyGene.info: FASN
Location & Maps
more
  • Sequence Map
    Chr11:120805846-120824547 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18702 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.56 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    FASN, fatty acid synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FASN, fatty acid synthase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FAS, OA-519, SDR27X1
  • Links
    NCBI Gene ID: 2194
    neXtProt AC: NX_P49327

  • Chr Location
    17q25; chr17:82078338-82098289 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004143 VEGA Gene Model | MGI Sequence Detail 18702 C57BL/6J ±  kb
transcript OTTMUST00000009377 VEGA | MGI Sequence Detail 10050 Not Applicable  
polypeptide OTTMUSP00000004562 VEGA | MGI Sequence Detail 2504 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    33 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 26
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-9712, MGI:2443287
References
more
  • Summaries
    All 92
    Developmental Gene Expression 27
    Gene Ontology 10
    Phenotypes 18
  • Earliest
    J:9167 Paulauskis JD, et al., Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3-L1 cells. J Biol Chem. 1988 May 25;263(15):7049-54
  • Latest
    J:231339 Vergnes L, et al., SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016 Mar;57(3):410-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory